DOI: 10.1210/endo.138.4.5060. Evidence for Insulin-Like Growth Factor (IGF)-Independent Transcriptional Regulation of IGF Binding Protein-3 by Growth Hormone in SKHEP-1 Human Hepatocarcinoma Cells*

Evidence for Insulin-Like Growth Factor (IGF)-Independent Transcriptional Regulation of IGF Binding Protein-3 by Growth Hormone in SKHEP-1 Human Hepatocarcinoma Cells*

10.1210/endo.138.4.5060

Crossref journal-article

The Endocrine Society

Endocrinology (80)

Bibliography

Gucev, Z. S., Oh, Y., Kelley, K. M., Labarta, J. I., Vorwerk, P., & Rosenfeld, R. G. (1997). Evidence for Insulin-Like Growth Factor (IGF)-Independent Transcriptional Regulation of IGF Binding Protein-3 by Growth Hormone in SKHEP-1 Human Hepatocarcinoma Cells*. Endocrinology, 138(4), 1464â1470.

Authors 6

Zoran S. Gucev (first)
Youngman Oh (additional)
Kevin M. Kelley (additional)
Jose I. Labarta (additional)
Peter Vorwerk (additional)
Ron G. Rosenfeld (additional)

References 48 Referenced 14

10.1111/j.1651-2227.1994.tb13315.x / Acta Paediatr [Suppl 399] / Insulin-like growth factor binding proteins and their regulation by Rosenfeld (1994)
10.1016/1357-2725(96)00005-2 / Int J Biochem / Insulin-like growth factor (IGF)-binding proteins (IGFBPs) and their regulatory dynamics. by Kelley (1996)
10.1210/jcem-69-6-1291 / J Clin Endocrinol Metab / Molecular forms of serum insulin-like growth factor (IGF)-binding proteins in man: relationships with growth hormone and IGFs and physiological significance. by Hardouin (1989)
10.1507/endocrj.40.185 / Endocr J / Comparison between insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) measurement in the diagnosis of growth hormone deficiency. by Hasegawa (1993)
10.1210/jcem-70-5-1292 / J Clin Endocrinol Metab / A specific radioimmunoassay for the growth hormone-dependent somatomedin-binding protein: its use for the diagnosis of GH deficiency. by Blum (1990)
10.1111/j.1365-2265.1992.tb01449.x / Clin Endocrinol (Oxf) / IGF binding protein 3 in patients with Laron type dwarfism: effect of exogenous rIGF-I. by Laron (1992)
{'key': '2019041122073526200_R7', 'first-page': '1393', 'article-title': 'A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency.', 'volume': '80', 'author': 'Guevara-Aguirre', 'year': '1995', 'journal-title': 'J Clin Endocrinol Metab'} / J Clin Endocrinol Metab / A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency. by Guevara-Aguirre (1995)
10.1530/acta.0.1280144 / Acta Endocrinol (Copenh) / Long-term treatment of Laron type dwarfs with insulin-like growth factor-I increases serum insulin-like factor binding protein-3 in the absence of growth hormone activity. by Kanety (1993)
10.1073/pnas.86.10.3813 / Proc Natl Acad Sci USA / Racombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats. by Zapf (1989)
10.1210/endo-125-6-2967 / Endocrinology / Insulin-like growth factor-I (IGF-I) infusion into hypophysectomized or protein-deprived rats induced specific IGF-binding proteins in serum. by Clemmons (1989)
10.1210/endo.130.1.1370151 / Endocrinology / Effects of continuous infusion of insulin-like growth factor-I and -II, alone and in combination with thyroxine or growth hormone, on the neonatal hypophysectomized rat. by Glasscock (1992)
10.1210/endo.131.6.1280211 / Endocrinology / Measurement and characterization of Insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting. by Gargosky (1992)
10.1210/jcem-63-5-1186 / J Clin Endocrinol Metab / Serum somatomedin levels in adults with chronic renal failure: the importance of measuring insulin-like growth factor I (IGF-I) and IGF-II in acid chromatographed uremic serum. by Powell (1986)
