The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor
10.1186/1471-2202-3-15
Crossref journal-article
Springer Science and Business Media LLC
BMC Neuroscience (297)
Bibliography

Takano, H., & Gusella, J. F. (2002). The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor. BMC Neuroscience, 3(1).

Authors 2
  1. Hiroki Takano (first)
  2. James F Gusella (additional)
References 49 Referenced 121
  1. Martin JB, Gusella JF: Huntington's disease. Pathogenesis and management. N Engl J Med. 1986, 315: 1267-1276. (10.1056/NEJM198611133152006) / N Engl J Med by JB Martin (1986)
  2. Huntington's Disease Collaborative Research Group: A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell. 1993, 72: 971-983. 10.1016/0092-8674(93)90585-E. (10.1016/0092-8674(93)90585-E) / Cell by Huntington's Disease Collaborative Research Group (1993)
  3. Gusella JF, MacDonald ME: Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease. Nat Rev Neurosci. 2000, 1: 109-115. 10.1038/35039051. (10.1038/35039051) / Nat Rev Neurosci by JF Gusella (2000)
  4. Leavitt BR, Guttman JA, Hodgson JG, Kimel GH, Singaraja R, Vogl AW, Hayden MR: Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo. Am J Hum Genet. 2001, 68: 313-324. 10.1086/318207. (10.1086/318207) / Am J Hum Genet by BR Leavitt (2001)
  5. Cattaneo E, Rigamonti D, Goffredo D, Zuccato C, Squitieri F, Sipione S: Loss of normal huntingtin function: new developments in Huntington's disease research. Trends Neurosci. 2001, 24: 182-188. 10.1016/S0166-2236(00)01721-5. (10.1016/S0166-2236(00)01721-5) / Trends Neurosci by E Cattaneo (2001)
  6. Velier J, Kim M, Schwarz C, Kim TW, Sapp E, Chase K, Aronin N, DiFiglia M: Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp Neurol. 1998, 152: 34-40. 10.1006/exnr.1998.6832. (10.1006/exnr.1998.6832) / Exp Neurol by J Velier (1998)
  7. White JK, Auerbach W, Duyao MP, Vonsattel JP, Gusella JF, Joyner AL, MacDonald ME: Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nat Genet. 1997, 17: 404-410. 10.1038/ng1297-404. (10.1038/ng1297-404) / Nat Genet by JK White (1997)
  8. Hilditch-Maguire P, Trettel F, Passani LA, Auerbach A, Persichetti F, MacDonald ME: Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hum Mol Genet. 2000, 9: 2789-2797. 10.1093/hmg/9.19.2789. (10.1093/hmg/9.19.2789) / Hum Mol Genet by P Hilditch-Maguire (2000)
  9. Dragatsis I, Levine MS, Zeitlin S: Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat Genet. 2000, 26: 300-306. 10.1038/81593. (10.1038/81593) / Nat Genet by I Dragatsis (2000)
  10. Andrade MA, Bork P: HEAT repeats in the Huntington's disease protein. Nat Genet. 1995, 11: 115-116. 10.1038/ng1095-115. (10.1038/ng1095-115) / Nat Genet by MA Andrade (1995)
  11. Vetter IR, Arndt A, Kutay U, Gorlich D, Wittinghofer A: Structural view of the Ran-Importin beta interaction at 2.3 A resolution. Cell. 1999, 97: 635-646. 10.1016/S0092-8674(00)80774-6. (10.1016/S0092-8674(00)80774-6) / Cell by IR Vetter (1999)
  12. Cingolani G, Lashuel HA, Gerace L, Muller CW: Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association. FEBS Lett. 2000, 484: 291-298. 10.1016/S0014-5793(00)02154-2. (10.1016/S0014-5793(00)02154-2) / FEBS Lett by G Cingolani (2000)
  13. Cingolani G, Petosa C, Weis K, Muller CW: Structure of importin-beta bound to the IBB domain of importin-alpha. Nature. 1999, 399: 221-229. 10.1038/20367. (10.1038/20367) / Nature by G Cingolani (1999)
  14. Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D: The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell. 1999, 96: 99-110. 10.1016/S0092-8674(00)80963-0. (10.1016/S0092-8674(00)80963-0) / Cell by MR Groves (1999)
  15. Groves MR, Barford D: Topological characteristics of helical repeat proteins. Curr Opin Struct Biol. 1999, 9: 383-389. 10.1016/S0959-440X(99)80052-9. (10.1016/S0959-440X(99)80052-9) / Curr Opin Struct Biol by MR Groves (1999)
  16. Chook YM, Blobel G: Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. Nature. 1999, 399: 230-237. 10.1038/20375. (10.1038/20375) / Nature by YM Chook (1999)
  17. Huntington's Disease Collaborative Research Group: A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell. 1993, 72: 971-983. 10.1016/0092-8674(93)90585-E. (10.1016/0092-8674(93)90585-E) / Cell by Huntington's Disease Collaborative Research Group (1993)
