DOI: 10.1196/annals.1402.018. Osteocytes as Dynamic Multifunctional Cells

Osteocytes as Dynamic Multifunctional Cells

10.1196/annals.1402.018

Crossref journal-article

Wiley

Annals of the New York Academy of Sciences (311)

Abstract

Abstract: The target of bone systemic factors and therapeutics has been assumed to be primarily osteoblasts and/or osteoclasts and their precursors. All the action with regard to bone modeling or remodeling has been assumed to take place on the bone surface. In this scenario, cells below the bone surface, that is, osteocyte, are considered to be inactive placeholders in the bone matrix. New data show osteocytes are involved. In addition to the function of osteocytes translating mechanical strain into biochemical signals between osteocytes and cells on the bone surface to affect (re)modeling, new functions are emerging. Osteocytes are exquisitely sensitive to mechanical strain in the form of shear stress compared to osteoblasts or osteoclasts and communicate with each other, with cells on the bone surface, and with marrow cells. Osteocytes are able to move their cell body and their dendritic processes and appear to be able to modify their local microenvironment. A novel function now attributed to osteocytes includes regulation of phosphate metabolism. Therefore, in addition to osteoblasts and osteoclasts, osteocytes are also important for bone health.

Bibliography

BONEWALD, L. F. (2007). Osteocytes as Dynamic Multifunctional Cells. Annals of the New York Academy of Sciences, 1116(1), 281â290. Portico.

Authors 1

LYNDA F. BONEWALD (first)

References 52 Referenced 331

{'key': 'e_1_2_6_2_2', 'volume-title': 'The Osteocyte', 'author': 'Bonewald L.', 'year': '2007'} / The Osteocyte by Bonewald L. (2007)
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{'key': 'e_1_2_6_35_2', 'first-page': '358', 'article-title': 'Downregulation of SOST/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes', 'volume': '6', 'author': 'Bellido T.', 'year': '2006', 'journal-title': 'J. Musculoskelet. Neuronal Interact.'} / J. Musculoskelet. Neuronal Interact. / Downregulation of SOST/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes by Bellido T. (2006)
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{'key': 'e_1_2_6_53_2', 'first-page': '354', 'article-title': 'Mechanical stimulation in vivo reduces osteocyte expression of sclerostin', 'volume': '6', 'author': 'Robling A.G.', 'year': '2006', 'journal-title': 'J. Musculoskelet. Neuronal Interact.'} / J. Musculoskelet. Neuronal Interact. / Mechanical stimulation in vivo reduces osteocyte expression of sclerostin by Robling A.G. (2006)

Dates

Type	When
Created	17 years, 8 months ago (Dec. 14, 2007, 2:53 p.m.)
Deposited	1 year, 11 months ago (Sept. 25, 2023, 1:28 a.m.)
Indexed	2 days, 10 hours ago (Aug. 28, 2025, 8:51 a.m.)
Issued	17 years, 9 months ago (Nov. 1, 2007)
Published	17 years, 9 months ago (Nov. 1, 2007)
Published Online	17 years, 8 months ago (Dec. 13, 2007)
Published Print	17 years, 9 months ago (Nov. 1, 2007)

Funders 0

None

BibTeX

@article{BONEWALD_2007, title={Osteocytes as Dynamic Multifunctional Cells}, volume={1116}, ISSN={1749-6632}, url={http://dx.doi.org/10.1196/annals.1402.018}, DOI={10.1196/annals.1402.018}, number={1}, journal={Annals of the New York Academy of Sciences}, publisher={Wiley}, author={BONEWALD, LYNDA F.}, year={2007}, month=nov, pages={281–290} }

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