DOI: 10.1210/endo.138.9.5359. The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage*

The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage*

10.1210/endo.138.9.5359

Crossref journal-article

The Endocrine Society

Endocrinology (80)

Bibliography

Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1997). The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage*. Endocrinology, 138(9), 4013â4021.

Authors 4

Robert S. Weinstein (first)
Robert L. Jilka (additional)
A. Michael Parfitt (additional)
Stavros C. Manolagas (additional)

References 44 Referenced 79

10.1056/NEJM199502023320506 / N Engl J Med / Bone marrow cytokines and bone remodeling: emerging insights into the pathophysiology of osteoporosis. by Manolagas (1995)
10.1126/science.1621100 / Science / Increased osteoclast development after estrogen loss: mediation by interleukin-6. by Jilka (1992)
10.1172/JCI117995 / J Clin Invest / Regulation of interleukin-6, osteoclastogenesis and bone mass by androgens: the role of the androgen receptor. by Bellido (1995)
10.1210/endo.133.2.8393768 / Endocrinology / Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3. by Bellido (1993)
10.1172/JCI117100 / J Clin Invest / 17β-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. by Pottratz (1994)
{'key': '2019041122072943000_R6', 'first-page': '701', 'article-title': 'Interleukin-6-type cytokines and their receptors', 'author': 'Manolagas', 'year': '1996', 'journal-title': 'In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic Press, San Diego, pp'} / In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic Press, San Diego, pp / Interleukin-6-type cytokines and their receptors by Manolagas (1996)
10.1210/endo.133.2.8393776 / Endocrinology / Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal. by Passeri (1993)
{'key': '2019041122072943000_R8', 'first-page': '3351', 'article-title': 'Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement.', 'volume': '80', 'author': 'Bismar', 'year': '1995', 'journal-title': 'J Clin Endocrinol Metab'} / J Clin Endocrinol Metab / Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement. by Bismar (1995)
10.1172/JCI115668 / J Clin Invest / 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in-vitro: a potential mechanism for the antiosteoporotic effect of estrogens. by Girasole (1992)
{'key': '2019041122072943000_R10', 'first-page': '15', 'article-title': 'Senescence-accelerated mouse (SAM): a novel murine model of aging', 'author': 'Takeda', 'year': '1994', 'journal-title': 'In: Takeda T (ed) The SAM Model of Senescence. Excerpta Medica, Elsevier, Amsterdam, pp'} / In: Takeda T (ed) The SAM Model of Senescence. Excerpta Medica, Elsevier, Amsterdam, pp / Senescence-accelerated mouse (SAM): a novel murine model of aging by Takeda (1994)
{'key': '2019041122072943000_R11', 'first-page': '276', 'article-title': 'Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis.', 'volume': '125', 'author': 'Matsushita', 'year': '1986', 'journal-title': 'Am J Pathol'} / Am J Pathol / Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis. by Matsushita (1986)
10.1172/JCI118600 / J Clin Invest / Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. by Jilka (1996)