10.1016/0003-2697(86)90507-5 / Anal Biochem / Analysis of serum insulin-like growth factor binding proteins using Western blotting: use of the method for titration of the binding proteins and competitive binding studies. by Hossenlop (1986)
10.1210/jcem-72-6-1391 / J Clin Endocrinol Metab / A simple assay for proteolisis of IGFBP-3. by Lamson (1991)
10.1210/endo-128-6-2815 / Endocrinology / Differential effects of insulin-like growth factor binding proteins (IGFBPs) in a rat neuroblastoma cell line: isolation and characterization of two forms of IGFBP-4. by Ceda (1991)
{'key': '2019041122073526200_R17', 'first-page': '239', 'article-title': 'A method for isolation of intact, translationally active ribonucleic acid.', 'volume': '2', 'author': 'Cathala', 'year': '1993', 'journal-title': 'DNA'} / DNA / A method for isolation of intact, translationally active ribonucleic acid. by Cathala (1993)
10.1016/S0022-2836(83)80098-9 / J Mol Biol / Mechanism of action of DRB: effect on specific in vitro initiation of transcription. by Zandomeni (1983)
10.1677/joe.0.1270383 / J Endocrinol / Insulin-like growth factor-I (IGF-I) and IGF-binding proteins both decline in the rat during late pregnancy. by Gargosky (1990)
10.1172/JCI116272 / J Clin Invest / Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. Insulin-like growth factor dependence and biological studies. by Conover (1993)
10.1210/endo-123-4-1907 / Endocrinology / Insulin-like growth factor-binding proteins (IGFBPs) produced by human skin fibroblasts: immunological relationship to other human IGF-BPs. by Martin (1988)
10.1016/0006-291X(89)92502-3 / Biochem Biophys Res Commun / Release of insulin-like growth factor carrier proteins in osteoblasts: stimulation by estradiol and growth hormone. by Schmidt (1989)
10.1016/0014-5793(89)80556-3 / FEBS Lett / Production of carrier proteins for insulin-like growth factors (IGFs) by rat osteoblastic cells. Regulation by IGF-I and cortisol. by Schmid (1989)
10.1172/JCI113968 / J Clin Invest / Insulin-like growth factor binding proteins from cultured human fibroblasts. Characterization and hormonal regulation. by Conover (1989)
10.1210/endo-127-6-2795 / Endocrinology / Structural and biological characterization of bovine insulin-like growth factor binding protein-3. by Conover (1990)
10.1210/endo-128-2-1057 / Endocrinology / Mitogens regulate the production of insulin-like growth factor-binding protein bu Swiss 3T3 cells. by Corps (1991)
10.1210/endo-128-4-1723 / Endocrinology / The differential regulation by glucagon and growth hormone of insulin-like growth factor (IGF)-1 and IGF binding proteins in cultured rat hepatocytes. by Kachra (1991)
10.1016/S0021-9258(19)49788-3 / J Biol Chem / Identification of the forms of insulin-like growth factor binding-proteins produced by human fibroblasts and the mechanisms that regulate their secretion. by Camacho-Hubner (1992)
10.1002/jcp.1041600119 / J Cell Physiol / Complex pattern of insulin-like growth factor binding protein expression in primary rat ostoblast enriched cultures: regulation by prostaglandin E2, growth hormone, and the insulin-like growth factors. by McCarthy (1994)
10.1210/endo-127-2-807 / Endocrinology / Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein-3. by Ernst (1990)
10.1007/BF00298723 / Calcif Tissue Int / Growth hormone stimulates prolifferation and differentiation of normal human osteoblast-like cells in vitro. by Kassem (1993)
10.1677/jme.0.0130127 / J Mol Endocrinol / Growth hormone induces tyrosine phosphorylation but does not alter IGF-I gene expression in human IM9 lymphocytes. by Clayton (1994)
