DOI: 10.1182/blood.v97.6.1727. Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen

Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen

10.1182/blood.v97.6.1727

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Platelet responses to collagen are mediated by the combined actions of the integrin α2β1, which serves as a major collagen-binding receptor, and the GPVI/FcRγ-chain complex, which transmits collagen-specific activation signals into the cell interior through the action of an immunoreceptor tyrosine-based activation motif within the cytoplasmic domain of the FcRγ-chain. Despite much progress in identifying components of the signaling pathway responsible for collagen-induced platelet activation, virtually nothing is known about the regulatory elements that modulate this important hemostatic event. PECAM-1, a recently recognized member of the inhibitory receptor family, contains a functional immunoreceptor tyrosine-based inhibitory motif within its cytoplasmic domain that, when tyrosine phosphorylated, recruits and activates the protein–tyrosine phosphatase, SHP-2. To test the hypothesis that PECAM-1 functions to regulate GPVI/FcRγ-chain–mediated platelet activation, the responses of wild-type versus PECAM-1–deficient murine platelets to GPVI-specific agonists were compared. Four distinct GPVI/FcRγ-chain–dependent responses were found to be significantly exaggerated in platelets derived from PECAM-1–deficient mice, including Mg++-independent adhesion to immobilized fibrillar collagen, collagen-induced platelet aggregation, platelet aggregation induced by the GPVI-specific agonist collagen-related peptide, and GPVI/FcRγ-chain–induced dense granule secretion. Together, these data provide compelling evidence that PECAM-1 modulates platelet responses to collagen, and they implicate this novel member of the inhibitory receptor family in the regulation of primary hemostasis.

Bibliography

Patil, S., Newman, D. K., & Newman, P. J. (2001). Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen. Blood, 97(6), 1727â1732.

Authors 3

Sonali Patil (first)
Debra K. Newman (additional)
Peter J. Newman (additional)