{'key': '2019041122072943000_R13', 'first-page': 'S161', 'article-title': 'A strategy for chromosome mapping of osteoporosis-associated genes in the senescence accelerated mouse (SAM): use of high-resolution dual-energy x-ray absorptiometry', 'volume': '10', 'author': 'Reis', 'year': '1995', 'journal-title': 'J Bone Miner Res'} / J Bone Miner Res / A strategy for chromosome mapping of osteoporosis-associated genes in the senescence accelerated mouse (SAM): use of high-resolution dual-energy x-ray absorptiometry by Reis (1995)
{'key': '2019041122072943000_R14', 'first-page': 'S331', 'article-title': 'Polymorphic microsatellite markers distinguish three AKR mouse substrains that exhibit different levels of bone mineral density', 'volume': '11', 'author': 'Benes', 'year': '1996', 'journal-title': 'J Bone Miner Res'} / J Bone Miner Res / Polymorphic microsatellite markers distinguish three AKR mouse substrains that exhibit different levels of bone mineral density by Benes (1996)
10.1210/endo-128-1-259 / Endocrinology / Identification of osteoclast precursors in multilineage hemopoietic colonies. by Hattersley (1991)
10.1002/jbmr.5650070310 / J Bone Miner Res / Sequential and precise in vivo measurements of bone mineral density in rats using dual-energy x-ray absorptiometry. by Ammann (1992)
10.1007/BF02408524 / Calcif Tissue Int / Effects of castration on the bone structure of male rats: a model of osteoporosis. by Wink (1980)
10.1002/jbmr.5650040415 / J Bone Miner Res / Differential effects of gonadal function on bone histomorphometry in male and female rats. by Turner (1989)
10.1002/jbmr.5650060403 / J Bone Miner Res / Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. by Wakley (1991)
10.1007/BF02571317 / Calcif Tissue Int / Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. by Wronski (1988)
{'key': '2019041122072943000_R21', 'first-page': 'E141', 'article-title': 'Comparison of the effects of 22-oxacalcitriol and calcitriol on bone metabolism in young X-linked hypophosphatemic (HYP) mice', 'volume': '270', 'author': 'Halstead', 'year': '1996', 'journal-title': 'Am J Physiol'} / Am J Physiol / Comparison of the effects of 22-oxacalcitriol and calcitriol on bone metabolism in young X-linked hypophosphatemic (HYP) mice by Halstead (1996)
{'key': '2019041122072943000_R22', 'first-page': 'E499', 'article-title': 'Bone histomorphometry in vitamin D-deficient rats infused with calcium and phosphorus', 'volume': '246', 'author': 'Weinstein', 'year': '1984', 'journal-title': 'Am J Physiol'} / Am J Physiol / Bone histomorphometry in vitamin D-deficient rats infused with calcium and phosphorus by Weinstein (1984)
{'key': '2019041122072943000_R23', 'first-page': '455', 'article-title': 'The clinical use of bone biopsy', 'author': 'Weinstein', 'year': '1992', 'journal-title': 'In: Coe FL, Favus MJ (eds) Disorders of Bone and Mineral Metabolism. Raven Press, New York, pp'} / In: Coe FL, Favus MJ (eds) Disorders of Bone and Mineral Metabolism. Raven Press, New York, pp / The clinical use of bone biopsy by Weinstein (1992)
10.1172/JCI112499 / J Clin Invest / Multiple immunoreactive forms of osteocalcin in uremic serum. by Gundberg (1986)
10.1016/8756-3282(87)90012-3 / Bone / Decreased trabecular width and increased trabecular spacing contribute to bone loss with aging. by Weinstein (1987)
10.1056/NEJM198812293192603 / N Engl J Med / Diminished rates of bone formation in normal black adults. by Weinstein (1988)
10.1128/IAI.47.3.581-586.1985 / Infect Immun / Model of experimental chronic osteomyelitis in rats. by Rissing (1985)
10.1002/jbmr.5650020617 / J Bone Miner Res / Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. by Parfitt (1987)
