DOI: 10.1183/09031936.03.00061703. The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease

The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease

10.1183/09031936.03.00061703

Crossref journal-article

European Respiratory Society (ERS)

European Respiratory Journal (81)

Abstract

Toll-like receptor 2 (TLR2), a member of the Toll-like receptor family, plays an important role in recognition of, and subsequent immune response activation against, mycobacteria. The genetic polymorphism of TLR2 (arginine to glutamine substitution at residue 753 (Arg753Gln)) has been associated with a negative influence on TLR2 function, which may, in turn, determine the innate host response to mycobacteria. The aim of the present study was to investigate the Arg753Gln single nucleotide polymorphism of the TLR2 gene in tuberculosis (TB) patients compared to healthy controls.A retrospective case/control study was carried out. The Arg753Gln polymorphism of the TLR2 gene was studied in 151 TB patients compared to 116 ethnically and age-matched healthy control subjects.The TLR2 polymorphism (adenine (A) allele) was observed in 17.9 and 7.7% of TB patients and controls, respectively. When the ratios of the three genotypes were compared between the two groups, the AA genotype was found to be more significantly associated with TB. Allele frequencies for guanine (G) and A were found to be 0.95 and 0.05 in the control group and 0.86 and 0.14 in the TB patient group, respectively. The risk of developing TB disease was increased 6.04‐ and 1.60‐fold for carriers of the AA and GA genotypes, respectively.In conclusion, the present data suggest that the arginine to glutamine substitution at residue 753 polymorphism of the Toll-like receptor 2 gene influences the risk of developing tuberculosis.

Bibliography

Ogus, A. C., Yoldas, B., Ozdemir, T., Uguz, A., Olcen, S., Keser, I., Coskun, M., Cilli, A., & Yegin, O. (2004). The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease. European Respiratory Journal, 23(2), 219â223.

Authors 9

A.C. Ogus (first)
B. Yoldas (additional)
T. Ozdemir (additional)
A. Uguz (additional)
S. Olcen (additional)
I. Keser (additional)
M. Coskun (additional)
A. Cilli (additional)
O. Yegin (additional)

References 32 Referenced 310

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Fraser RS, Muller NL, Colman N, Pare PD, editors. Mycobacteria In:. Fraser and Pare's Diagnosis of Diseases of the Chest. 4th EdnPhiladelphia, PA, USA, W.B. Saunders Company, 1999; pp. 798–873.
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Dates

Type	When
Created	21 years, 7 months ago (Feb. 4, 2004, 6:44 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 24, 2025, 1:19 a.m.)
Indexed	1 week, 2 days ago (Aug. 29, 2025, 5:58 a.m.)
Issued	21 years, 7 months ago (Feb. 1, 2004)
Published	21 years, 7 months ago (Feb. 1, 2004)
Published Online	21 years, 7 months ago (Feb. 1, 2004)
Published Print	21 years, 7 months ago (Feb. 1, 2004)

Funders 0

None

BibTeX

@article{Ogus_2004, title={The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease}, volume={23}, ISSN={1399-3003}, url={http://dx.doi.org/10.1183/09031936.03.00061703}, DOI={10.1183/09031936.03.00061703}, number={2}, journal={European Respiratory Journal}, publisher={European Respiratory Society (ERS)}, author={Ogus, A.C. and Yoldas, B. and Ozdemir, T. and Uguz, A. and Olcen, S. and Keser, I. and Coskun, M. and Cilli, A. and Yegin, O.}, year={2004}, month=feb, pages={219–223} }

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  "abstract": "<jats:p>Toll-like receptor 2 (TLR2), a member of the Toll-like receptor family, plays an important role in recognition of, and subsequent immune response activation against, mycobacteria. The genetic polymorphism of TLR2 (arginine to glutamine substitution at residue 753 (Arg753Gln)) has been associated with a negative influence on TLR2 function, which may, in turn, determine the innate host response to mycobacteria. The aim of the present study was to investigate the Arg753Gln single nucleotide polymorphism of the TLR2 gene in tuberculosis (TB) patients compared to healthy controls.</jats:p><jats:p>A retrospective case/control study was carried out. The Arg753Gln polymorphism of the TLR2 gene was studied in 151 TB patients compared to 116 ethnically and age-matched healthy control subjects.</jats:p><jats:p>The TLR2 polymorphism (adenine (A) allele) was observed in 17.9 and 7.7% of TB patients and controls, respectively. When the ratios of the three genotypes were compared between the two groups, the AA genotype was found to be more significantly associated with TB. Allele frequencies for guanine (G) and A were found to be 0.95 and 0.05 in the control group and 0.86 and 0.14 in the TB patient group, respectively. The risk of developing TB disease was increased 6.04\u2010 and 1.60\u2010fold for carriers of the AA and GA genotypes, respectively.</jats:p><jats:p>In conclusion, the present data suggest that the arginine to glutamine substitution at residue 753 polymorphism of the Toll-like receptor 2 gene influences the risk of developing tuberculosis.</jats:p>",
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