Interferon-γ: an overview of signals, mechanisms and functions
10.1189/jlb.0603252
Crossref journal-article
Oxford University Press (OUP)
Journal of Leukocyte Biology (286)
Abstract

AbstractInterferon-γ (IFN-γ) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-γ ligand, receptor, ignal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophage function during infection. The current model for IFN-γ signal transduction is discussed, as well as signal regulation and factors conferring signal specificity. Cellular effects of IFN-γ are described, including up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-α, interleukin-4, type I IFNs, and lipopolysaccharide are discussed.

Bibliography

Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2003). Interferon-γ: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 75(2), 163–189.

Authors 4
  1. Kate Schroder (first)
  2. Paul J Hertzog (additional)
  3. Timothy Ravasi (additional)
  4. David A Hume (additional)
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Dates
Type When
Created 21 years, 10 months ago (Oct. 6, 2003, 8:16 p.m.)
Deposited 2 years, 4 months ago (April 26, 2023, 9:52 p.m.)
Indexed 1 day, 19 hours ago (Sept. 4, 2025, 10:25 a.m.)
Issued 21 years, 11 months ago (Oct. 2, 2003)
Published 21 years, 11 months ago (Oct. 2, 2003)
Published Online 21 years, 11 months ago (Oct. 2, 2003)
Published Print 21 years, 7 months ago (Feb. 1, 2004)
Funders 0

None

@article{Schroder_2003, title={Interferon-γ: an overview of signals, mechanisms and functions}, volume={75}, ISSN={1938-3673}, url={http://dx.doi.org/10.1189/jlb.0603252}, DOI={10.1189/jlb.0603252}, number={2}, journal={Journal of Leukocyte Biology}, publisher={Oxford University Press (OUP)}, author={Schroder, Kate and Hertzog, Paul J and Ravasi, Timothy and Hume, David A}, year={2003}, month=oct, pages={163–189} }