Crossref journal-article
The Endocrine Society
Endocrinology (80)
Bibliography

Gazzerro, E., Pereira, R. C., Jorgetti, V., Olson, S., Economides, A. N., & Canalis, E. (2005). Skeletal Overexpression of Gremlin Impairs Bone Formation and Causes Osteopenia. Endocrinology, 146(2), 655–665.

Authors 6
  1. Elisabetta Gazzerro (first)
  2. Renata C. Pereira (additional)
  3. Vanda Jorgetti (additional)
  4. Sarah Olson (additional)
  5. Aris N. Economides (additional)
  6. Ernesto Canalis (additional)
References 58 Referenced 154
  1. 10.1210/er.2002-0023 / Endocr Rev / Bone morphogenetic proteins, their antagonists and the skeleton. by Canalis (2003)
  2. 10.1093/hmg/10.5.537 / Hum Mol Genet / Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). by Balemans (2001)
  3. 10.1086/318811 / Am J Hum Genet / Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. by Brunkow (2001)
  4. 10.1038/6821 / Nat Genet / Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. by Gong (1999)
  5. 10.1073/pnas.201367598 / Proc Natl Acad Sci USA / Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding. by Marcelino (2001)
  6. 10.1056/NEJM199608223350804 / N Engl J Med / Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. by Shafritz (1996)
  7. 10.1006/dbio.1999.9240 / Dev Biol / A mouse cerberus/Dan-related gene family. by Pearce (1999)
  8. 10.1016/S0092-8674(00)80132-4 / Cell / Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. by Piccolo (1996)
  9. 10.1016/S0092-8674(01)00275-6 / Cell / Twisted perspective: new insights into extracellular modulation of BMP signaling during development. by Ray (2001)
  10. 10.1074/jbc.M006114200 / J Biol Chem / Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-β family. by Tsuchida (2000)
  11. 10.1016/S0092-8674(00)80133-6 / Cell / The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. by Zimmerman (1996)
  12. 10.1016/S1097-2765(00)80067-2 / Mol Cell / The Xenopus dorsalizing factor gremlin identifies a novel family of secreted proteins that antagonize BMP activities. by Hsu (1998)
  13. 10.1074/jbc.275.12.8785 / J Biol Chem / Biosynthesis, post-translation modification, and functional characterization of drm/gremlin. by Topol (2000)
  14. 10.1128/MCB.17.8.4801 / Mol Cell Biol / Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture. by Topol (1997)
  15. 10.1038/ng1178 / Nat Genet / Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. by Khokha (2003)
  16. 10.1242/dev.126.23.5515 / Development / The BMP antagonist gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. by Merino (1999)
  17. 10.1038/44157 / Nature / Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. by Zuniga (1999)
  18. 10.1210/endo.141.12.7851 / Endocrinology / Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts. by Pereira (2000)
  19. 10.1210/en.2002-220918 / Endocrinology / Skeletal overexpression of noggin results in osteopenia and reduced bone formation. by Devlin (2003)
  20. 10.1083/jcb.132.1.195 / J Cell Biol / Increased expression of TGF-β 2 in osteoblasts results in an osteoporosis-like phenotype. by Erlebacher (1996)
  21. {'key': '2019041121290452000_R21', 'author': 'Irwin', 'year': '1989'} by Irwin (1989)
  22. 10.1359/jbmr.2001.16.9.1682 / J Bone Miner Res / Validation of peripheral dual-energy X-ray absorptiometry for the measurement of bone mineral in intact and excised long bones of rates. by Nagy (2001)
  23. 10.1002/jbmr.5650020617 / J Bone Miner Res / Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. by Parfitt (1987)
  24. 10.3109/10520298009067260 / Stain Technol / Staining and histochemistry of undecalcified bone embedded in water-miscible plastic. by Franklin (1980)
  25. 10.1177/002215549704500902 / J Histochem Cytochem / Pre-osteoblastic proliferation assessed with BrdU in undecalcified, epon-embedded adult rat trabecular bone. by Barou (1997)
  26. 10.1016/S8756-3282(98)00041-6 / Bone / Recruitment and proliferative responses of osteoblasts after mechanical loading in vivo determined using sustained-release bromodeoxyuridine. by Turner (1998)
  27. 10.1172/JCI2799 / J Clin Invest / Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. by Weinstein (1998)
  28. 10.1016/S8756-3282(02)00948-1 / Bone / Noggin arrests stromal cell differentiation in vitro. by Gazzerro (2003)
  29. 10.1074/jbc.274.39.27747 / J Biol Chem / Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption. by Choi (1999)
  30. 10.1016/S0014-5793(98)00954-5 / FEBS Lett / The L45 loop in type I receptors for TGF-β family members is a critical determinant in specifying Smad isoform activation. by Persson (1980)
  31. 10.1128/MCB.18.5.2474 / Mol Cell Biol / Wnt-1 induces growth, cytosolic β-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts. by Young (1998)