10.1210/endo-129-3-1201 / Endocrinology / Regulation of insulin-like growth factor binding proteins in transgenic mice with altered expression of growth hormone and IGF-I. by Cammacho-Hubner (1991)
10.1210/endo.134.5.7512499 / Endocrinology / Administration of growth hormone (GH), but not insulin-like growth-factor-I (IGF-I), by continous infusion can induce the formation of the 150-kilodalton IGF-binding protein-3 complex in GH-deficient rats. by Gargosky (1994)
10.1210/endo.130.1.1370153 / Endocrinology / Tissue distribution and regulation of insulin-like growth factor (IGF)-binding protein-3 messenger ribonucleic acid (mRNA) in the rat: comparison with IHF-I mRNA expression. by Albiston (1992)
10.1210/endo.133.2.7688291 / Endocrinology / Growth hormone (GH) stimulates insulin-like growth factor-I and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats. by Domene (1993)
10.1172/JCI112742 / J Clin Invest / Radioimmunoassay of growth hormone dependant insulin-like growth factor binding protein in human plasma. by Baxter (1986)
10.1210/jcem-70-5-1292 / J Clin Endocrinol Metab / A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. by Blum (1990)
10.1210/endo-126-1-644 / Endocrinology / Tissue, developmental and metabolic regulation of messenger ribonucleic acid encoding a rat insulin-like growth factor binding protein (rIGFBP-2). by Orlowski (1990)
10.1172/JCI114797 / J Clin Invest / Regulation of binding proteins for insulin-like growth factor (IGF) in humans. by Zapf (1990)
10.1172/JCI116212 / J Clin Invest / Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously. by Thissen (1993)
10.1210/edrv-15-3-369 / Endocr Rev / Growth hormone (GH) Insensitivity due to primary GH receptor deficiency. by Rosenfeld (1994)
{'key': '2019041122073526200_R43', 'first-page': '1683', 'article-title': 'The composition and distribution of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in the serum of growth hormone receptor deficient patients: effects of IGF-I therapy on IGFBP-3 and acid-labile subunits.', 'volume': '77', 'author': 'Gargosky', 'year': '1993', 'journal-title': 'J Clin Endocrinol Metab'} / J Clin Endocrinol Metab / The composition and distribution of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in the serum of growth hormone receptor deficient patients: effects of IGF-I therapy on IGFBP-3 and acid-labile subunits. by Gargosky (1993)
{'key': '2019041122073526200_R44', 'first-page': '273', 'article-title': 'Hormonal and metabolic effects and pharmacokinetics of recombiniant insulin-like growth factor-I in growth hormone receptor deficiency (GHRD/Laron syndrome).', 'volume': '77', 'author': 'Vaccarello', 'year': '1993', 'journal-title': 'J Clin Endocrinol Metab'} / J Clin Endocrinol Metab / Hormonal and metabolic effects and pharmacokinetics of recombiniant insulin-like growth factor-I in growth hormone receptor deficiency (GHRD/Laron syndrome). by Vaccarello (1993)
10.1002/ijc.2910590303 / Int J Cancer / Supressed expression of insulin-like growth factor binding protein-1 mRNA in the endometrium: a molecular mechanism associating endometrial cancer with its risk factors. by Rutanen (1994)
10.1530/acta.0.1280168 / Acta Endocrinol (Copenh) / The expression of insulin-like growth factors and their binding proteins in normal human lymphocytes. by Nyman (1993)
10.1038/310777a0 / Nature / Insulin-like growth factor II precursor gene organisation in relation to insulin gene family. by Dull (1984)
10.1210/mend-2-12-1176 / Mol Endocrinol / Cloning and expression of the growth hormone dependent insulin-like growth factor binding protein. by Wood (1988)

