DOI: 10.1210/jc.2004-1380. Lack of Effect of Calcium Intake on the 25-Hydroxyvitamin D Response to Oral Vitamin D3

Lack of Effect of Calcium Intake on the 25-Hydroxyvitamin D Response to Oral Vitamin D3

10.1210/jc.2004-1380

Crossref journal-article

The Endocrine Society

The Journal of Clinical Endocrinology & Metabolism (80)

Abstract

This study was conducted to examine the effect of calcium intake on the rise in serum 25-hydroxyvitamin D [25(OH)D] levels in response to supplemental vitamin D3. Fifty-two healthy older men and women were randomly assigned to take calcium (500 mg twice daily with meals) or placebo tablets for 90 d between October 1 and the end of March. All participants were placed on 800 IU/d (20 μg/d) vitamin D3. Serum 25(OH)D measurements were made at baseline and on d 30, 60, and 90. The mean baseline 25(OH)D values were 19.2 ± 6.4 ng/ml (47.9 ± 15.9 nmol/liter) in the calcium group and 19.6 ± 6.7 ng/ml (49.1 ± 16.7 nmol/liter) in the control group (P = 0.808). The difference in pattern of change in 25(OH)D was not statistically significant (group by time interaction, P = 0.651); the calcium group increased 6.5 ± 5.9 ng/ml (16.2 ± 14.8 nmol/liter; P &lt; 0.001), and the control group increased 6.6 ± 7.0 ng/ml (16.6 ± 17.4 nmol/liter; P &lt; 0.001). The 95% confidence interval for difference in mean increase, calcium vs. control, was −3.8 ± 3.5 ng/ml (−9.6, 8.7) nmol/liter. In older men and women, the level of calcium intake, within the range of 500-1500 mg/d, does not have an important effect on the rise in serum 25(OH)D that occurs in response to 800 IU (20 μg)/d vitamin D3.

Bibliography

Goussous, R., Song, L., Dallal, G. E., & Dawson-Hughes, B. (2005). Lack of Effect of Calcium Intake on the 25-Hydroxyvitamin D Response to Oral Vitamin D3. The Journal of Clinical Endocrinology & Metabolism, 90(2), 707â711.

Authors 4

Rula Goussous (first)
Lingyi Song (additional)
Gerard E. Dallal (additional)
Bess Dawson-Hughes (additional)

References 22 Referenced 25

10.1002/jbmr.5650020307 / J Bone Miner Res / Evidence that calcium modulates circulating 25-hydroxyvitamin D in man. by Bell (1987)
10.1016/S0006-291X(87)80071-2 / Biochem Biophys Res Commun / On the regulatory importance of 1,25-dihydroxyvitamin D3 and dietary calcium on serum levels of 25-hydroxyvitamin D3 in rats. by Berlin (1987)
10.1111/j.1365-2362.1988.tb01165.x / Eur J Clin Invest / Effect of calcium intake on serum levels of 25-hydroxyvitamin D3. by Berlin (1988)
10.1056/NEJM198510313131804 / N Engl J Med / Substrate-product relation of 1-hydroxylase activity in primary hyperparathyroidism. by LoCascio (1985)
10.1016/S0140-6736(79)92624-2 / Lancet / Modulation of plasma 1,25-dihydroxyvitamin D in man by stimulation and suppression tests. by Eisman (1979)
10.1007/BF02411300 / Calcif Tissue Int / Effect of the administration of 1,25-dihydroxyvitamin D3 on serum levels of 25-hydroxyvitamin D in postmenopausal osteoporosis. by Lore (1982)
10.1172/JCI111568 / J Clin Invest / Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man. by Bell (1984)
10.1172/JCI112619 / J Clin Invest / Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. by Halloran (1986)
10.1038/325062a0 / Nature / A new mechanism for induced vitamin D deficiency in calcium deprivation. by Clements (1987)
10.1042/cs0730659 / Clin Sci / Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism. by Clements (1987)
10.1016/0895-4356(90)90099-B / J Clin Epidemiol / Validation of a self-administered diet history questionnaire using multiple diet records. by Block (1990)
10.1093/ajcn/73.2.288 / Am J Clin Nutr / Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. by Vieth (2001)
10.1210/jcem-67-2-373 / J Clin Endocrinol Metab / Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. by Webb (1988)
10.1093/ajcn/49.2.372 / Am J Clin Nutr / Meal effects on calcium absorption. by Heaney (1989)
10.1056/NEJM198507113130202 / N Engl J Med / Calcium absorption and achlorhydria. by Recker (1985)
10.1002/jbmr.5650030303 / J Bone Miner Res / Dose dependency of calcium absorption: a comparison of calcium carbonate and calcium citrate. by Harvey (1988)
10.1093/ajcn/77.1.204 / Am J Clin Nutr / Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. by Heaney (2003)
10.1056/NEJM199709043371003 / N Engl J Med / Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. by Dawson-Hughes Harris (1997)
10.1007/s001980050058 / Osteoporos Int / Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. by Barger-Lux MJ Heaney (1998)
10.1080/07315724.2002.10719235 / J Am Coll Nutr / Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3. by Harris (2002)
{'key': '2020071616565472000_R21', 'first-page': '263', 'article-title': 'Vitamin D round table', 'author': 'Dawson-Hughes', 'year': '2004', 'journal-title': 'In: Burckhardt P, Dawson-Hughes B, Heaney RP, eds. Nutritional aspects of osteoporosis, 2nd ed. San Diego: Elsevier;'} / In: Burckhardt P, Dawson-Hughes B, Heaney RP, eds. Nutritional aspects of osteoporosis, 2nd ed. San Diego: Elsevier; / Vitamin D round table by Dawson-Hughes (2004)
{'key': '2020071616565472000_R22', 'year': '1997'} (1997)

