DOI: 10.1242/dev.109.4.833. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for <i>Bone Morphogenetic Protein-2A (BMP-2A)</i>

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)

10.1242/dev.109.4.833

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract Bone morphogenetic protein-2A (BMP-2A) is a member of the transforming growth factor β (TGF β) gene family that has been implicated in cartilage and bone formation. Here we use in situ hybridization to show that BMP-2A RNA is expressed in a variety of embryonic epithelial and mesenchymal tissues outside of the developing skeletal system, including cell populations known to play important roles in morphogenesis. Thus, high levels of transcripts are found in developing limb buds (ventral ectoderm and apical ectodermal ridge), heart (myocardium of the atrioventricular canal), whisker follicles (ectodermal placodes, hair matrix and precortex cells), tooth buds (epithelial buds, dental papilla and odontoblasts), and craniofacial mesenchyme, as well as a number of other sites. The expression patterns of BMP-2A are different from those of TGF β-1, -2 and -3, and this is illustrated in detail in the developing whisker follicles. These results suggest that BMP-2A plays multiple roles in morphogenesis and pattern formation in the vertebrate embryo.

Bibliography

Lyons, K. M., Pelton, R. W., & Hogan, B. L. M. (1990). Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A). Development, 109(4), 833â844.

Authors 3

Karen M. Lyons (first)
Ron W. Pelton (additional)
Brigid L. M. Hogan (additional)

References 48 Referenced 510

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Dates

Type	When
Created	4 years, 4 months ago (April 24, 2021, 5:17 a.m.)
Deposited	2 years, 3 months ago (May 3, 2023, 7:08 a.m.)
Indexed	3 weeks ago (Aug. 6, 2025, 8:43 a.m.)
Issued	35 years ago (Aug. 1, 1990)
Published	35 years ago (Aug. 1, 1990)
Published Online	35 years ago (Aug. 1, 1990)
Published Print	35 years ago (Aug. 1, 1990)

Funders 0

None

BibTeX

@article{Lyons_1990, title={Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)}, volume={109}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.109.4.833}, DOI={10.1242/dev.109.4.833}, number={4}, journal={Development}, publisher={The Company of Biologists}, author={Lyons, Karen M. and Pelton, Ron W. and Hogan, Brigid L. M.}, year={1990}, month=aug, pages={833–844} }

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