Dates

Type	When
Created	11 years, 7 months ago (Jan. 8, 2014, 11:08 a.m.)
Deposited	3 years, 5 months ago (March 21, 2022, 6:51 p.m.)
Indexed	3 months, 1 week ago (May 20, 2025, 9:32 a.m.)
Issued	28 years, 4 months ago (April 1, 1997)
Published	28 years, 4 months ago (April 1, 1997)
Published Print	28 years, 4 months ago (April 1, 1997)

Funders 0

None

BibTeX

@article{Gucev_1997, title={Evidence for Insulin-Like Growth Factor (IGF)-Independent Transcriptional Regulation of IGF Binding Protein-3 by Growth Hormone in SKHEP-1 Human Hepatocarcinoma Cells*}, volume={138}, ISSN={1945-7170}, url={http://dx.doi.org/10.1210/endo.138.4.5060}, DOI={10.1210/endo.138.4.5060}, number={4}, journal={Endocrinology}, publisher={The Endocrine Society}, author={Gucev, Zoran S. and Oh, Youngman and Kelley, Kevin M. and Labarta, Jose I. and Vorwerk, Peter and Rosenfeld, Ron G.}, year={1997}, month=apr, pages={1464–1470} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        20
      ]
    ],
    "date-time": "2025-05-20T13:32:41Z",
    "timestamp": 1747747961538
  },
  "reference-count": 48,
  "publisher": "The Endocrine Society",
  "issue": "4",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1997,
        4,
        1
      ]
    ]
  },
  "DOI": "10.1210/endo.138.4.5060",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2014,
        1,
        8
      ]
    ],
    "date-time": "2014-01-08T16:08:30Z",
    "timestamp": 1389197310000
  },
  "page": "1464-1470",
  "source": "Crossref",
  "is-referenced-by-count": 14,
  "title": "Evidence for Insulin-Like Growth Factor (IGF)-Independent Transcriptional Regulation of IGF Binding Protein-3 by Growth Hormone in SKHEP-1 Human Hepatocarcinoma Cells*",
  "prefix": "10.1210",
  "volume": "138",
  "author": [
    {
      "given": "Zoran S.",
      "family": "Gucev",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Pediatrics, Oregon Health Sciences University School of Medicine, Portland, Oregon 97201-3042"
        }
      ]
    },
    {
      "given": "Youngman",
      "family": "Oh",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pediatrics, Oregon Health Sciences University School of Medicine, Portland, Oregon 97201-3042"
        }
      ]
    },
    {
      "given": "Kevin M.",
      "family": "Kelley",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pediatrics, Oregon Health Sciences University School of Medicine, Portland, Oregon 97201-3042"
        }
      ]
    },
    {
      "given": "Jose I.",
      "family": "Labarta",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pediatrics, Oregon Health Sciences University School of Medicine, Portland, Oregon 97201-3042"
        }
      ]
    },
    {
      "given": "Peter",
      "family": "Vorwerk",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pediatrics, Oregon Health Sciences University School of Medicine, Portland, Oregon 97201-3042"
        }
      ]
    },
    {
      "given": "Ron G.",
      "family": "Rosenfeld",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Pediatrics, Oregon Health Sciences University School of Medicine, Portland, Oregon 97201-3042"
        }
      ]
    }
  ],
  "member": "80",
  "reference": [
    {
      "key": "2019041122073526200_R1",
      "doi-asserted-by": "crossref",
      "first-page": "154",
      "DOI": "10.1111/j.1651-2227.1994.tb13315.x",
      "article-title": "Insulin-like growth factor binding proteins and their regulation",
      "author": "Rosenfeld",
      "year": "1994",
      "journal-title": "Acta Paediatr [Suppl 399]"
    },
    {
      "key": "2019041122073526200_R2",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1016/1357-2725(96)00005-2",
      "article-title": "Insulin-like growth factor (IGF)-binding proteins (IGFBPs) and their regulatory dynamics.",
      "volume": "28",
      "author": "Kelley",
      "year": "1996",
      "journal-title": "Int J Biochem"
    },
    {
      "key": "2019041122073526200_R3",
      "doi-asserted-by": "crossref",
      "first-page": "1291",
      "DOI": "10.1210/jcem-69-6-1291",
      "article-title": "Molecular forms of serum insulin-like growth factor (IGF)-binding proteins in man: relationships with growth hormone and IGFs and physiological significance.",
      "volume": "69",
      "author": "Hardouin",
      "year": "1989",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122073526200_R4",
      "doi-asserted-by": "crossref",
      "first-page": "185",
      "DOI": "10.1507/endocrj.40.185",
