DOI: 10.1196/annals.1355.025. TLR2 Is Necessary to Inflammatory Response in <i>Coxiella burnetii</i> Infection

TLR2 Is Necessary to Inflammatory Response in Coxiella burnetii Infection

10.1196/annals.1355.025

Crossref journal-article

Wiley

Annals of the New York Academy of Sciences (311)

Abstract

Abstract: The resolution of Q fever, a zoonosis caused by Coxiella burnetii, depends on efficient innate and adaptive immune responses. Such responses are influenced by Toll‐like receptors (TLRs). TLR4 is involved only in part in immune responses against C. burnetii, suggesting a role for TLR2. We investigated C. burnetii infection in wild‐type and TLR2−/− mice. C. burnetii organisms were similarly eliminated by wild‐type and TLR2−/− mice. In contrast, the formation of granulomas, a marker for efficient cell‐mediated immunity, was markedly impaired. These results show that TLR2 is required for inflammatory and immune response to C. burnetii, but is dispensable for bacterial clearance.

Bibliography

MEGHARI, S., HONSTETTRE, A., LEPIDI, H., RYFFEL, B., RAOULT, D., & MEGE, J. (2005). TLR2 Is Necessary to Inflammatory Response in Coxiella burnetii Infection. Annals of the New York Academy of Sciences, 1063(1), 161â166. Portico.

Authors 6

SORAYA MEGHARI (first)
AMÉLIE HONSTETTRE (additional)
HUBERT LEPIDI (additional)
BERNARDT RYFFEL (additional)
DIDIER RAOULT (additional)
JEAN‐LOUIS MEGE (additional)

References 15 Referenced 32

Dates

Type	When
Created	19 years, 6 months ago (Feb. 15, 2006, 2:58 p.m.)
Deposited	1 year, 11 months ago (Sept. 25, 2023, 8:18 p.m.)
Indexed	2 months, 1 week ago (June 19, 2025, 10:43 a.m.)
Issued	19 years, 9 months ago (Dec. 1, 2005)
Published	19 years, 9 months ago (Dec. 1, 2005)
Published Online	19 years, 5 months ago (March 29, 2006)
Published Print	19 years, 9 months ago (Dec. 1, 2005)

Funders 0

None

BibTeX

@article{MEGHARI_2005, title={TLR2 Is Necessary to Inflammatory Response in Coxiella burnetii Infection}, volume={1063}, ISSN={1749-6632}, url={http://dx.doi.org/10.1196/annals.1355.025}, DOI={10.1196/annals.1355.025}, number={1}, journal={Annals of the New York Academy of Sciences}, publisher={Wiley}, author={MEGHARI, SORAYA and HONSTETTRE, AMÉLIE and LEPIDI, HUBERT and RYFFEL, BERNARDT and RAOULT, DIDIER and MEGE, JEAN‐LOUIS}, year={2005}, month=dec, pages={161–166} }

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