LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
10.1242/dev.01117
Crossref journal-article
The Company of Biologists
Development (237)
Abstract

Wnt signaling through the canonical β-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/β-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular β-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.

Bibliography

He, X., Semenov, M., Tamai, K., & Zeng, X. (2004). LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way. Development, 131(8), 1663–1677.

Authors 4
  1. Xi He (first)
  2. Mikhail Semenov (additional)
  3. Keiko Tamai (additional)
  4. Xin Zeng (additional)
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Dates
Type When
Created 21 years, 4 months ago (March 30, 2004, 5:33 p.m.)
Deposited 8 months, 1 week ago (Dec. 15, 2024, 1:26 p.m.)
Indexed 3 days, 11 hours ago (Aug. 26, 2025, 2:24 a.m.)
Issued 21 years, 4 months ago (April 15, 2004)
Published 21 years, 4 months ago (April 15, 2004)
Published Print 21 years, 4 months ago (April 15, 2004)
Funders 0

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@article{He_2004, title={LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way}, volume={131}, ISSN={0950-1991}, url={http://dx.doi.org/10.1242/dev.01117}, DOI={10.1242/dev.01117}, number={8}, journal={Development}, publisher={The Company of Biologists}, author={He, Xi and Semenov, Mikhail and Tamai, Keiko and Zeng, Xin}, year={2004}, month=apr, pages={1663–1677} }