DOI: 10.1182/blood.v97.7.1990. Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF β-receptor null mice

Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF β-receptor null mice

10.1182/blood.v97.7.1990

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

AbstractPlatelet-derived growth factor (PDGF)-B and PDGF β-receptor (PDGFRβ) deficiency in mice is embryonic lethal and results in cardiovascular, renal, placental, and hematologic disorders. The hematologic disorders are described, and a correlation with hepatic hypocellularity is demonstrated. To explore possible causes, the colony-forming activity of fetal liver cells in vitro was assessed, and hematopoietic chimeras were demonstrated by the transplantation of mutant fetal liver cells into lethally irradiated recipients. It was found that mutant colony formation is equivalent to that of wild-type controls. Hematopoietic chimeras reconstituted with PDGF-B−/−, PDGFRβ−/−, or wild-type fetal liver cells show complete engraftment (greater than 98%) with donor granulocytes, monocytes, B cells, and T cells and display none of the cardiovascular or hematologic abnormalities seen in mutants. In mouse embryos, PDGF-B is expressed by vascular endothelial cells and megakaryocytes. After birth, expression is seen in macrophages and neurons. This study demonstrates that hematopoietic PDGF-B or PDGFRβ expression is not required for hematopoiesis or integrity of the cardiovascular system. It is argued that metabolic stress arising from mutant defects in the placenta, heart, or blood vessels may lead to impaired liver growth and decreased production of blood cells. The chimera models in this study will serve as valuable tools to test the role of PDGF in inflammatory and immune responses.

Bibliography

Kaminski, W. E., Lindahl, P., Lin, N. L., Broudy, V. C., Crosby, J. R., HellstroÌm, M., Swolin, B., Bowen-Pope, D. F., Martin, P. J., Ross, R., Betsholtz, C., & Raines, E. W. (2001). Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF Î²-receptor null mice. Blood, 97(7), 1990â1998.

Authors 12

Wolfgang E. Kaminski (first)
Per Lindahl (additional)
Nancy L. Lin (additional)
Virginia C. Broudy (additional)
Jeffrey R. Crosby (additional)
Mats Hellström (additional)
Birgitta Swolin (additional)
Daniel F. Bowen-Pope (additional)
Paul J. Martin (additional)
Russell Ross (additional)
Christer Betsholtz (additional)
Elaine W. Raines (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 8:46 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 4:10 p.m.)
Indexed	2 months, 2 weeks ago (June 17, 2025, 8 p.m.)
Issued	24 years, 5 months ago (April 1, 2001)
Published	24 years, 5 months ago (April 1, 2001)
Published Print	24 years, 5 months ago (April 1, 2001)

Funders 0

None

BibTeX

@article{Kaminski_2001, title={Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF β-receptor null mice}, volume={97}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood.v97.7.1990}, DOI={10.1182/blood.v97.7.1990}, number={7}, journal={Blood}, publisher={American Society of Hematology}, author={Kaminski, Wolfgang E. and Lindahl, Per and Lin, Nancy L. and Broudy, Virginia C. and Crosby, Jeffrey R. and Hellström, Mats and Swolin, Birgitta and Bowen-Pope, Daniel F. and Martin, Paul J. and Ross, Russell and Betsholtz, Christer and Raines, Elaine W.}, year={2001}, month=apr, pages={1990–1998} }

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  }
}