      "article-title": "Comparison between insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) measurement in the diagnosis of growth hormone deficiency.",
      "volume": "40",
      "author": "Hasegawa",
      "year": "1993",
      "journal-title": "Endocr J"
    },
    {
      "key": "2019041122073526200_R5",
      "doi-asserted-by": "crossref",
      "first-page": "1292",
      "DOI": "10.1210/jcem-70-5-1292",
      "article-title": "A specific radioimmunoassay for the growth hormone-dependent somatomedin-binding protein: its use for the diagnosis of GH deficiency.",
      "volume": "70",
      "author": "Blum",
      "year": "1990",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122073526200_R6",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1111/j.1365-2265.1992.tb01449.x",
      "article-title": "IGF binding protein 3 in patients with Laron type dwarfism: effect of exogenous rIGF-I.",
      "volume": "36",
      "author": "Laron",
      "year": "1992",
      "journal-title": "Clin Endocrinol (Oxf)"
    },
    {
      "key": "2019041122073526200_R7",
      "first-page": "1393",
      "article-title": "A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency.",
      "volume": "80",
      "author": "Guevara-Aguirre",
      "year": "1995",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122073526200_R8",
      "doi-asserted-by": "crossref",
      "first-page": "144",
      "DOI": "10.1530/acta.0.1280144",
      "article-title": "Long-term treatment of Laron type dwarfs with insulin-like growth factor-I increases serum insulin-like factor binding protein-3 in the absence of growth hormone activity.",
      "volume": "128",
      "author": "Kanety",
      "year": "1993",
      "journal-title": "Acta Endocrinol (Copenh)"
    },
    {
      "key": "2019041122073526200_R9",
      "doi-asserted-by": "crossref",
      "first-page": "3813",
      "DOI": "10.1073/pnas.86.10.3813",
      "article-title": "Racombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats.",
      "volume": "86",
      "author": "Zapf",
      "year": "1989",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2019041122073526200_R10",
      "doi-asserted-by": "crossref",
      "first-page": "2967",
      "DOI": "10.1210/endo-125-6-2967",
      "article-title": "Insulin-like growth factor-I (IGF-I) infusion into hypophysectomized or protein-deprived rats induced specific IGF-binding proteins in serum.",
      "volume": "125",
      "author": "Clemmons",
      "year": "1989",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R11",
      "doi-asserted-by": "crossref",
      "first-page": "203",
      "DOI": "10.1210/endo.130.1.1370151",
      "article-title": "Effects of continuous infusion of insulin-like growth factor-I and -II, alone and in combination with thyroxine or growth hormone, on the neonatal hypophysectomized rat.",
      "volume": "130",
      "author": "Glasscock",
      "year": "1992",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R12",
      "doi-asserted-by": "crossref",
      "first-page": "3051",
      "DOI": "10.1210/endo.131.6.1280211",
      "article-title": "Measurement and characterization of Insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting.",
      "volume": "131",
      "author": "Gargosky",
      "year": "1992",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R13",
      "doi-asserted-by": "crossref",
      "first-page": "1186",
      "DOI": "10.1210/jcem-63-5-1186",
      "article-title": "Serum somatomedin levels in adults with chronic renal failure: the importance of measuring insulin-like growth factor I (IGF-I) and IGF-II in acid chromatographed uremic serum.",
      "volume": "63",
      "author": "Powell",
      "year": "1986",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122073526200_R14",
      "doi-asserted-by": "crossref",
      "first-page": "138",
      "DOI": "10.1016/0003-2697(86)90507-5",
      "article-title": "Analysis of serum insulin-like growth factor binding proteins using Western blotting: use of the method for titration of the binding proteins and competitive binding studies.",
      "volume": "154",
      "author": "Hossenlop",
      "year": "1986",
      "journal-title": "Anal Biochem"
    },
    {
      "key": "2019041122073526200_R15",
      "doi-asserted-by": "crossref",
      "first-page": "1391",
      "DOI": "10.1210/jcem-72-6-1391",
      "article-title": "A simple assay for proteolisis of IGFBP-3.",
      "volume": "72",
      "author": "Lamson",
      "year": "1991",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122073526200_R16",
      "doi-asserted-by": "crossref",