10.1016/0169-6009(91)90100-E / Bone Miner / Initiation and progression of mineralization of bone nodules formed in vivo: the role of alkaline phosphatase and organic phosphate. by Bellows (1991)
{'key': '2019041122072943000_R30', 'first-page': '1', 'article-title': 'Lineage of osteogenic cells and their relationship to the stromal system. In: Peck WA (ed) Bone and Mineral Research.', 'volume': '3', 'author': 'Owen', 'year': '1985', 'journal-title': 'Elsevier, Amsterdam, vol'} / Elsevier, Amsterdam, vol / Lineage of osteogenic cells and their relationship to the stromal system. In: Peck WA (ed) Bone and Mineral Research. by Owen (1985)
10.1182/blood.V82.12.3580.3580 / Blood / Characterization of a 5-fluorouracil-enriched osteoprogenitor population of the murine bone marrow. by Falla (1993)
10.1007/BF00298994 / Calcif Tissue Int / Differentiating between orchidectomized rats and controls using measurements of trabecular bone density: a comparison among DXA, histomorphometry, and peripheral quantitative computerized tomography. by Rosen (1995)
{'key': '2019041122072943000_R33', 'first-page': '1', 'article-title': 'Stata Statistical Software Release 4 0', 'year': '1995', 'journal-title': 'Stata Corp., College Station, pp'} / Stata Corp., College Station, pp / Stata Statistical Software Release 4 0 (1995)
10.7326/0003-4819-123-6-199509150-00010 / Ann Intern Med / Severe osteoporosis in men. by Kelepouris (1995)
10.1007/BF02553294 / Calcif Tissue Int / The effect of orchidectomy on bone metabolism in aging rats. by Verhas (1986)
10.1002/jbmr.5650101117 / J Bone Miner Res / Early induction of alterations in cancellous and cortical bone histology after orchidectomy in mature rats. by Gunness (1995)
10.1210/endo.130.5.1572302 / Endocrinology / Bone and mineral metabolism in aged male rats: short and long term effects of androgen deficiency. by Vanderschueren (1992)
10.1210/jcem-65-1-53 / J Clin Endocrinol Metab / Bone histomorphometry in hypogonadal and eugonadal men with spinal osteoporosis. by Jackson (1987)
10.1007/BF02411202 / Calcif Tissue Int / Decreased mineralization in hemodialysis patients after subtotal parathyroidectomy. by Weinstein (1982)
10.1002/jbmr.5650110305 / J Bone Miner Res / Isolation and characterization of osteoblast precursor cells from human bone marrow. by Rickard (1996)
10.1002/jbmr.5650091003 / J Bone Miner Res / The bone-remodeling transient: implications for the interpretation of clinical studies of bone mass change. by Heaney (1994)
{'key': '2019041122072943000_R42', 'first-page': '45', 'article-title': 'Bone remodeling: relationship to the amount and structure of bone and the pathogenesis and prevention of fractures In: Riggs BL, Melton LJ (eds) Osteoporosis: Etiology, Diagnosis, and Management', 'author': 'Parfitt', 'year': '1988', 'journal-title': 'Raven Press, New York, pp'} / Raven Press, New York, pp / Bone remodeling: relationship to the amount and structure of bone and the pathogenesis and prevention of fractures In: Riggs BL, Melton LJ (eds) Osteoporosis: Etiology, Diagnosis, and Management by Parfitt (1988)
10.1210/endo-125-2-825 / Endocrinology / Estradiol effects on proliferation messenger ribonucleic acid for collagen and insulin-like growth factor-I and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones. by Ernst (1989)
10.1038/nm1096-1132 / Nat Med / Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-β. by Hughes (1996)