References 68 Referenced 122

10.1126/science.1690453 / Science. / PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. by Newman (1990)
10.1074/jbc.271.31.18561 / J Biol Chem. / Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression. by Sun (1996)
10.1074/jbc.271.19.11090 / J Biol Chem. / Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity. by Sun (1996)
10.1084/jem.179.3.1059 / J Exp Med. / Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo. by Bogen (1994)
10.1084/jem.178.2.449 / J Exp Med. / PECAM-1 is required for transendothelial migration of leukocytes. by Muller (1993)
10.1126/science.8248808 / Science. / Involvement of platelet endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. by Vaporciyan (1993)
10.1023/A:1009092107382 / Angiogenesis. / Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice. by Zhou (1999)
10.1038/nm1297-1405 / Nat Med. / PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparuminfected erythrocytes. by Treutiger (1997)
10.1084/jem.192.1.1 / J Exp Med. / The semiconserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors. by Chen (2000)
10.1172/JCI5928 / J Clin Invest. / Switched at birth: a new family for PECAM-1. by Newman (1999)
10.1074/jbc.272.40.24868 / J Biol Chem. / Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2. by Jackson (1997)
10.1074/jbc.272.11.6986 / J Biol Chem. / The protein-tyrosine phosphatase SHP-2 binds PECAM-1 and forms a distinct signaling complex during platelet aggregation: evidence for a mechanistic link between PECAM-1 and integrin-mediated cellular signaling. by Jackson (1997)
10.1074/jbc.272.49.31086 / J Biol Chem. / The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31). by Sagawa (1997)
10.1016/S0014-5793(97)00457-2 / FEBS Lett. / Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells. by Masuda (1997)
10.1073/pnas.94.12.5993 / Proc Natl Acad Sci U S A. / Inhibitory receptors abound? by Cambier (1997)
10.4049/jimmunol.159.5.2075 / J Immunol. / Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts. by Vely (1997)
10.1038/338383b0 / Nature. / Antigen receptor tail clue [letter]. by Reth (1989)
10.1016/S0952-7915(97)80168-9 / Curr Opin Immunol. / Fc receptors. by Ravetch (1997)
10.1016/S0167-5699(98)01267-5 / Immunol Today. / Collagen receptor signalling in platelets: extending the role of the ITAM. by Watson (1998)
10.4049/jimmunol.163.2.682 / J Immunol. / A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction. by Newton-Nash (1999)
10.4049/jimmunol.162.5.3022 / J Immunol. / Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1): CD31 deficient mice reveal PECAM-1 dependent and PECAM-1 independent functions. by Duncan (1999)
10.1042/bj3060337 / Biochem J. / Integrin α2β1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple helical) and quaternary (polymeric) structures are sufficient alone for α2β1-independent platelet reactivity. by Morton (1995)
10.1016/S0014-5793(97)00926-5 / FEBS Lett. / Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain. by Gibbins (1997)
10.1182/blood.V89.4.1235 / Blood. / A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase Cγ2 in platelets independent of integrin α2β1. by Asselin (1997)
10.1074/jbc.273.51.34437 / J Biol Chem. / The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activator of T cells (LAT) in platelets stimulated by collagen and convulxin. by Gibbins (1998)
10.1074/jbc.274.9.5963 / J Biol Chem. / Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. by Gross (1999)
10.1006/bbrc.1999.0295 / Biochem Biophys Res Commun. / Signal transduction pathways mediated by glycoprotein Ia/IIa in human platelets: comparison with those of glycoprotein VI. by Inoue (1999)
10.1182/blood.V93.11.3847 / Blood. / Collagen mediates changes in intracellular calcium in primary mouse megakaryocytes through syk-dependent and -independent pathways. by Briddon (1999)
10.1128/MCB.19.12.8326 / Mol Cell Biol. / LAT is required for tyrosine phosphorylation of phospholipase Cγ2 and platelet activation by the collagen receptor GPVI. by Pasquet (1999)
{'key': '2020021221030115200_B30', 'first-page': '1663', 'article-title': "Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking.", 'volume': '95', 'author': 'Oda', 'year': '2000', 'journal-title': 'Blood.'} / Blood. / Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking. by Oda (2000)
{'key': '2020021221030115200_B31', 'first-page': '29a', 'article-title': 'PECAM-1-mediated signal transduction can be initiated by cell adhesion to extracellular matrix [abstract].', 'volume': '92', 'author': 'Wang', 'year': '1998', 'journal-title': 'Blood.'} / Blood. / PECAM-1-mediated signal transduction can be initiated by cell adhesion to extracellular matrix [abstract]. by Wang (1998)
