DOI: 10.1210/endo.140.11.7118. Pituitary Lactotroph Adenomas Develop after Prolonged Lactotroph Hyperplasia in Dopamine D2 Receptor-Deficient Mice1

Pituitary Lactotroph Adenomas Develop after Prolonged Lactotroph Hyperplasia in Dopamine D2 Receptor-Deficient Mice1

10.1210/endo.140.11.7118

Crossref journal-article

The Endocrine Society

Endocrinology (80)

Abstract

AbstractTuberoinfundibular dopamine tonically inhibits PRL expression and secretion from the pituitary gland by the activation of dopamine D2 receptors (D2R) localized on lactotrophs. Mutant female mice that lack D2Rs have persistent hyperprolactinemia but also develop extensive hyperplasia of pituitary lactotrophs and peliosis of the adenohypophysis at 9 to 12 months of age, while age-matched male D2R-deficient mice have no morphologic adenohypophysial lesion. We now report that both female and male D2R-deficient mice 17 to 20 months of age develop pituitary lactotroph adenomas. Of 12 aged female mice examined, all developed monohormonal PRL-immunoreactive neoplasms that had a characteristic juxtanuclear Golgi pattern of PRL staining and loss of the reticulin fiber network. Several of these adenomas were 50-fold larger than normal glands with marked suprasellar extension and invasion of brain but no gross evidence of distant metastases. They also had striking peliosis that was more marked than the lesion seen in the hyperplastic pituitaries of the younger females. These findings demonstrate that a chronic loss of neurohormonal dopamine inhibition promotes the hyperplasia-neoplasia sequence in adenohypophysial lactotrophs. Our results are analogous to previous data indicating that protracted stimulation of adenohypophysial cells by hormones or growth factors results in proliferation with initial hyperplasia followed by the development of neoplasia. Six aged male D2R-deficient mice had slightly enlarged anterior pituitaries similar in size to normal female glands. However, each case exhibited multifocal, microscopic lactotroph adenomas with strong nuclear immunoreactivity for estrogen receptors and Pit-1 transcription factor. The unexpected development of adenomas in males without preexisting or concomitant hyperplasia suggests that prolonged loss of dopamine inhibition may also cause neoplasia by distinct cellular mechanisms in male and female animals.

Bibliography

Asa, S. L., Kelly, M. A., Grandy, D. K., & Low, M. J. (1999). Pituitary Lactotroph Adenomas Develop after Prolonged Lactotroph Hyperplasia in Dopamine D2 Receptor-Deficient Mice1. Endocrinology, 140(11), 5348â5355.

Authors 4

Sylvia L. Asa (first)
Michele A. Kelly (additional)
David K. Grandy (additional)
Malcolm J. Low (additional)