Dates

Type	When
Created	11 years, 7 months ago (Jan. 8, 2014, 11:09 a.m.)
Deposited	5 years ago (Aug. 13, 2020, 11:18 a.m.)
Indexed	11 months, 1 week ago (Sept. 16, 2024, 6:35 a.m.)
Issued	27 years, 11 months ago (Sept. 1, 1997)
Published	27 years, 11 months ago (Sept. 1, 1997)
Published Print	27 years, 11 months ago (Sept. 1, 1997)

Funders 0

None

BibTeX

@article{Weinstein_1997, title={The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage*}, volume={138}, ISSN={1945-7170}, url={http://dx.doi.org/10.1210/endo.138.9.5359}, DOI={10.1210/endo.138.9.5359}, number={9}, journal={Endocrinology}, publisher={The Endocrine Society}, author={Weinstein, Robert S. and Jilka, Robert L. and Parfitt, A. Michael and Manolagas, Stavros C.}, year={1997}, month=sep, pages={4013–4021} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        9,
        16
      ]
    ],
    "date-time": "2024-09-16T10:35:52Z",
    "timestamp": 1726482952616
  },
  "reference-count": 44,
  "publisher": "The Endocrine Society",
  "issue": "9",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1997,
        9,
        1
      ]
    ]
  },
  "DOI": "10.1210/endo.138.9.5359",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2014,
        1,
        8
      ]
    ],
    "date-time": "2014-01-08T16:09:01Z",
    "timestamp": 1389197341000
  },
  "page": "4013-4021",
  "source": "Crossref",
  "is-referenced-by-count": 79,
  "title": "The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage*",
  "prefix": "10.1210",
  "volume": "138",
  "author": [
    {
      "given": "Robert S.",
      "family": "Weinstein",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Division of Endocrinology/Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases and the McClellan Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205"
        }
      ]
    },
    {
      "given": "Robert L.",
      "family": "Jilka",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology/Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases and the McClellan Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205"
        }
      ]
    },
    {
      "given": "A. Michael",
      "family": "Parfitt",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology/Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases and the McClellan Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205"
        }
      ]
    },
    {
      "given": "Stavros C.",
      "family": "Manolagas",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Division of Endocrinology/Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases and the McClellan Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205"
        }
      ]
    }
  ],
  "member": "80",
  "reference": [
    {
      "key": "2019041122072943000_R1",
      "doi-asserted-by": "crossref",
      "first-page": "305",
      "DOI": "10.1056/NEJM199502023320506",
      "article-title": "Bone marrow cytokines and bone remodeling: emerging insights into the pathophysiology of osteoporosis.",
      "volume": "332",
      "author": "Manolagas",
      "year": "1995",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "2019041122072943000_R2",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1126/science.1621100",
      "article-title": "Increased osteoclast development after estrogen loss: mediation by interleukin-6.",
      "volume": "257",
      "author": "Jilka",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "2019041122072943000_R3",
      "doi-asserted-by": "crossref",
      "first-page": "2886",
      "DOI": "10.1172/JCI117995",
      "article-title": "Regulation of interleukin-6, osteoclastogenesis and bone mass by androgens: the role of the androgen receptor.",
      "volume": "95",
      "author": "Bellido",
      "year": "1995",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122072943000_R4",
      "doi-asserted-by": "crossref",
      "first-page": "553",
      "DOI": "10.1210/endo.133.2.8393768",
      "article-title": "Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3.",
      "volume": "133",
      "author": "Bellido",
      "year": "1993",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122072943000_R5",
      "doi-asserted-by": "crossref",
      "first-page": "944",
      "DOI": "10.1172/JCI117100",
      "article-title": "17\u03b2-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism.",
      "volume": "93",
      "author": "Pottratz",
      "year": "1994",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122072943000_R6",
      "first-page": "701",
      "article-title": "Interleukin-6-type cytokines and their receptors",
      "author": "Manolagas",
      "year": "1996",
      "journal-title": "In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic Press, San Diego, pp"
    },
    {