10.1016/S0021-9258(19)61516-4 / J Biol Chem. / Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of cd31 in platelets: evidence for the involvement of Src family kinases. by Cicmil (2000)
10.1074/jbc.273.8.4338 / J Biol Chem. / Platelet adhesion to native type I collagen fibrils: role of GPVI in divalent cation-dependent and -independent adhesion and thromboxane A2 generation. by Nakamura (1998)
10.1016/S0952-7915(97)80088-X / Curr Opin Immunol. / Role of phosphatases in lymphocyte activation. by Neel (1997)
10.1016/0092-8674(91)90261-V / Cell. / Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. by Vu (1991)
10.1016/S0167-5699(98)01267-5 / Immunol Today. / Collagen receptor signaling in platelets: extending the role of the ITAM. by Watson (1998)
10.1016/0092-8674(86)90073-5 / Cell. / Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen. by Santoro (1986)
10.1016/S0021-9258(18)68811-8 / J Biol Chem. / The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex. by Kunicki (1988)
10.1182/blood.V74.1.182.182 / Blood. / Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins. by Coller (1989)
10.1038/318470a0 / Nature. / Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia. by Nieuwenhuis (1985)
10.1182/blood.V71.4.1074.1074 / Blood. / Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder. by Kehrel (1988)
10.1172/JCI114318 / J Clin Invest. / A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. by Moroi (1989)
10.1074/jbc.272.38.23528 / J Biol Chem. / A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. by Tsuji (1997)
10.1084/jem.188.2.267 / J Exp Med. / Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets. by Ezumi (1998)
10.1042/bj3380203 / Biochem J. / Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets. by Briddon (1999)
10.1074/jbc.271.30.18095 / J Biol Chem. / Tyrosine phosphorylation of the Fc receptor γ-chain in collagen-stimulated platelets. by Gibbins (1996)
10.1074/jbc.272.44.27539 / J Biol Chem. / Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide. by Melford (1997)
10.1074/jbc.272.21.13576 / J Biol Chem. / Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. by Polgar (1997)
10.1074/jbc.273.43.28332 / J Biol Chem. / Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). by Hua (1998)
10.1074/jbc.273.25.15765 / J Biol Chem. / Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. by Cao (1998)
10.1016/S0014-5793(99)00446-9 / FEBS Lett. / Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase Cγ1 with PECAM-1/CD31. by Pumphrey (1999)
10.1016/S0955-0674(97)80063-4 / Curr Opin Cell Biol. / Protein tyrosine phosphatases in signal transduction. by Neel (1997)
10.1016/S1357-2725(98)00002-8 / Int J Biochem Cell Biol. / SHP-2, SH2-containing protein tyrosine phosphatase-2. by Stein-Gerlach (1998)
10.1006/excr.1999.4668 / Exp Cell Res. / SHP-2 tyrosine phosphatase: signaling one cell or many. by Feng (1999)
10.1074/jbc.272.34.21113 / J Biol Chem. / Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase. by Somani (1997)
10.1002/(SICI)1521-4141(199908)29:08<2539::AID-IMMU2539>3.0.CO;2-M / Eur J Immunol. / Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP-1. by Brockdorff (1999)
10.1016/S0960-9822(06)00298-3 / Curr Biol. / The protein tyrosin phosphatase SHP-2 negatively regulates ciliary neurotrophic induction of gene expression. by Symes (1997)
10.1074/jbc.273.9.4904 / J Biol Chem. / The SHP-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. by Shi (1998)
10.1128/MCB.19.3.2416 / Mol Cell Biol. / Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. by You (1999)
10.1074/jbc.M001531200 / J Biol Chem. / Evidence for a role of SHP-1 in platelet activation by the collagen receptor GPVI. by Pasquet (2000)
10.1006/bbrc.1996.0139 / Biochem Biophys Res Commun. / Cloning and chromosomal localization of the human P2Y1 purinoceptor 35. by Ayyanathan (1996)
10.1074/jbc.273.4.2024 / J Biol Chem. / Molecular basis for ADPinduced platelet activation, I: evidence for three distinct ADP receptors on human platelets. by Daniel (1998)
10.1016/S0002-9440(10)64519-1 / Am J Pathol. / PECAM-1 (CD31) expression modulates bleeding time in vivo. by Mahooti (2000)
10.1074/jbc.270.13.7029 / J Biol Chem. / Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. by Jackman (1995)
10.1074/jbc.274.9.5963 / J Biol Chem. / Tyrosine phosphorylation of SLP-76 is downstream of syk following stimulation of the collagen receptor in platelets. by Gross (1999)
10.1172/JCI5317 / J Clin Invest. / Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice. by Clements (1999)
10.1016/S0092-8674(00)80901-0 / Cell. / LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. by Zhang (1998)
10.1128/MCB.19.12.8326 / Mol Cell Biol. / LAT is required for tyrosine phosphorylation of phospholipase Cγ2 and platelet activation by the collagen receptor GPVI. by Pasquet (1999)