      "first-page": "2815",
      "DOI": "10.1210/endo-128-6-2815",
      "article-title": "Differential effects of insulin-like growth factor binding proteins (IGFBPs) in a rat neuroblastoma cell line: isolation and characterization of two forms of IGFBP-4.",
      "volume": "128",
      "author": "Ceda",
      "year": "1991",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R17",
      "first-page": "239",
      "article-title": "A method for isolation of intact, translationally active ribonucleic acid.",
      "volume": "2",
      "author": "Cathala",
      "year": "1993",
      "journal-title": "DNA"
    },
    {
      "key": "2019041122073526200_R18",
      "doi-asserted-by": "crossref",
      "first-page": "561",
      "DOI": "10.1016/S0022-2836(83)80098-9",
      "article-title": "Mechanism of action of DRB: effect on specific in vitro initiation of transcription.",
      "volume": "167",
      "author": "Zandomeni",
      "year": "1983",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "2019041122073526200_R19",
      "doi-asserted-by": "crossref",
      "first-page": "383",
      "DOI": "10.1677/joe.0.1270383",
      "article-title": "Insulin-like growth factor-I (IGF-I) and IGF-binding proteins both decline in the rat during late pregnancy.",
      "volume": "127",
      "author": "Gargosky",
      "year": "1990",
      "journal-title": "J Endocrinol"
    },
    {
      "key": "2019041122073526200_R20",
      "doi-asserted-by": "crossref",
      "first-page": "1129",
      "DOI": "10.1172/JCI116272",
      "article-title": "Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. Insulin-like growth factor dependence and biological studies.",
      "volume": "91",
      "author": "Conover",
      "year": "1993",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122073526200_R21",
      "doi-asserted-by": "crossref",
      "first-page": "1907",
      "DOI": "10.1210/endo-123-4-1907",
      "article-title": "Insulin-like growth factor-binding proteins (IGFBPs) produced by human skin fibroblasts: immunological relationship to other human IGF-BPs.",
      "volume": "123",
      "author": "Martin",
      "year": "1988",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R22",
      "doi-asserted-by": "crossref",
      "first-page": "788",
      "DOI": "10.1016/0006-291X(89)92502-3",
      "article-title": "Release of insulin-like growth factor carrier proteins in osteoblasts: stimulation by estradiol and growth hormone.",
      "volume": "160",
      "author": "Schmidt",
      "year": "1989",
      "journal-title": "Biochem Biophys Res Commun"
    },
    {
      "key": "2019041122073526200_R23",
      "doi-asserted-by": "crossref",
      "first-page": "328",
      "DOI": "10.1016/0014-5793(89)80556-3",
      "article-title": "Production of carrier proteins for insulin-like growth factors (IGFs) by rat osteoblastic cells. Regulation by IGF-I and cortisol.",
      "volume": "244",
      "author": "Schmid",
      "year": "1989",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "2019041122073526200_R24",
      "doi-asserted-by": "crossref",
      "first-page": "852",
      "DOI": "10.1172/JCI113968",
      "article-title": "Insulin-like growth factor binding proteins from cultured human fibroblasts. Characterization and hormonal regulation.",
      "volume": "83",
      "author": "Conover",
      "year": "1989",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122073526200_R25",
      "doi-asserted-by": "crossref",
      "first-page": "2795",
      "DOI": "10.1210/endo-127-6-2795",
      "article-title": "Structural and biological characterization of bovine insulin-like growth factor binding protein-3.",
      "volume": "127",
      "author": "Conover",
      "year": "1990",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R26",
      "doi-asserted-by": "crossref",
      "first-page": "1057",
      "DOI": "10.1210/endo-128-2-1057",
      "article-title": "Mitogens regulate the production of insulin-like growth factor-binding protein bu Swiss 3T3 cells.",
      "volume": "128",
      "author": "Corps",
      "year": "1991",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R27",
      "doi-asserted-by": "crossref",
      "first-page": "1723",
      "DOI": "10.1210/endo-128-4-1723",
      "article-title": "The differential regulation by glucagon and growth hormone of insulin-like growth factor (IGF)-1 and IGF binding proteins in cultured rat hepatocytes.",
      "volume": "128",
      "author": "Kachra",
