DOI: 10.1183/09031936.06.00087905. Alveolar nitric oxide<i>versus</i>measures of peripheral airway dysfunction in severe asthma

Alveolar nitric oxideversusmeasures of peripheral airway dysfunction in severe asthma

10.1183/09031936.06.00087905

Crossref journal-article

European Respiratory Society (ERS)

European Respiratory Journal (81)

Abstract

Alveolar nitric oxide (NO) is a measure of peripheral airway inflammation in asthma, potentially associated with disease severity. The relationship between alveolar NO and physiological tests of peripheral airway (dys)function has not been investigated. The present authors hypothesised that peripheral airway inflammation and dysfunction are inter-related and associated with asthma severity.Alveolar NO was compared between 17 patients with mild-to-moderate asthma and 14 patients with severe asthma and related to total lung capacity (TLC), residual volume (RV)/TLC, thoracic gas volume (FRC), slope of the single breath nitrogen washout curve (dN2), closing capacity (CC)/TLC and fall in forced vital capacity at the provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second. In patients with severe asthma, strong correlations were found between alveolar NO and RV/TLC % pred, FRC % pred, dN2, and CC/TLC. Patients with oral steroid-dependent asthma had higher alveolar NO levels (2.7 ppb) compared with the other patients with severe (0.6 ppb) and mild-to-moderate asthma (0.3 ppb).The present authors conclude that alveolar nitric oxide is closely related to parameters of peripheral airway dysfunction in patients with severe asthma, and that oral steroid-dependent asthmatics have more peripheral airway disease than nonsteroid-dependent asthmatics. This suggests that patients on chronic oral steroid treatment have more extensive disease and require additional anti-inflammatory treatment to better target the peripheral airways.

Bibliography

van Veen, I. H., Sterk, P. J., Schot, R., Gauw, S. A., Rabe, K. F., & Bel, E. H. (2006). Alveolar nitric oxideversusmeasures of peripheral airway dysfunction in severe asthma. European Respiratory Journal, 27(5), 951â956.

Authors 6

I. H. van Veen (first)
P. J. Sterk (additional)
R. Schot (additional)
S. A. Gauw (additional)
K. F. Rabe (additional)
E. H. Bel (additional)

References 29 Referenced 112

Dates

Type	When
Created	19 years, 6 months ago (Jan. 30, 2006, 8:33 p.m.)
Deposited	6 months ago (Feb. 24, 2025, 12:54 a.m.)
Indexed	42 minutes ago (Aug. 30, 2025, 11:53 a.m.)
Issued	19 years, 7 months ago (Jan. 30, 2006)
Published	19 years, 7 months ago (Jan. 30, 2006)
Published Online	19 years, 7 months ago (Jan. 30, 2006)
Published Print	19 years, 3 months ago (May 1, 2006)

Funders 0

None

BibTeX

@article{van_Veen_2006, title={Alveolar nitric oxideversusmeasures of peripheral airway dysfunction in severe asthma}, volume={27}, ISSN={1399-3003}, url={http://dx.doi.org/10.1183/09031936.06.00087905}, DOI={10.1183/09031936.06.00087905}, number={5}, journal={European Respiratory Journal}, publisher={European Respiratory Society (ERS)}, author={van Veen, I. H. and Sterk, P. J. and Schot, R. and Gauw, S. A. and Rabe, K. F. and Bel, E. H.}, year={2006}, month=jan, pages={951–956} }

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