Dates

Type	When
Created	23 years ago (July 27, 2002, 8:46 a.m.)
Deposited	1 year, 7 months ago (Jan. 6, 2024, 1:43 a.m.)
Indexed	2 months, 2 weeks ago (June 10, 2025, 3:04 p.m.)
Issued	24 years, 5 months ago (March 15, 2001)
Published	24 years, 5 months ago (March 15, 2001)
Published Print	24 years, 5 months ago (March 15, 2001)

Funders 0

None

BibTeX

@article{Patil_2001, title={Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen}, volume={97}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood.v97.6.1727}, DOI={10.1182/blood.v97.6.1727}, number={6}, journal={Blood}, publisher={American Society of Hematology}, author={Patil, Sonali and Newman, Debra K. and Newman, Peter J.}, year={2001}, month=mar, pages={1727–1732} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        10
      ]
    ],
    "date-time": "2025-06-10T19:04:05Z",
    "timestamp": 1749582245855
  },
  "reference-count": 68,
  "publisher": "American Society of Hematology",
  "issue": "6",
  "content-domain": {
    "domain": [
      "ashpublications.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        3,
        15
      ]
    ]
  },
  "abstract": "<jats:p>Platelet responses to collagen are mediated by the combined actions of the integrin \u03b12\u03b21, which serves as a major collagen-binding receptor, and the GPVI/FcR\u03b3-chain complex, which transmits collagen-specific activation signals into the cell interior through the action of an immunoreceptor tyrosine-based activation motif within the cytoplasmic domain of the FcR\u03b3-chain. Despite much progress in identifying components of the signaling pathway responsible for collagen-induced platelet activation, virtually nothing is known about the regulatory elements that modulate this important hemostatic event. PECAM-1, a recently recognized member of the inhibitory receptor family, contains a functional immunoreceptor tyrosine-based inhibitory motif within its cytoplasmic domain that, when tyrosine phosphorylated, recruits and activates the protein\u2013tyrosine phosphatase, SHP-2. To test the hypothesis that PECAM-1 functions to regulate GPVI/FcR\u03b3-chain\u2013mediated platelet activation, the responses of wild-type versus PECAM-1\u2013deficient murine platelets to GPVI-specific agonists were compared. Four distinct GPVI/FcR\u03b3-chain\u2013dependent responses were found to be significantly exaggerated in platelets derived from PECAM-1\u2013deficient mice, including Mg++-independent adhesion to immobilized fibrillar collagen, collagen-induced platelet aggregation, platelet aggregation induced by the GPVI-specific agonist collagen-related peptide, and GPVI/FcR\u03b3-chain\u2013induced dense granule secretion. Together, these data provide compelling evidence that PECAM-1 modulates platelet responses to collagen, and they implicate this novel member of the inhibitory receptor family in the regulation of primary hemostasis.</jats:p>",
  "DOI": "10.1182/blood.v97.6.1727",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        27
      ]
    ],
    "date-time": "2002-07-27T12:46:47Z",
    "timestamp": 1027774007000
  },
  "page": "1727-1732",
  "update-policy": "http://dx.doi.org/10.1182/blood.2019cm0000",
  "source": "Crossref",
  "is-referenced-by-count": 122,
  "title": "Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen",
  "prefix": "10.1182",
  "volume": "97",
  "author": [
    {
      "given": "Sonali",
      "family": "Patil",
      "sequence": "first",
      "affiliation": [
        {
          "name": "From the Blood Research Institute, The Blood Center of Southeastern Wisconsin, and the Departments of Microbiology and Molecular Genetics, Pharmacology, and Cellular Biology, Medical College of Wisconsin, Milwaukee, WI."
        }
      ]
    },
    {
      "given": "Debra K.",
      "family": "Newman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "From the Blood Research Institute, The Blood Center of Southeastern Wisconsin, and the Departments of Microbiology and Molecular Genetics, Pharmacology, and Cellular Biology, Medical College of Wisconsin, Milwaukee, WI."
        }
      ]
    },
    {
      "given": "Peter J.",
