DOI: 10.1189/jlb.71.1.133. Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning

Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning

10.1189/jlb.71.1.133

Crossref journal-article

Oxford University Press (OUP)

Journal of Leukocyte Biology (286)

Abstract

AbstractCD93 is a ∼120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. So far, its primary structure and function were unknown. We used retroviral-expression cloning to isolate the CD93 cDNA. Sequence analysis revealed that CD93 is identical to a protein on human phagocytes termed C1q receptor (C1qRp). C1qRp was shown previously to mediate enhancement of phagocytosis in monocytes and was suggested to be a receptor of C1q and two other structurally related molecules. When studying CD93 transductants and control cells, we found that cells expressing CD93 have enhanced capacity to bind C1q. Furthermore, we show that immature dendritic cells (DC) express CD93/C1qRp, and mature DC, known to have reduced capacity for antigen uptake and to have lost the ability to phagocytose, show weak-to-negative CD93/C1qRp expression.

Bibliography

Steinberger, P., Szekeres, A., Wille, S., StÃ¶ckl, J., Selenko, N., Prager, E., Staffler, G., Madic, O., Stockinger, H., & Knapp, W. (2002). Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. Journal of Leukocyte Biology, 71(1), 133â140.

Authors 10

Peter Steinberger (first)
Andreas Szekeres (additional)
Stefan Wille (additional)
Johannes Stöckl (additional)
Nicole Selenko (additional)
Elisabeth Prager (additional)
Günther Staffler (additional)
Otto Madic (additional)
Hannes Stockinger (additional)
Walter Knapp (additional)

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Dates

Type	When
Created	2 years, 11 months ago (Sept. 27, 2022, 9:25 p.m.)
Deposited	1 year, 9 months ago (Nov. 27, 2023, 4:46 p.m.)
Indexed	1 month, 3 weeks ago (July 16, 2025, 7:44 a.m.)
Issued	23 years, 8 months ago (Jan. 1, 2002)
Published	23 years, 8 months ago (Jan. 1, 2002)
Published Online	23 years, 8 months ago (Jan. 1, 2002)
Published Print	23 years, 8 months ago (Jan. 1, 2002)

Funders 2

Austrian Science Fund 10.13039/501100002428
Region: Europe
gov (National government)
Labels8
1. Fonds zur Förderung der Wissenschaftlichen Forschung
2. FWF Der Wissenschaftsfonds
3. FWF Austrian Science Fund
4. Der Wissenschaftsfonds FWF
5. Österreichischer Wissenschaftsfonds
6. FWF
7. FFWF
8. FWF EN
Awards1
1. SFB005.2
Competence Center “Bio-Molecular Therapeutics

BibTeX

@article{Steinberger_2002, title={Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning}, volume={71}, ISSN={1938-3673}, url={http://dx.doi.org/10.1189/jlb.71.1.133}, DOI={10.1189/jlb.71.1.133}, number={1}, journal={Journal of Leukocyte Biology}, publisher={Oxford University Press (OUP)}, author={Steinberger, Peter and Szekeres, Andreas and Wille, Stefan and Stöckl, Johannes and Selenko, Nicole and Prager, Elisabeth and Staffler, Günther and Madic, Otto and Stockinger, Hannes and Knapp, Walter}, year={2002}, month=jan, pages={133–140} }

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