Dates

Type	When
Created	20 years, 6 months ago (Feb. 7, 2005, 8:17 p.m.)
Deposited	5 years, 1 month ago (July 16, 2020, 11:28 p.m.)
Indexed	1 year ago (July 29, 2024, 10:32 a.m.)
Issued	20 years, 6 months ago (Feb. 1, 2005)
Published	20 years, 6 months ago (Feb. 1, 2005)
Published Print	20 years, 6 months ago (Feb. 1, 2005)

Funders 0

None

BibTeX

@article{Goussous_2005, title={Lack of Effect of Calcium Intake on the 25-Hydroxyvitamin D Response to Oral Vitamin D3}, volume={90}, ISSN={1945-7197}, url={http://dx.doi.org/10.1210/jc.2004-1380}, DOI={10.1210/jc.2004-1380}, number={2}, journal={The Journal of Clinical Endocrinology & Metabolism}, publisher={The Endocrine Society}, author={Goussous, Rula and Song, Lingyi and Dallal, Gerard E. and Dawson-Hughes, Bess}, year={2005}, month=feb, pages={707–711} }

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  "abstract": "<jats:p>This study was conducted to examine the effect of calcium intake on the rise in serum 25-hydroxyvitamin D [25(OH)D] levels in response to supplemental vitamin D3. Fifty-two healthy older men and women were randomly assigned to take calcium (500 mg twice daily with meals) or placebo tablets for 90 d between October 1 and the end of March. All participants were placed on 800 IU/d (20 \u03bcg/d) vitamin D3. Serum 25(OH)D measurements were made at baseline and on d 30, 60, and 90. The mean baseline 25(OH)D values were 19.2 \u00b1 6.4 ng/ml (47.9 \u00b1 15.9 nmol/liter) in the calcium group and 19.6 \u00b1 6.7 ng/ml (49.1 \u00b1 16.7 nmol/liter) in the control group (P = 0.808). The difference in pattern of change in 25(OH)D was not statistically significant (group by time interaction, P = 0.651); the calcium group increased 6.5 \u00b1 5.9 ng/ml (16.2 \u00b1 14.8 nmol/liter; P &amp;lt; 0.001), and the control group increased 6.6 \u00b1 7.0 ng/ml (16.6 \u00b1 17.4 nmol/liter; P &amp;lt; 0.001). The 95% confidence interval for difference in mean increase, calcium vs. control, was \u22123.8 \u00b1 3.5 ng/ml (\u22129.6, 8.7) nmol/liter. In older men and women, the level of calcium intake, within the range of 500-1500 mg/d, does not have an important effect on the rise in serum 25(OH)D that occurs in response to 800 IU (20 \u03bcg)/d vitamin D3.</jats:p>",
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