  18. Jones L: Huntingtin-interacting proteins an their relevance to Huntington's disease etiology. Neuroscience News. 2000, 3: 55-63. / Neuroscience News by L Jones (2000)
  19. Gusella JF, MacDonald ME: Huntingtin: a single bait hooks many species. Curr Opin Neurobiol. 1998, 8: 425-430. 10.1016/S0959-4388(98)80071-8. (10.1016/S0959-4388(98)80071-8) / Curr Opin Neurobiol by JF Gusella (1998)
  20. Eisenberg D, Marcotte EM, Xenarios I, Yeates TO: Protein function in the post-genomic era. Nature. 2000, 405: 823-826. 10.1038/35015694. (10.1038/35015694) / Nature by D Eisenberg (2000)
  21. Marcotte EM, Xenarios I, van Der Bliek AM, Eisenberg D: Localizing proteins in the cell from their phylogenetic profiles. Proc Natl Acad Sci U S A. 2000, 97: 12115-12120. 10.1073/pnas.220399497. (10.1073/pnas.220399497) / Proc Natl Acad Sci U S A by EM Marcotte (2000)
  22. Foo SY, Nolan GP: NF-kappaB to the rescue: RELs, apoptosis and cellular transformation. Trends Genet. 1999, 15: 229-235. 10.1016/S0168-9525(99)01719-9. (10.1016/S0168-9525(99)01719-9) / Trends Genet by SY Foo (1999)
  23. Denk A, Wirth T, Baumann B: NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival. Cytokine Growth Factor Rev. 2000, 11: 303-320. 10.1016/S1359-6101(00)00009-5. (10.1016/S1359-6101(00)00009-5) / Cytokine Growth Factor Rev by A Denk (2000)
  24. Qiu P, Pan PC, Govind S: A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis. Development. 1998, 125: 1909-1920. (10.1242/dev.125.10.1909) / Development by P Qiu (1998)
  25. Metzler M, Helgason CD, Dragatsis I, Zhang T, Gan L, Pineault N, Zeitlin SO, Humphries RK, Hayden MR: Huntingtin is required for normal hematopoiesis. Hum Mol Genet. 2000, 9: 387-394. 10.1093/hmg/9.3.387. (10.1093/hmg/9.3.387) / Hum Mol Genet by M Metzler (2000)
  26. Bhaskar V, Valentine SA, Courey AJ: A functional interaction between dorsal and components of the Smt3 conjugation machinery. J Biol Chem. 2000, 275: 4033-4040. 10.1074/jbc.275.6.4033. (10.1074/jbc.275.6.4033) / J Biol Chem by V Bhaskar (2000)
  27. Wu LP, Anderson KV: Regulated nuclear import of Rel proteins in the Drosophila immune response. Nature. 1998, 392: 93-97. 10.1038/32195. (10.1038/32195) / Nature by LP Wu (1998)
  28. Reichhart JM, Georgel P, Meister M, Lemaitre B, Kappler C, Hoffmann JA: Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila. C R Acad Sci III. 1993, 316: 1218-1224. / C R Acad Sci III by JM Reichhart (1993)
  29. Reuther GW, Buss JE, Quilliam LA, Clark GJ, Der CJ: Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences. Methods Enzymol. 2000, 327: 331-350. (10.1016/S0076-6879(00)27288-1) / Methods Enzymol by GW Reuther (2000)
  30. Uv AE, Roth P, Xylourgidis N, Wickberg A, Cantera R, Samakovlis C: members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation. Genes Dev. 2000, 14: 1945-1957. (10.1101/gad.14.15.1945) / Genes Dev by AE Uv (2000)
  31. Brand AH, Perrimon N: Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 1993, 118: 401-415. (10.1242/dev.118.2.401) / Development by AH Brand (1993)
  32. Usui T, Shima Y, Shimada Y, Hirano S, Burgess RW, Schwarz TL, Takeichi M, Uemura T: Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell. 1999, 98: 585-595. 10.1016/S0092-8674(00)80046-X. (10.1016/S0092-8674(00)80046-X) / Cell by T Usui (1999)
  33. Li Z, Karlovich CA, Fish MP, Scott MP, Myers RM: A putative Drosophila homolog of the Huntington's disease gene. Hum Mol Genet. 1999, 8: 1807-1815. 10.1093/hmg/8.9.1807. (10.1093/hmg/8.9.1807) / Hum Mol Genet by Z Li (1999)
  34. Bailey TL, Elkan C: Fitting a mixture model by expectation maximization to discover motifs in biopolymers. In: Second International Conference on Intelligent Systems for Molecular Biology; Menlo Park, California. 1994, 28-36. / In: Second International Conference on Intelligent Systems for Molecular Biology; Menlo Park, California by TL Bailey (1994)
  35. Bailey TL, Gribskov M: Combining evidence using p-values: application to sequence homology searches. Bioinformatics. 1998, 14: 48-54. 10.1093/bioinformatics/14.1.48. (10.1093/bioinformatics/14.1.48) / Bioinformatics by TL Bailey (1998)