      "family": "Newman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "From the Blood Research Institute, The Blood Center of Southeastern Wisconsin, and the Departments of Microbiology and Molecular Genetics, Pharmacology, and Cellular Biology, Medical College of Wisconsin, Milwaukee, WI."
        }
      ]
    }
  ],
  "member": "234",
  "reference": [
    {
      "key": "2020021221030115200_B1",
      "doi-asserted-by": "crossref",
      "first-page": "1219",
      "DOI": "10.1126/science.1690453",
      "article-title": "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.",
      "volume": "247",
      "author": "Newman",
      "year": "1990",
      "journal-title": "Science."
    },
    {
      "key": "2020021221030115200_B2",
      "doi-asserted-by": "crossref",
      "first-page": "18561",
      "DOI": "10.1074/jbc.271.31.18561",
      "article-title": "Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression.",
      "volume": "271",
      "author": "Sun",
      "year": "1996",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B3",
      "doi-asserted-by": "crossref",
      "first-page": "11090",
      "DOI": "10.1074/jbc.271.19.11090",
      "article-title": "Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity.",
      "volume": "271",
      "author": "Sun",
      "year": "1996",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B4",
      "doi-asserted-by": "crossref",
      "first-page": "1059",
      "DOI": "10.1084/jem.179.3.1059",
      "article-title": "Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.",
      "volume": "179",
      "author": "Bogen",
      "year": "1994",
      "journal-title": "J Exp Med."
    },
    {
      "key": "2020021221030115200_B5",
      "doi-asserted-by": "crossref",
      "first-page": "449",
      "DOI": "10.1084/jem.178.2.449",
      "article-title": "PECAM-1 is required for transendothelial migration of leukocytes.",
      "volume": "178",
      "author": "Muller",
      "year": "1993",
      "journal-title": "J Exp Med."
    },
    {
      "key": "2020021221030115200_B6",
      "doi-asserted-by": "crossref",
      "first-page": "1580",
      "DOI": "10.1126/science.8248808",
      "article-title": "Involvement of platelet endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo.",
      "volume": "262",
      "author": "Vaporciyan",
      "year": "1993",
      "journal-title": "Science."
    },
    {
      "key": "2020021221030115200_B7",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1023/A:1009092107382",
      "article-title": "Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice.",
      "volume": "3",
      "author": "Zhou",
      "year": "1999",
      "journal-title": "Angiogenesis."
    },
    {
      "key": "2020021221030115200_B8",
      "doi-asserted-by": "crossref",
      "first-page": "1405",
      "DOI": "10.1038/nm1297-1405",
      "article-title": "PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparuminfected erythrocytes.",
      "volume": "3",
      "author": "Treutiger",
      "year": "1997",
      "journal-title": "Nat Med."
    },
    {
      "key": "2020021221030115200_B9",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1084/jem.192.1.1",
      "article-title": "The semiconserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors.",
      "volume": "192",
      "author": "Chen",
      "year": "2000",
      "journal-title": "J Exp Med."
    },
    {
      "key": "2020021221030115200_B10",
      "doi-asserted-by": "crossref",
      "first-page": "5",
      "DOI": "10.1172/JCI5928",
      "article-title": "Switched at birth: a new family for PECAM-1.",
      "volume": "103",
      "author": "Newman",
      "year": "1999",
      "journal-title": "J Clin Invest."
    },
    {
      "key": "2020021221030115200_B11",
      "doi-asserted-by": "crossref",
      "first-page": "24868",
      "DOI": "10.1074/jbc.272.40.24868",
      "article-title": "Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2.",
      "volume": "272",
      "author": "Jackson",
      "year": "1997",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B12",
      "doi-asserted-by": "crossref",
      "first-page": "6986",
      "DOI": "10.1074/jbc.272.11.6986",