      "key": "2019041122072943000_R7",
      "doi-asserted-by": "crossref",
      "first-page": "822",
      "DOI": "10.1210/endo.133.2.8393776",
      "article-title": "Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal.",
      "volume": "133",
      "author": "Passeri",
      "year": "1993",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122072943000_R8",
      "first-page": "3351",
      "article-title": "Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement.",
      "volume": "80",
      "author": "Bismar",
      "year": "1995",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122072943000_R9",
      "doi-asserted-by": "crossref",
      "first-page": "883",
      "DOI": "10.1172/JCI115668",
      "article-title": "17\u03b2-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in-vitro: a potential mechanism for the antiosteoporotic effect of estrogens.",
      "volume": "89",
      "author": "Girasole",
      "year": "1992",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122072943000_R10",
      "first-page": "15",
      "article-title": "Senescence-accelerated mouse (SAM): a novel murine model of aging",
      "author": "Takeda",
      "year": "1994",
      "journal-title": "In: Takeda T (ed) The SAM Model of Senescence. Excerpta Medica, Elsevier, Amsterdam, pp"
    },
    {
      "key": "2019041122072943000_R11",
      "first-page": "276",
      "article-title": "Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis.",
      "volume": "125",
      "author": "Matsushita",
      "year": "1986",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "2019041122072943000_R12",
      "doi-asserted-by": "crossref",
      "first-page": "1732",
      "DOI": "10.1172/JCI118600",
      "article-title": "Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.",
      "volume": "97",
      "author": "Jilka",
      "year": "1996",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122072943000_R13",
      "first-page": "S161",
      "article-title": "A strategy for chromosome mapping of osteoporosis-associated genes in the senescence accelerated mouse (SAM): use of high-resolution dual-energy x-ray absorptiometry",
      "volume": "10",
      "author": "Reis",
      "year": "1995",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "2019041122072943000_R14",
      "first-page": "S331",
      "article-title": "Polymorphic microsatellite markers distinguish three AKR mouse substrains that exhibit different levels of bone mineral density",
      "volume": "11",
      "author": "Benes",
      "year": "1996",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "2019041122072943000_R15",
      "doi-asserted-by": "crossref",
      "first-page": "259",
      "DOI": "10.1210/endo-128-1-259",
      "article-title": "Identification of osteoclast precursors in multilineage hemopoietic colonies.",
      "volume": "128",
      "author": "Hattersley",
      "year": "1991",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122072943000_R16",
      "doi-asserted-by": "crossref",
      "first-page": "311",
      "DOI": "10.1002/jbmr.5650070310",
      "article-title": "Sequential and precise in vivo measurements of bone mineral density in rats using dual-energy x-ray absorptiometry.",
      "volume": "7",
      "author": "Ammann",
      "year": "1992",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "2019041122072943000_R17",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1007/BF02408524",
      "article-title": "Effects of castration on the bone structure of male rats: a model of osteoporosis.",
      "volume": "32",
      "author": "Wink",
      "year": "1980",
      "journal-title": "Calcif Tissue Int"
    },
    {
      "key": "2019041122072943000_R18",
      "doi-asserted-by": "crossref",
      "first-page": "557",
      "DOI": "10.1002/jbmr.5650040415",
      "article-title": "Differential effects of gonadal function on bone histomorphometry in male and female rats.",
      "volume": "4",
      "author": "Turner",
      "year": "1989",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "2019041122072943000_R19",
      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1002/jbmr.5650060403",
      "article-title": "Androgen treatment prevents loss of cancellous bone in the orchidectomized rat.",
      "volume": "6",
      "author": "Wakley",
      "year": "1991",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "2019041122072943000_R20",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1007/BF02571317",
      "article-title": "Temporal relationship between bone loss and increased bone turnover in ovariectomized rats.",
      "volume": "43",
      "author": "Wronski",
      "year": "1988",
      "journal-title": "Calcif Tissue Int"
    },
    {
      "key": "2019041122072943000_R21",