References 50 Referenced 103

{'key': '2020071620183605200_R1', 'first-page': '798', 'article-title': 'The cytogenesis and pathogenesis of pituitary adenomas.', 'volume': '19', 'author': 'Asa', 'year': '1998', 'journal-title': 'Endocr Rev'} / Endocr Rev / The cytogenesis and pathogenesis of pituitary adenomas. by Asa (1998)
10.1210/jcem-67-4-713 / J Clin Endocrinol Metab / Morphological evidence for the presence of arteries in human prolactinomas. by Schechter (1988)
{'key': '2020071620183605200_R3', 'first-page': '360', 'article-title': 'Prolactin cells in the human pituitary. A quantitative immunocytochemical analysis.', 'volume': '106', 'author': 'Asa', 'year': '1982', 'journal-title': 'Arch Pathol Lab Med'} / Arch Pathol Lab Med / Prolactin cells in the human pituitary. A quantitative immunocytochemical analysis. by Asa (1982)
10.1007/BF00432405 / Virchows Arch [Pathol Anat] / Die Morphologie der paraadenomatösen Adenohypophyse. Ein Beitrag zur Pathogenese der Hypophysenadenome. by Saeger (1977)
10.1007/BF00612945 / Virchows Arch [A] / Pituitary hyperplasia. Definition, light and electron microscopical structures and significance in surgical specimens. by Saeger (1983)
10.1159/000124760 / Neuroendocrinology / Dual action of dopamine on growth hormone release in vitro. by Serri (1987)
10.1677/joe.0.1270191 / J Endocrinol / Involvement of dopamine D1 receptors in the control of growth hormone secretion in the rat. by Bluet-Pajot (1990)
10.1210/jcem-55-3-589 / J Clin Endocrinol Metab / Evidence of dopamine receptors in human growth hormone (GH)-secreting adenomas with concomitant study of dopamine inhibition of GH secretion in a perfusion system. by Bression (1982)
10.1530/acta.0.1030446 / Acta Endocrinol (Copenh) / The role of prolactin in the inhibitory action of bromocriptine on growth hormone secretion in acromegaly. by Lamberts (1983)
{'key': '2020071620183605200_R10', 'first-page': '411', 'article-title': 'Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas.', 'volume': '78', 'author': 'Spada', 'year': '1994', 'journal-title': 'J Clin Endocrinol Metab'} / J Clin Endocrinol Metab / Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas. by Spada (1994)
10.1210/endo.135.1.8013363 / Endocrinology / Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype. by Missale (1994)
10.1016/S0896-6273(00)80351-7 / Neuron / Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. by Kelly (1997)
10.1523/JNEUROSCI.18-09-03470.1998 / J Neurosci / Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. by Kelly (1998)
{'key': '2020071620183605200_R14', 'author': 'Asa', 'year': '1998'} by Asa (1998)
10.1210/endo.131.5.1425411 / Endocrinology / Pituitary adenomas in mice transgenic for growth hormone-releasing hormone. by Asa (1992)
{'key': '2020071620183605200_R16', 'first-page': '895', 'article-title': 'Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis.', 'volume': '141', 'author': 'Lloyd', 'year': '1992', 'journal-title': 'Am J Pathol'} / Am J Pathol / Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis. by Lloyd (1992)
10.1016/S0889-8529(18)30462-6 / Endocrinol Metab Clin North Am / Pathogenesis of pituitary tumors. by Molitch (1987)
10.1210/endo-126-6-3185 / Endocrinology / Prolactin-releasing factor: cellular origin in the intermediate lobe of the pituitary. by Laudon (1990)
10.1038/30515 / Nature / A prolactin-releasing peptide in the brain. by Hinuma (1998)
10.1016/S0025-6196(12)60946-X / Mayo Clin Proc / The pituitary gland in pregnancy: a clinicopathologic and immunohistochemical study of 69 cases. by Scheithauer (1990)
{'key': '2020071620183605200_R21', 'first-page': '201', 'author': 'Furth', 'year': '1973'} by Furth (1973)
10.1073/pnas.95.21.12671 / Proc Natl Acad Sci USA / Galanin regulates prolactin release and lactotroph proliferation. by Wynick (1998)
10.1136/bmj.290.6463.182 / Br Med J / Prolactinomas. by Grossman (1985)
10.1016/S0015-0282(16)48310-X / Fertil Steril / Diagnosis and management of prolactinomas. by Blackwell (1985)
10.1111/j.1365-2265.1991.tb00928.x / Clin Endocrinol (Oxf) / Dopamine, the dopamine D2 receptor and pituitary tumours. by Wood (1991)
10.1530/acta.0.1140595 / Acta Endocrinol (Copenh) / Demonstration of specific dopamine receptors on human pituitary adenomas. by Koga (1987)
