DOI: 10.1242/dev.109.1.29. Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis*

Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis*

10.1242/dev.109.1.29

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The possible in vivo role of TGF-beta 1 in regulating various proteins of the extracellular matrix, including fibronectin, collagen I and III, and glycosaminoglycans, was examined by immunohistochemical methods during critical stages of lung morphogenesis in the 11-to 18-day-old mouse embryo. Sections of Bouin-fixed, paraf-fin-embedded whole embryos were exposed to polyclonal antibodies specific to synthetic peptides present in the precursor part of TGF-beta 1 (pro-TGF-beta 1), in the processed TGF-beta 1 (antibody CC), collagen J and HI, fibronectin, followed by the PAP or ABC technique to visualize the location of the antibody. GAG were stained with Alcian Blue 8GX. Our results indicate colocalization of TGF-beta 1 expression and that of matrix proteins in the developing lung when branching morphogenesis (cleft formation) and tissue stabilization occur. The presence of TGF-beta 1 at the epithelialmesenchymal interfaces of stalks and clefts at a time when matrix proteins can first be visualized in these areas, suggests a direct participation of the growth factor in the development of the basic architecture of the lung.

Bibliography

Heine, U. I., Munoz, E. F., Flanders, K. C., Roberts, A. B., & Sporn, M. B. (1990). Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis*. Development, 109(1), 29â36.

Authors 5

Ursula I. Heine (first)
Eliana F. Munoz (additional)
Kathleen C. Flanders (additional)
Anita B. Roberts (additional)
Michael B. Sporn (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 8:50 p.m.)
Deposited	1 year, 8 months ago (Dec. 14, 2023, 8:47 p.m.)
Indexed	1 day, 22 hours ago (Sept. 3, 2025, 6:47 a.m.)
Issued	35 years, 4 months ago (May 1, 1990)
Published	35 years, 4 months ago (May 1, 1990)
Published Online	35 years, 4 months ago (May 1, 1990)
Published Print	35 years, 4 months ago (May 1, 1990)

Funders 0

None

BibTeX

@article{Heine_1990, title={Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis*}, volume={109}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.109.1.29}, DOI={10.1242/dev.109.1.29}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Heine, Ursula I. and Munoz, Eliana F. and Flanders, Kathleen C. and Roberts, Anita B. and Sporn, Michael B.}, year={1990}, month=may, pages={29–36} }

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