DOI: 10.1242/dev.110.1.141. The closely related <i>Drosophila sry β</i> and <i>sry δ</i> zinc finger proteins show differential embryonic expression and distinct patterns of binding sites on polytene chromosomes

10.1242/dev.110.1.141

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract Serendipity (sry) beta (β) and delta (δ) are two finger protein genes resulting from a duplication event. Comparison of their respective protein products shows interspersed blocks of conserved and divergent amino-acid sequences. The most extensively conserved region corresponds to the predicted DNA-binding domain which includes 6 contiguous fingers; no significant sequence conservation is found upstream and downstream of the protein-coding region. We have analysed the evolutionary divergence of the sry β and δ proteins on two separate levels, their embryonic pattern of expression and their DNA-binding properties in vitro and in vivo. By using specific antibodies and transformant lines containing β -galactosidase fusion genes, we show that the sry β and sry δ proteins are maternally inherited and present in embryonic nuclei at the onset of zygotic transcription, suggesting that they are transcription factors involved in this process. Zygotic synthesis of the sry β protein starts during nuclear division cycles 12– 13, prior to cellularisation of the blastoderm, while the zygotic sry δ protein is not detectable before germ band extension (stage 10 embryos). Contrary to sry δ, the zygotic sry β protein constitutes only a minor fraction of the total embryonic protein. The sry δ and δ proteins made in E. coli bind to DNA, with partly overlapping specificities. Their in vivo patterns of binding to DNA, visualised by immunostaining polytene chromosomes, differ both in the number and position of their binding sites. Thus changes in expression pattern and DNA-binding specificity have contributed to the evolution of the sry β and δ genes.

Bibliography

Payre, F., Noselli, S., LefrÃ¨re, V., & Vincent, A. (1990). The closely related Drosophila sry Î² and sry Î´ zinc finger proteins show differential embryonic expression and distinct patterns of binding sites on polytene chromosomes. Development, 110(1), 141â149.

Authors 4

François Payre (first)
Stéphane Noselli (additional)
Valérie Lefrère (additional)
Alain Vincent (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:52 p.m.)
Deposited	8 months, 2 weeks ago (Dec. 17, 2024, 5:18 p.m.)
Indexed	8 months, 2 weeks ago (Dec. 18, 2024, 12:38 a.m.)
Issued	35 years ago (Sept. 1, 1990)
Published	35 years ago (Sept. 1, 1990)
Published Online	35 years ago (Sept. 1, 1990)
Published Print	35 years ago (Sept. 1, 1990)

Funders 0

None

BibTeX

@article{Payre_1990, title={The closely related Drosophila sry β and sry δ zinc finger proteins show differential embryonic expression and distinct patterns of binding sites on polytene chromosomes}, volume={110}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.110.1.141}, DOI={10.1242/dev.110.1.141}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Payre, François and Noselli, Stéphane and Lefrère, Valérie and Vincent, Alain}, year={1990}, month=sep, pages={141–149} }

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  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>Serendipity (sry) beta (\u03b2) and delta (\u03b4) are two finger protein genes resulting from a duplication event. Comparison of their respective protein products shows interspersed blocks of conserved and divergent amino-acid sequences. The most extensively conserved region corresponds to the predicted DNA-binding domain which includes 6 contiguous fingers; no significant sequence conservation is found upstream and downstream of the protein-coding region. We have analysed the evolutionary divergence of the sry \u03b2 and \u03b4 proteins on two separate levels, their embryonic pattern of expression and their DNA-binding properties in vitro and in vivo. By using specific antibodies and transformant lines containing \u03b2 -galactosidase fusion genes, we show that the sry \u03b2 and sry \u03b4 proteins are maternally inherited and present in embryonic nuclei at the onset of zygotic transcription, suggesting that they are transcription factors involved in this process. Zygotic synthesis of the sry \u03b2 protein starts during nuclear division cycles 12\u2013 13, prior to cellularisation of the blastoderm, while the zygotic sry \u03b4 protein is not detectable before germ band extension (stage 10 embryos). Contrary to sry \u03b4, the zygotic sry \u03b2 protein constitutes only a minor fraction of the total embryonic protein. The sry \u03b4 and \u03b4 proteins made in E. coli bind to DNA, with partly overlapping specificities. Their in vivo patterns of binding to DNA, visualised by immunostaining polytene chromosomes, differ both in the number and position of their binding sites. Thus changes in expression pattern and DNA-binding specificity have contributed to the evolution of the sry \u03b2 and \u03b4 genes.</jats:p>",
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