10.1016/S0021-9258(18)61275-X / J Biol Chem / The D2 receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. by Senogles (1987)
10.1210/jcem-69-3-500 / J Clin Endocrinol Metab / Resistance to bromocriptine in prolactinomas. by Pellegrini (1989)
10.1111/j.1365-2265.1989.tb00454.x / Clin Endocrinology (Oxf) / Studies of two thyrotrophin-secreting pituitary adenomas: evidence for dopamine receptor deficiency. by Bevan (1989)
{'key': '2020071620183605200_R30', 'first-page': '568', 'article-title': 'Normal structural dopamine type 2 receptor gene in prolactin-secreting and other pituitary tumors.', 'volume': '78', 'author': 'Friedman', 'year': '1994', 'journal-title': 'J Clin Endocrinol Metab'} / J Clin Endocrinol Metab / Normal structural dopamine type 2 receptor gene in prolactin-secreting and other pituitary tumors. by Friedman (1994)
10.1677/joe.0.1080399 / J Endocrinol / Prolactin release, oestrogens and proliferation of prolactin-secreting cells in the anterior pituitary gland of adult male rats. by Pérez (1986)
10.1677/joe.0.1340241 / J Endocrinol / Influence of lactotroph cell density on prolactin secretion in rats. by Pasolli (1992)
{'key': '2020071620183605200_R33', 'first-page': '521', 'article-title': 'Effect of estrogen and neuroleptics on prolactin secretion and immunoreactive prolactin cells.', 'volume': '29', 'author': 'Oliveira', 'year': '1996', 'journal-title': 'Braz J Med Biol Res'} / Braz J Med Biol Res / Effect of estrogen and neuroleptics on prolactin secretion and immunoreactive prolactin cells. by Oliveira (1996)
10.1210/jcem.83.2.4556 / J Clin Endocrinol Metab / Cabergoline in the treatment of acromegaly: a study in 64 patients. by Abs (1998)
10.1007/BF03348476 / J Endocrinol Invest / In vitro studies on TSH secretion and adenylate cyclase activity in a human TSH-secreting pituitary adenoma. Effects of somatostatin and dopamine. by Spada (1985)
10.1016/S0344-0338(88)80019-0 / Pathol Res Pract / The TSH secretion in the human pituitary adenomas. by Trouillas (1988)
10.1210/jcem-61-3-580 / J Clin Endocrinol Metab / Follicle-stimulating hormone- and α-subunit-secreting pituitary tumor treated with bromocriptine. by Vance (1985)
10.1210/jcem-66-1-96 / J Clin Endocrinol Metab / Dopaminergic regulation of α-subunit secretion and messenger ribonucleic acid levels in α-secreting pituitary tumors. by Klibanski (1988)
10.1210/jcem-64-3-524 / J Clin Endocrinol Metab / The effects of bromocriptine, thyrotropin-releasing hormone, and gonadotropin-releasing hormone on hormone secretion by gonadotropin-secreting pituitary adenomas in vivo and in vitro. by Lamberts (1987)
{'key': '2020071620183605200_R40', 'first-page': '1005', 'author': 'Asa', 'year': '1991'} by Asa (1991)
10.1002/1097-0142(197706)39:6<2716::AID-CNCR2820390659>3.0.CO;2-3 / Cancer / The role of hormones in the etiology of human breast cancer. by Kirschner (1977)
{'key': '2020071620183605200_R42', 'first-page': '1', 'article-title': 'Risk factors in endometrial carcinoma with special reference to the use of estrogens.', 'volume': '86', 'author': 'Salmi', 'year': '1979', 'journal-title': 'Acta Obstet Gynecol Scand [Suppl]'} / Acta Obstet Gynecol Scand [Suppl] / Risk factors in endometrial carcinoma with special reference to the use of estrogens. by Salmi (1979)
10.1016/S0022-5347(17)43855-9 / J Urol / New methods of endocrine management in prostatic cancer. by Smith Jr (1987)
10.1016/S0300-595X(79)80017-1 / Clin Endocrinol Metab / The aetiology of thyroid tumours. by Williams (1979)
{'key': '2020071620183605200_R45', 'author': 'Neville'} by Neville
10.1016/S0022-5347(17)58421-9 / J Urol / Testicular tumors associated with congenital adrenal hyperplasia: a continuing diagnostic and therapeutic dilemma. by Newell (1977)
10.1093/ajcp/38.1.52 / Am J Clin Pathol / Sertoli cell adenomas in patients with testicular feminization. by Neubecker (1962)
10.3109/00365598409182168 / Scand J Urol Nephrol / Histological changes in parathyroid glands in subclinical and clinical renal disease. An autopsy investigation. by Akerström (1984)
10.1056/NEJM198112033052304 / N Engl J Med / Chemical carcinogenesis. by Farber (1981)
10.1210/endo.136.10.7664668 / Endocrinology / Targeting of transforming growth factor-α expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas. by McAndrew (1995)