      "article-title": "The protein-tyrosine phosphatase SHP-2 binds PECAM-1 and forms a distinct signaling complex during platelet aggregation: evidence for a mechanistic link between PECAM-1 and integrin-mediated cellular signaling.",
      "volume": "272",
      "author": "Jackson",
      "year": "1997",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B13",
      "doi-asserted-by": "crossref",
      "first-page": "31086",
      "DOI": "10.1074/jbc.272.49.31086",
      "article-title": "The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31).",
      "volume": "272",
      "author": "Sagawa",
      "year": "1997",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B14",
      "doi-asserted-by": "crossref",
      "first-page": "331",
      "DOI": "10.1016/S0014-5793(97)00457-2",
      "article-title": "Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells.",
      "volume": "408",
      "author": "Masuda",
      "year": "1997",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "2020021221030115200_B15",
      "doi-asserted-by": "crossref",
      "first-page": "5993",
      "DOI": "10.1073/pnas.94.12.5993",
      "article-title": "Inhibitory receptors abound?",
      "volume": "94",
      "author": "Cambier",
      "year": "1997",
      "journal-title": "Proc Natl Acad Sci U S A."
    },
    {
      "key": "2020021221030115200_B16",
      "doi-asserted-by": "crossref",
      "first-page": "2075",
      "DOI": "10.4049/jimmunol.159.5.2075",
      "article-title": "Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts.",
      "volume": "159",
      "author": "Vely",
      "year": "1997",
      "journal-title": "J Immunol."
    },
    {
      "key": "2020021221030115200_B17",
      "doi-asserted-by": "crossref",
      "first-page": "383",
      "DOI": "10.1038/338383b0",
      "article-title": "Antigen receptor tail clue [letter].",
      "volume": "338",
      "author": "Reth",
      "year": "1989",
      "journal-title": "Nature."
    },
    {
      "key": "2020021221030115200_B18",
      "doi-asserted-by": "crossref",
      "first-page": "121",
      "DOI": "10.1016/S0952-7915(97)80168-9",
      "article-title": "Fc receptors.",
      "volume": "9",
      "author": "Ravetch",
      "year": "1997",
      "journal-title": "Curr Opin Immunol."
    },
    {
      "key": "2020021221030115200_B19",
      "doi-asserted-by": "crossref",
      "first-page": "260",
      "DOI": "10.1016/S0167-5699(98)01267-5",
      "article-title": "Collagen receptor signalling in platelets: extending the role of the ITAM.",
      "volume": "19",
      "author": "Watson",
      "year": "1998",
      "journal-title": "Immunol Today."
    },
    {
      "key": "2020021221030115200_B20",
      "doi-asserted-by": "crossref",
      "first-page": "682",
      "DOI": "10.4049/jimmunol.163.2.682",
      "article-title": "A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction.",
      "volume": "163",
      "author": "Newton-Nash",
      "year": "1999",
      "journal-title": "J Immunol."
    },
    {
      "key": "2020021221030115200_B21",
      "doi-asserted-by": "crossref",
      "first-page": "3022",
      "DOI": "10.4049/jimmunol.162.5.3022",
      "article-title": "Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1): CD31 deficient mice reveal PECAM-1 dependent and PECAM-1 independent functions.",
      "volume": "162",
      "author": "Duncan",
      "year": "1999",
      "journal-title": "J Immunol."
    },
    {
      "key": "2020021221030115200_B22",
      "doi-asserted-by": "crossref",
      "first-page": "337",
      "DOI": "10.1042/bj3060337",
      "article-title": "Integrin \u03b12\u03b21-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple helical) and quaternary (polymeric) structures are sufficient alone for \u03b12\u03b21-independent platelet reactivity.",
      "volume": "306",
      "author": "Morton",
      "year": "1995",
      "journal-title": "Biochem J."
    },
    {
      "key": "2020021221030115200_B23",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1016/S0014-5793(97)00926-5",
      "article-title": "Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain.",
      "volume": "413",
      "author": "Gibbins",