  36. Andrade MA, Petosa C, O'Donoghue SI, Muller CW, Bork P: Comparison of ARM and HEAT protein repeats. J Mol Biol. 2001, 309: 1-18. 10.1006/jmbi.2001.4624. (10.1006/jmbi.2001.4624) / J Mol Biol by MA Andrade (2001)
  37. Andrade MA, Ponting CP, Gibson TJ, Bork P: Homology-based method for identification of protein repeats using statistical significance estimates. J Mol Biol. 2000, 298: 521-537. 10.1006/jmbi.2000.3684. (10.1006/jmbi.2000.3684) / J Mol Biol by MA Andrade (2000)
  38. Persichetti F, Trettel F, Huang CC, Fraefel C, Timmers HT, Gusella JF, MacDonald ME: Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment. Neurobiol Dis. 1999, 6: 364-375. 10.1006/nbdi.1999.0260. (10.1006/nbdi.1999.0260) / Neurobiol Dis by F Persichetti (1999)
  39. Wheeler VC, Gutekunst CA, Vrbanac V, Lebel LA, Schilling G, Hersch S, Friedlander RM, Gusella JF, Vonsattel JP, Borchelt DR, et al: Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice. Hum Mol Genet. 2002, 11: 633-640. 10.1093/hmg/11.6.633. (10.1093/hmg/11.6.633) / Hum Mol Genet by VC Wheeler (2002)
  40. Govind S, Drier E, Huang LH, Steward R: Regulated nuclear import of the Drosophila rel protein dorsal: structure-function analysis. Mol Cell Biol. 1996, 16: 1103-1114. (10.1128/MCB.16.3.1103) / Mol Cell Biol by S Govind (1996)
  41. Drier EA, Steward R: The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila. Semin Cancer Biol. 1997, 8: 83-92. 10.1006/scbi.1997.0059. (10.1006/scbi.1997.0059) / Semin Cancer Biol by EA Drier (1997)
  42. Drier EA, Huang LH, Steward R: Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev. 1999, 13: 556-568. (10.1101/gad.13.5.556) / Genes Dev by EA Drier (1999)
  43. Drier EA, Govind S, Steward R: Cactus-independent regulation of Dorsal nuclear import by the ventral signal. Curr Biol. 2000, 10: 23-26. 10.1016/S0960-9822(99)00267-5. (10.1016/S0960-9822(99)00267-5) / Curr Biol by EA Drier (2000)
  44. Lunkes A, Lindenberg KS, Ben-Haiem L, Weber C, Devys D, Landwehrmeyer GB, Mandel JL, Trottier Y: Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions. Mol Cell. 2002, 10: 259-269. 10.1016/S1097-2765(02)00602-0. (10.1016/S1097-2765(02)00602-0) / Mol Cell by A Lunkes (2002)
  45. Goffredo D, Rigamonti D, Tartari M, De Micheli A, Verderio C, Matteoli M, Zuccato C, Cattaneo E: Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons. J Biol Chem. 2002. / J Biol Chem by D Goffredo (2002)
  46. Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin N, DiFiglia M: Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc Natl Acad Sci U S A. 2001, 98: 12784-9. 10.1073/pnas.221451398. (10.1073/pnas.221451398) / Proc Natl Acad Sci U S A by YJ Kim (2001)
  47. Wellington CL, Leavitt BR, Hayden MR: Huntington disease: new insights on the role of huntingtin cleavage. J Neural Transm Suppl. 2000, 1-17. / J Neural Transm Suppl by CL Wellington (2000)
  48. Rigamonti D, Bauer JH, De-Fraja C, Conti L, Sipione S, Sciorati C, Clementi E, Hackam A, Hayden MR, Li Y, et al: Wild-type huntingtin protects from apoptosis upstream of caspase-3. J Neurosci. 2000, 20: 3705-3713. (10.1523/JNEUROSCI.20-10-03705.2000) / J Neurosci by D Rigamonti (2000)
  49. Shiga Y, Tanaka-Makatsu M, Hayashi S: A nuclear GFP/beta-galactosidase fusion protein as a marker for morphogenesis in living Drosophila. Dev Growth Diff. 1996, 38: 99-106. 10.1046/j.1440-169X.1996.00012.x. (10.1046/j.1440-169X.1996.00012.x) / Dev Growth Diff by Y Shiga (1996)
Dates
Type When
Created 22 years, 9 months ago (Nov. 26, 2002, 7:08 a.m.)
Deposited 11 months, 3 weeks ago (Sept. 13, 2024, 11:36 a.m.)
Indexed 3 days, 4 hours ago (Sept. 3, 2025, 6:40 a.m.)
Issued 22 years, 10 months ago (Oct. 14, 2002)
Published 22 years, 10 months ago (Oct. 14, 2002)
Published Online 22 years, 10 months ago (Oct. 14, 2002)
Funders 0

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@article{Takano_2002, title={The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor}, volume={3}, ISSN={1471-2202}, url={http://dx.doi.org/10.1186/1471-2202-3-15}, DOI={10.1186/1471-2202-3-15}, number={1}, journal={BMC Neuroscience}, publisher={Springer Science and Business Media LLC}, author={Takano, Hiroki and Gusella, James F}, year={2002}, month=oct }