Type I interferons produced by dendritic cells promote their phenotypic and functional activation
10.1182/blood.v99.9.3263
Crossref journal-article
American Society of Hematology
Blood (234)
Abstract

AbstractResting dendritic cells (DCs) are resident in most tissues and can be activated by environmental stimuli to mature into potent antigen-presenting cells. One important stimulus for DC activation is infection; DCs can be triggered through receptors that recognize microbial components directly or by contact with infection-induced cytokines. We show here that murine DCs undergo phenotypic maturation upon exposure to type I interferons (type I IFNs) in vivo or in vitro. Moreover, DCs either derived from bone marrow cells in vitro or isolated from the spleens of normal animals express IFN-α and IFN-β, suggesting that type I IFNs can act in an autocrine manner to activate DCs. Consistent with this idea, the ability to respond to type I IFN was required for the generation of fully activated DCs from bone marrow precursors, as DCs derived from the bone marrow of mice lacking a functional receptor for type I IFN had reduced expression of costimulatory and adhesion molecules and a diminished ability to stimulate naive T-cell proliferation compared with DCs derived from control bone marrow. Furthermore, the addition of neutralizing anti–IFN-α/β antibody to purified splenic DCs in vitro partially blocked the “spontaneous” activation of these cells, inhibiting the up-regulation of costimulatory molecules, secretion of IFN-γ, and T-cell stimulatory activity. These results show that DCs both secrete and respond to type I IFN, identifying type I interferons as autocrine DC activators.

Bibliography

Montoya, M., Schiavoni, G., Mattei, F., Gresser, I., Belardelli, F., Borrow, P., & Tough, D. F. (2002). Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood, 99(9), 3263–3271.

Authors 7
  1. Maria Montoya (first)
  2. Giovanna Schiavoni (additional)
  3. Fabrizio Mattei (additional)
  4. Ion Gresser (additional)
  5. Filippo Belardelli (additional)
  6. Persephone Borrow (additional)
  7. David F. Tough (additional)
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Dates
Type When
Created 22 years, 10 months ago (Oct. 11, 2002, 2:33 p.m.)
Deposited 2 years, 4 months ago (April 24, 2023, 4:22 a.m.)
Indexed 2 days, 13 hours ago (Aug. 30, 2025, 1:19 p.m.)
Issued 23 years, 4 months ago (May 1, 2002)
Published 23 years, 4 months ago (May 1, 2002)
Published Print 23 years, 4 months ago (May 1, 2002)
Funders 0

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@article{Montoya_2002, title={Type I interferons produced by dendritic cells promote their phenotypic and functional activation}, volume={99}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood.v99.9.3263}, DOI={10.1182/blood.v99.9.3263}, number={9}, journal={Blood}, publisher={American Society of Hematology}, author={Montoya, Maria and Schiavoni, Giovanna and Mattei, Fabrizio and Gresser, Ion and Belardelli, Filippo and Borrow, Persephone and Tough, David F.}, year={2002}, month=may, pages={3263–3271} }