      "year": "1991",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R28",
      "doi-asserted-by": "crossref",
      "first-page": "11949",
      "DOI": "10.1016/S0021-9258(19)49788-3",
      "article-title": "Identification of the forms of insulin-like growth factor binding-proteins produced by human fibroblasts and the mechanisms that regulate their secretion.",
      "volume": "267",
      "author": "Camacho-Hubner",
      "year": "1992",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2019041122073526200_R29",
      "doi-asserted-by": "crossref",
      "first-page": "163",
      "DOI": "10.1002/jcp.1041600119",
      "article-title": "Complex pattern of insulin-like growth factor binding protein expression in primary rat ostoblast enriched cultures: regulation by prostaglandin E2, growth hormone, and the insulin-like growth factors.",
      "volume": "160",
      "author": "McCarthy",
      "year": "1994",
      "journal-title": "J Cell Physiol"
    },
    {
      "key": "2019041122073526200_R30",
      "doi-asserted-by": "crossref",
      "first-page": "807",
      "DOI": "10.1210/endo-127-2-807",
      "article-title": "Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein-3.",
      "volume": "127",
      "author": "Ernst",
      "year": "1990",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R31",
      "doi-asserted-by": "crossref",
      "first-page": "222",
      "DOI": "10.1007/BF00298723",
      "article-title": "Growth hormone stimulates prolifferation and differentiation of normal human osteoblast-like cells in vitro.",
      "volume": "52",
      "author": "Kassem",
      "year": "1993",
      "journal-title": "Calcif Tissue Int"
    },
    {
      "key": "2019041122073526200_R32",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1677/jme.0.0130127",
      "article-title": "Growth hormone induces tyrosine phosphorylation but does not alter IGF-I gene expression in human IM9 lymphocytes.",
      "volume": "13",
      "author": "Clayton",
      "year": "1994",
      "journal-title": "J Mol Endocrinol"
    },
    {
      "key": "2019041122073526200_R33",
      "doi-asserted-by": "crossref",
      "first-page": "1201",
      "DOI": "10.1210/endo-129-3-1201",
      "article-title": "Regulation of insulin-like growth factor binding proteins in transgenic mice with altered expression of growth hormone and IGF-I.",
      "volume": "129",
      "author": "Cammacho-Hubner",
      "year": "1991",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R34",
      "doi-asserted-by": "crossref",
      "first-page": "2267",
      "DOI": "10.1210/endo.134.5.7512499",
      "article-title": "Administration of growth hormone (GH), but not insulin-like growth-factor-I (IGF-I), by continous infusion can induce the formation of the 150-kilodalton IGF-binding protein-3 complex in GH-deficient rats.",
      "volume": "134",
      "author": "Gargosky",
      "year": "1994",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R35",
      "doi-asserted-by": "crossref",
      "first-page": "497",
      "DOI": "10.1210/endo.130.1.1370153",
      "article-title": "Tissue distribution and regulation of insulin-like growth factor (IGF)-binding protein-3 messenger ribonucleic acid (mRNA) in the rat: comparison with IHF-I mRNA expression.",
      "volume": "130",
      "author": "Albiston",
      "year": "1992",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R36",
      "doi-asserted-by": "crossref",
      "first-page": "675",
      "DOI": "10.1210/endo.133.2.7688291",
      "article-title": "Growth hormone (GH) stimulates insulin-like growth factor-I and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats.",
      "volume": "133",
      "author": "Domene",
      "year": "1993",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R37",
      "doi-asserted-by": "crossref",
      "first-page": "1504",
      "DOI": "10.1172/JCI112742",
      "article-title": "Radioimmunoassay of growth hormone dependant insulin-like growth factor binding protein in human plasma.",
      "volume": "78",
      "author": "Baxter",
      "year": "1986",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122073526200_R38",
      "doi-asserted-by": "crossref",
      "first-page": "1292",
      "DOI": "10.1210/jcem-70-5-1292",
      "article-title": "A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency.",
      "volume": "70",
      "author": "Blum",
      "year": "1990",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122073526200_R39",
      "doi-asserted-by": "crossref",
      "first-page": "644",