      "first-page": "E141",
      "article-title": "Comparison of the effects of 22-oxacalcitriol and calcitriol on bone metabolism in young X-linked hypophosphatemic (HYP) mice",
      "volume": "270",
      "author": "Halstead",
      "year": "1996",
      "journal-title": "Am J Physiol"
    },
    {
      "key": "2019041122072943000_R22",
      "first-page": "E499",
      "article-title": "Bone histomorphometry in vitamin D-deficient rats infused with calcium and phosphorus",
      "volume": "246",
      "author": "Weinstein",
      "year": "1984",
      "journal-title": "Am J Physiol"
    },
    {
      "key": "2019041122072943000_R23",
      "first-page": "455",
      "article-title": "The clinical use of bone biopsy",
      "author": "Weinstein",
      "year": "1992",
      "journal-title": "In: Coe FL, Favus MJ (eds) Disorders of Bone and Mineral Metabolism. Raven Press, New York, pp"
    },
    {
      "key": "2019041122072943000_R24",
      "doi-asserted-by": "crossref",
      "first-page": "1762",
      "DOI": "10.1172/JCI112499",
      "article-title": "Multiple immunoreactive forms of osteocalcin in uremic serum.",
      "volume": "77",
      "author": "Gundberg",
      "year": "1986",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122072943000_R25",
      "doi-asserted-by": "crossref",
      "first-page": "137",
      "DOI": "10.1016/8756-3282(87)90012-3",
      "article-title": "Decreased trabecular width and increased trabecular spacing contribute to bone loss with aging.",
      "volume": "8",
      "author": "Weinstein",
      "year": "1987",
      "journal-title": "Bone"
    },
    {
      "key": "2019041122072943000_R26",
      "doi-asserted-by": "crossref",
      "first-page": "1698",
      "DOI": "10.1056/NEJM198812293192603",
      "article-title": "Diminished rates of bone formation in normal black adults.",
      "volume": "319",
      "author": "Weinstein",
      "year": "1988",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "2019041122072943000_R27",
      "doi-asserted-by": "crossref",
      "first-page": "581",
      "DOI": "10.1128/IAI.47.3.581-586.1985",
      "article-title": "Model of experimental chronic osteomyelitis in rats.",
      "volume": "47",
      "author": "Rissing",
      "year": "1985",
      "journal-title": "Infect Immun"
    },
    {
      "key": "2019041122072943000_R28",
      "doi-asserted-by": "crossref",
      "first-page": "595",
      "DOI": "10.1002/jbmr.5650020617",
      "article-title": "Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee.",
      "volume": "2",
      "author": "Parfitt",
      "year": "1987",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "2019041122072943000_R29",
      "doi-asserted-by": "crossref",
      "first-page": "27",
      "DOI": "10.1016/0169-6009(91)90100-E",
      "article-title": "Initiation and progression of mineralization of bone nodules formed in vivo: the role of alkaline phosphatase and organic phosphate.",
      "volume": "14",
      "author": "Bellows",
      "year": "1991",
      "journal-title": "Bone Miner"
    },
    {
      "key": "2019041122072943000_R30",
      "first-page": "1",
      "article-title": "Lineage of osteogenic cells and their relationship to the stromal system. In: Peck WA (ed) Bone and Mineral Research.",
      "volume": "3",
      "author": "Owen",
      "year": "1985",
      "journal-title": "Elsevier, Amsterdam, vol"
    },
    {
      "key": "2019041122072943000_R31",
      "doi-asserted-by": "crossref",
      "first-page": "3580",
      "DOI": "10.1182/blood.V82.12.3580.3580",
      "article-title": "Characterization of a 5-fluorouracil-enriched osteoprogenitor population of the murine bone marrow.",
      "volume": "82",
      "author": "Falla",
      "year": "1993",
      "journal-title": "Blood"
    },
    {
      "key": "2019041122072943000_R32",
      "doi-asserted-by": "crossref",
      "first-page": "35",
      "DOI": "10.1007/BF00298994",
      "article-title": "Differentiating between orchidectomized rats and controls using measurements of trabecular bone density: a comparison among DXA, histomorphometry, and peripheral quantitative computerized tomography.",
      "volume": "57",
      "author": "Rosen",
      "year": "1995",
      "journal-title": "Calcif Tissue Int"
    },
    {
      "key": "2019041122072943000_R33",
      "first-page": "1",
      "article-title": "Stata Statistical Software Release 4 0",
      "year": "1995",
      "journal-title": "Stata Corp., College Station, pp"
    },
    {
      "key": "2019041122072943000_R34",
      "doi-asserted-by": "crossref",
      "first-page": "452",
      "DOI": "10.7326/0003-4819-123-6-199509150-00010",
      "article-title": "Severe osteoporosis in men.",
      "volume": "123",
