Genital and cutaneous human papillomavirus (HPV) types in relation to conjunctival squamous cell neoplasia: A case-control study in Uganda
10.1186/1750-9378-3-12
Crossref journal-article
Springer Science and Business Media LLC
Infectious Agents and Cancer (297)
Abstract

Abstract Background We investigated the role of infection with genital and cutaneous human papillomavirus types (HPV) in the aetiology of ocular surface squamous neoplasia (which includes both conjunctival intraepithelial neoplasia (CIN) and carcinoma) using data and biological material collected as part of a case-control study in Uganda. Results Among 81 cases, the prevalence of genital and cutaneous HPV types in tumour tissue did not differ significantly by histological grade of the lesion. The prevalence of genital HPV types did not differ significantly between cases and controls (both 38%; Odds ratio [OR] 1.0, 95% confidence interval [CI] 0.4–2.7, p = 1.0). The prevalence of cutaneous HPV types was 22% (18/81) among cases and 3% (1/29) among controls (OR 8.0, 95% CI 1.0–169, p = 0.04). Conclusion We find no evidence of an association between genital HPV types and ocular surface squamous neoplasia. The prevalence of cutaneous HPV was significantly higher among cases as compared to controls. Although consistent with results from two other case-control studies, the relatively low prevalence of cutaneous HPV types among cases (which does not differ by histological grade of tumour) indicates that there remains considerable uncertainty about a role for cutaneous HPV in the aetiology of this tumour.

Bibliography

de Koning, M. N., Waddell, K., Magyezi, J., Purdie, K., Proby, C., Harwood, C., Lucas, S., Downing, R., Quint, W. G., & Newton, R. (2008). Genital and cutaneous human papillomavirus (HPV) types in relation to conjunctival squamous cell neoplasia: A case-control study in Uganda. Infectious Agents and Cancer, 3(1).

Authors 10
  1. Maurits NC de Koning (first)
  2. Keith Waddell (additional)
  3. Joseph Magyezi (additional)
  4. Karin Purdie (additional)
  5. Charlotte Proby (additional)
  6. Catherine Harwood (additional)
  7. Sebastian Lucas (additional)
  8. Robert Downing (additional)
  9. Wim GV Quint (additional)
  10. Robert Newton (additional)
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Dates
Type When
Created 16 years, 11 months ago (Sept. 10, 2008, 2:13 p.m.)
Deposited 3 years, 11 months ago (Aug. 31, 2021, 7:59 p.m.)
Indexed 1 month ago (July 26, 2025, 4:46 a.m.)
Issued 16 years, 11 months ago (Sept. 10, 2008)
Published 16 years, 11 months ago (Sept. 10, 2008)
Published Online 16 years, 11 months ago (Sept. 10, 2008)
Published Print 16 years, 8 months ago (Dec. 1, 2008)
Funders 0

None

@article{de_Koning_2008, title={Genital and cutaneous human papillomavirus (HPV) types in relation to conjunctival squamous cell neoplasia: A case-control study in Uganda}, volume={3}, ISSN={1750-9378}, url={http://dx.doi.org/10.1186/1750-9378-3-12}, DOI={10.1186/1750-9378-3-12}, number={1}, journal={Infectious Agents and Cancer}, publisher={Springer Science and Business Media LLC}, author={de Koning, Maurits NC and Waddell, Keith and Magyezi, Joseph and Purdie, Karin and Proby, Charlotte and Harwood, Catherine and Lucas, Sebastian and Downing, Robert and Quint, Wim GV and Newton, Robert}, year={2008}, month=sep }