      "DOI": "10.1210/endo-126-1-644",
      "article-title": "Tissue, developmental and metabolic regulation of messenger ribonucleic acid encoding a rat insulin-like growth factor binding protein (rIGFBP-2).",
      "volume": "126",
      "author": "Orlowski",
      "year": "1990",
      "journal-title": "Endocrinology"
    },
    {
      "key": "2019041122073526200_R40",
      "doi-asserted-by": "crossref",
      "first-page": "952",
      "DOI": "10.1172/JCI114797",
      "article-title": "Regulation of binding proteins for insulin-like growth factor (IGF) in humans.",
      "volume": "86",
      "author": "Zapf",
      "year": "1990",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122073526200_R41",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1172/JCI116212",
      "article-title": "Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously.",
      "volume": "91",
      "author": "Thissen",
      "year": "1993",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "2019041122073526200_R42",
      "doi-asserted-by": "crossref",
      "first-page": "369",
      "DOI": "10.1210/edrv-15-3-369",
      "article-title": "Growth hormone (GH) Insensitivity due to primary GH receptor deficiency.",
      "volume": "15",
      "author": "Rosenfeld",
      "year": "1994",
      "journal-title": "Endocr Rev"
    },
    {
      "key": "2019041122073526200_R43",
      "first-page": "1683",
      "article-title": "The composition and distribution of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in the serum of growth hormone receptor deficient patients: effects of IGF-I therapy on IGFBP-3 and acid-labile subunits.",
      "volume": "77",
      "author": "Gargosky",
      "year": "1993",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122073526200_R44",
      "first-page": "273",
      "article-title": "Hormonal and metabolic effects and pharmacokinetics of recombiniant insulin-like growth factor-I in growth hormone receptor deficiency (GHRD/Laron syndrome).",
      "volume": "77",
      "author": "Vaccarello",
      "year": "1993",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "2019041122073526200_R45",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1002/ijc.2910590303",
      "article-title": "Supressed expression of insulin-like growth factor binding protein-1 mRNA in the endometrium: a molecular mechanism associating endometrial cancer with its risk factors.",
      "volume": "59",
      "author": "Rutanen",
      "year": "1994",
      "journal-title": "Int J Cancer"
    },
    {
      "key": "2019041122073526200_R46",
      "doi-asserted-by": "crossref",
      "first-page": "168",
      "DOI": "10.1530/acta.0.1280168",
      "article-title": "The expression of insulin-like growth factors and their binding proteins in normal human lymphocytes.",
      "volume": "128",
      "author": "Nyman",
      "year": "1993",
      "journal-title": "Acta Endocrinol (Copenh)"
    },
    {
      "key": "2019041122073526200_R47",
      "doi-asserted-by": "crossref",
      "first-page": "777",
      "DOI": "10.1038/310777a0",
      "article-title": "Insulin-like growth factor II precursor gene organisation in relation to insulin gene family.",
      "volume": "310",
      "author": "Dull",
      "year": "1984",
      "journal-title": "Nature"
    },
    {
      "key": "2019041122073526200_R48",
      "doi-asserted-by": "crossref",
      "first-page": "1176",
      "DOI": "10.1210/mend-2-12-1176",
      "article-title": "Cloning and expression of the growth hormone dependent insulin-like growth factor binding protein.",
      "volume": "2",
      "author": "Wood",
      "year": "1988",
      "journal-title": "Mol Endocrinol"
    }
  ],
  "container-title": "Endocrinology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://academic.oup.com/endo/article-pdf/138/4/1464/10351534/endo1464.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        3,
        21
      ]
    ],
    "date-time": "2022-03-21T22:51:34Z",
    "timestamp": 1647903094000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://academic.oup.com/endo/article/138/4/1464/2987282"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1997,
        4,
        1
      ]
    ]
  },
  "references-count": 48,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          1997,
          4,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1210/endo.138.4.5060",
  "relation": {},
  "ISSN": [
    "0013-7227",
    "1945-7170"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1997,
        4,
        1
      ]
    ]
  }
}