      "author": "Kelepouris",
      "year": "1995",
      "journal-title": "Ann Intern Med"
    },
    {
      "key": "2019041122072943000_R35",
      "doi-asserted-by": "crossref",
      "first-page": "74",
      "DOI": "10.1007/BF02553294",
      "article-title": "The effect of orchidectomy on bone metabolism in aging rats.",
      "volume": "39",
      "author": "Verhas",
      "year": "1986",
      "journal-title": "Calcif Tissue Int"
    },
    {
      "key": "2019041122072943000_R36",
      "doi-asserted-by": "crossref",
      "first-page": "1735",
      "DOI": "10.1002/jbmr.5650101117",
      "article-title": "Early induction of alterations in cancellous and cortical bone histology after orchidectomy in mature rats.",
      "volume": "10",
      "author": "Gunness",
      "year": "1995",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "2019041122072943000_R37",
      "doi-asserted-by": "crossref",
      "first-page": "2906",
      "DOI": "10.1210/endo.130.5.1572302",
      "article-title": "Bone and mineral metabolism in aged male rats: short and long term effects of androgen deficiency.",
      "volume": "130",
      "author": "Vanderschueren",
      "year": "1992",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122072943000_R38",
      "doi-asserted-by": "crossref",
      "first-page": "53",
      "DOI": "10.1210/jcem-65-1-53",
      "article-title": "Bone histomorphometry in hypogonadal and eugonadal men with spinal osteoporosis.",
      "volume": "65",
      "author": "Jackson",
      "year": "1987",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122072943000_R39",
      "doi-asserted-by": "crossref",
      "first-page": "16",
      "DOI": "10.1007/BF02411202",
      "article-title": "Decreased mineralization in hemodialysis patients after subtotal parathyroidectomy.",
      "volume": "34",
      "author": "Weinstein",
      "year": "1982",
      "journal-title": "Calcif Tissue Int"
    },
    {
      "key": "2019041122072943000_R40",
      "doi-asserted-by": "crossref",
      "first-page": "312",
      "DOI": "10.1002/jbmr.5650110305",
      "article-title": "Isolation and characterization of osteoblast precursor cells from human bone marrow.",
      "volume": "11",
      "author": "Rickard",
      "year": "1996",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "2019041122072943000_R41",
      "doi-asserted-by": "crossref",
      "first-page": "1515",
      "DOI": "10.1002/jbmr.5650091003",
      "article-title": "The bone-remodeling transient: implications for the interpretation of clinical studies of bone mass change.",
      "volume": "9",
      "author": "Heaney",
      "year": "1994",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "2019041122072943000_R42",
      "first-page": "45",
      "article-title": "Bone remodeling: relationship to the amount and structure of bone and the pathogenesis and prevention of fractures In: Riggs BL, Melton LJ (eds) Osteoporosis: Etiology, Diagnosis, and Management",
      "author": "Parfitt",
      "year": "1988",
      "journal-title": "Raven Press, New York, pp"
    },
    {
      "key": "2019041122072943000_R43",
      "doi-asserted-by": "crossref",
      "first-page": "825",
      "DOI": "10.1210/endo-125-2-825",
      "article-title": "Estradiol effects on proliferation messenger ribonucleic acid for collagen and insulin-like growth factor-I and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones.",
      "volume": "125",
      "author": "Ernst",
      "year": "1989",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122072943000_R44",
      "doi-asserted-by": "crossref",
      "first-page": "1132",
      "DOI": "10.1038/nm1096-1132",
      "article-title": "Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-\u03b2.",
      "volume": "10",
      "author": "Hughes",
      "year": "1996",
      "journal-title": "Nat Med"
    }
  ],
  "container-title": "Endocrinology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://academic.oup.com/endo/article-pdf/138/9/4013/10362202/endo4013.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2020,
        8,
        13
      ]
    ],
    "date-time": "2020-08-13T15:18:46Z",
    "timestamp": 1597331926000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://academic.oup.com/endo/article/138/9/4013/2988632"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1997,
        9,
        1
      ]
    ]
  },
  "references-count": 44,
  "journal-issue": {
    "issue": "9",
    "published-print": {
      "date-parts": [
        [
          1997,
          9,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1210/endo.138.9.5359",
  "relation": {},
  "ISSN": [
    "0013-7227",
    "1945-7170"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1997,
        9,
        1
      ]
    ]
  }
}