Dates

Type	When
Created	11 years, 7 months ago (Jan. 8, 2014, 11:09 a.m.)
Deposited	3 years, 5 months ago (March 21, 2022, 7:04 p.m.)
Indexed	3 weeks, 1 day ago (Aug. 6, 2025, 8:58 a.m.)
Issued	25 years, 9 months ago (Nov. 1, 1999)
Published	25 years, 9 months ago (Nov. 1, 1999)
Published Print	25 years, 9 months ago (Nov. 1, 1999)

Funders 0

None

BibTeX

@article{Asa_1999, title={Pituitary Lactotroph Adenomas Develop after Prolonged Lactotroph Hyperplasia in Dopamine D2 Receptor-Deficient Mice1}, volume={140}, ISSN={1945-7170}, url={http://dx.doi.org/10.1210/endo.140.11.7118}, DOI={10.1210/endo.140.11.7118}, number={11}, journal={Endocrinology}, publisher={The Endocrine Society}, author={Asa, Sylvia L. and Kelly, Michele A. and Grandy, David K. and Low, Malcolm J.}, year={1999}, month=nov, pages={5348–5355} }

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      "author": "Saeger",
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      "author": "Grossman",
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      "journal-title": "Br Med J"
    },
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      "key": "2020071620183605200_R24",
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      "article-title": "Diagnosis and management of prolactinomas.",
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      "author": "Blackwell",
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      "author": "Wood",
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      "author": "Koga",
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      "journal-title": "Acta Endocrinol (Copenh)"
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      "volume": "262",
      "author": "Senogles",
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      "journal-title": "J Biol Chem"
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      "first-page": "500",
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      "article-title": "Resistance to bromocriptine in prolactinomas.",
      "volume": "69",
      "author": "Pellegrini",
      "year": "1989",
      "journal-title": "J Clin Endocrinol Metab"
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      "first-page": "59",
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      "article-title": "Studies of two thyrotrophin-secreting pituitary adenomas: evidence for dopamine receptor deficiency.",
      "volume": "31",
      "author": "Bevan",
      "year": "1989",
      "journal-title": "Clin Endocrinology (Oxf)"
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      "first-page": "568",
      "article-title": "Normal structural dopamine type 2 receptor gene in prolactin-secreting and other pituitary tumors.",
      "volume": "78",
      "author": "Friedman",
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      "volume": "108",
      "author": "Pe\u0301rez",
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      "journal-title": "J Endocrinol"
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      "first-page": "241",
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      "article-title": "Influence of lactotroph cell density on prolactin secretion in rats.",
      "volume": "134",
      "author": "Pasolli",
      "year": "1992",
      "journal-title": "J Endocrinol"
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      "first-page": "521",
      "article-title": "Effect of estrogen and neuroleptics on prolactin secretion and immunoreactive prolactin cells.",
      "volume": "29",
      "author": "Oliveira",
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      "author": "Abs",
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      "volume": "8",
      "author": "Spada",
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      "journal-title": "J Endocrinol Invest"
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      "author": "Trouillas",
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      "author": "Vance",
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      "author": "Kirschner",
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      "author": "Salmi",
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      "author": "Smith Jr",
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      "journal-title": "J Urol"
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      "author": "Williams",
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      "journal-title": "Clin Endocrinol Metab"
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      "author": "Neubecker",
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      "author": "Farber",
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