  32. 10.1152/ajpcell.1999.277.1.C132 / Am J Physiol / Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid by Otsuka (1999)
  33. 10.1083/jcb.200109012 / J Cell Biol / Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. by Zhao (2002)
  34. 10.1210/en.2003-0463 / Endocrinology / Notch 1 impairs osteoblastic cell differentiation. by Sciaudone (2003)
  35. 10.1210/en.2002-220129 / Endocrinology / Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia. by Devlin (2002)
  36. 10.1210/endo.138.5.5105 / Endocrinology / Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effects of age and sex. by Frenkel (1997)
  37. 10.1016/S8756-3282(02)00912-2 / Bone / Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: a comparison between rat type I collagen and rat osteocalcin promoters. by Kalajzic (2002)
  38. 10.1016/0016-5085(91)90827-8 / Gastroenterology / Reciprocity not proven in hepatic blood flow. by Charbon (1991)
  39. 10.1210/endo.141.12.7840 / Endocrinology / The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated. by Gori (2000)
  40. 10.1359/jbmr.2000.15.4.663 / J Bone Miner Res / Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. by Abe (2000)
  41. 10.1128/MCB.24.15.6560-6568.2004 / Mol Cell Biol / Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. by Ogasawara (2004)
  42. 10.1242/jcs.00623 / J Cell Sci / Secreted antagonists of the Wnt signaling pathway. by Kawano (2003)
  43. 10.1101/gad.10.11.1382 / Genes Dev / Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. by Kratochwil (1996)
  44. 10.2106/00004623-200108000-00012 / J Bone Joint Surg Am / Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model by Bouxsein (2001)
  45. 10.1016/S8756-3282(03)00191-1 / Bone / BMP signaling components are expressed in human fracture callus. by Kloen (2003)
  46. 10.1006/dbio.1999.9496 / Dev Biol / In Xenopus embryos, BMP heterodimers are not required for mesoderm induction, but BMP activity is necessary for dorsal/ventral patterning. by Eimon (1999)
  47. 10.1101/gad.9.22.2808 / Genes Dev / BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. by Luo (1995)
  48. 10.1038/sj.gt.3301960 / Gene Ther / Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes. by Park (2003)
  49. 10.1210/endo.138.3.4978 / Endocrinology / Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures. by Varghese (1997)
  50. {'key': '2019041121290452000_R50', 'first-page': '155', 'article-title': 'Skeletal growth factors.', 'volume': '3', 'author': 'Canalis', 'year': '1993', 'journal-title': 'Crit Rev Eukaryot Gene Expr'} / Crit Rev Eukaryot Gene Expr / Skeletal growth factors. by Canalis (1993)
  51. 10.1242/dev.00344 / Development / Cell fate specification and competence by Coco, a maternal BMP, TGF β and Wnt inhibitor. by Bell (2003)
  52. 10.1056/NEJM200205163462011 / N Engl J Med / Regulation of bone formation and vision by LRP5. by Patel (2002)
  53. 10.1086/368277 / Am J Hum Genet / Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. by Van Wesenbeeck (2003)
  54. 10.1210/me.2003-0498 / Mol Endocrinol / The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. by Bodine (2004)
  55. 10.1038/35001602 / Nature / Interaction between Wnt and TGF-β signalling pathways during formation of Spemann’s organizer. by Nishita (2000)
  56. 10.1101/gad.263003 / Genes Dev / Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. by Soshnikova (2003)
  57. 10.1359/jbmr.2003.18.10.1842 / J Bone Miner Res / BMP-2 controls alkaline phosphates expression and osteoblast mineralization by a Wnt autocrine loop. by Rawadi (2003)
  58. {'key': '2019041121290452000_R58', 'first-page': '816', 'article-title': 'Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis.', 'volume': '84', 'author': 'Fischer', 'year': '2002', 'journal-title': 'J Cell Biol'} / J Cell Biol / Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis. by Fischer (2002)
Dates
Type When
Created 20 years, 9 months ago (Nov. 11, 2004, 8:24 p.m.)
Deposited 4 years, 2 months ago (June 28, 2021, 1:45 a.m.)
Indexed 1 month, 3 weeks ago (July 14, 2025, 11:26 p.m.)
Issued 20 years, 7 months ago (Feb. 1, 2005)
Published 20 years, 7 months ago (Feb. 1, 2005)
Published Print 20 years, 7 months ago (Feb. 1, 2005)
Funders 0

None

@article{Gazzerro_2005, title={Skeletal Overexpression of Gremlin Impairs Bone Formation and Causes Osteopenia}, volume={146}, ISSN={1945-7170}, url={http://dx.doi.org/10.1210/en.2004-0766}, DOI={10.1210/en.2004-0766}, number={2}, journal={Endocrinology}, publisher={The Endocrine Society}, author={Gazzerro, Elisabetta and Pereira, Renata C. and Jorgetti, Vanda and Olson, Sarah and Economides, Aris N. and Canalis, Ernesto}, year={2005}, month=feb, pages={655–665} }