      "year": "1997",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "2020021221030115200_B24",
      "doi-asserted-by": "crossref",
      "first-page": "1235",
      "DOI": "10.1182/blood.V89.4.1235",
      "article-title": "A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C\u03b32 in platelets independent of integrin \u03b12\u03b21.",
      "volume": "89",
      "author": "Asselin",
      "year": "1997",
      "journal-title": "Blood."
    },
    {
      "key": "2020021221030115200_B25",
      "doi-asserted-by": "crossref",
      "first-page": "34437",
      "DOI": "10.1074/jbc.273.51.34437",
      "article-title": "The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activator of T cells (LAT) in platelets stimulated by collagen and convulxin.",
      "volume": "273",
      "author": "Gibbins",
      "year": "1998",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B26",
      "doi-asserted-by": "crossref",
      "first-page": "5963",
      "DOI": "10.1074/jbc.274.9.5963",
      "article-title": "Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets.",
      "volume": "274",
      "author": "Gross",
      "year": "1999",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B27",
      "doi-asserted-by": "crossref",
      "first-page": "114",
      "DOI": "10.1006/bbrc.1999.0295",
      "article-title": "Signal transduction pathways mediated by glycoprotein Ia/IIa in human platelets: comparison with those of glycoprotein VI.",
      "volume": "256",
      "author": "Inoue",
      "year": "1999",
      "journal-title": "Biochem Biophys Res Commun."
    },
    {
      "key": "2020021221030115200_B28",
      "doi-asserted-by": "crossref",
      "first-page": "3847",
      "DOI": "10.1182/blood.V93.11.3847",
      "article-title": "Collagen mediates changes in intracellular calcium in primary mouse megakaryocytes through syk-dependent and -independent pathways.",
      "volume": "93",
      "author": "Briddon",
      "year": "1999",
      "journal-title": "Blood."
    },
    {
      "key": "2020021221030115200_B29",
      "doi-asserted-by": "crossref",
      "first-page": "8326",
      "DOI": "10.1128/MCB.19.12.8326",
      "article-title": "LAT is required for tyrosine phosphorylation of phospholipase C\u03b32 and platelet activation by the collagen receptor GPVI.",
      "volume": "19",
      "author": "Pasquet",
      "year": "1999",
      "journal-title": "Mol Cell Biol."
    },
    {
      "key": "2020021221030115200_B30",
      "first-page": "1663",
      "article-title": "Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking.",
      "volume": "95",
      "author": "Oda",
      "year": "2000",
      "journal-title": "Blood."
    },
    {
      "key": "2020021221030115200_B31",
      "first-page": "29a",
      "article-title": "PECAM-1-mediated signal transduction can be initiated by cell adhesion to extracellular matrix [abstract].",
      "volume": "92",
      "author": "Wang",
      "year": "1998",
      "journal-title": "Blood."
    },
    {
      "key": "2020021221030115200_B32",
      "doi-asserted-by": "crossref",
      "first-page": "27339",
      "DOI": "10.1016/S0021-9258(19)61516-4",
      "article-title": "Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of cd31 in platelets: evidence for the involvement of Src family kinases.",
      "volume": "275",
      "author": "Cicmil",
      "year": "2000",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B33",
      "doi-asserted-by": "crossref",
      "first-page": "4338",
      "DOI": "10.1074/jbc.273.8.4338",
      "article-title": "Platelet adhesion to native type I collagen fibrils: role of GPVI in divalent cation-dependent and -independent adhesion and thromboxane A2 generation.",
      "volume": "273",
      "author": "Nakamura",
      "year": "1998",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B34",
      "doi-asserted-by": "crossref",
      "first-page": "405",
      "DOI": "10.1016/S0952-7915(97)80088-X",
      "article-title": "Role of phosphatases in lymphocyte activation.",
      "volume": "9",
      "author": "Neel",
      "year": "1997",
      "journal-title": "Curr Opin Immunol."
    },
    {
      "key": "2020021221030115200_B35",
      "doi-asserted-by": "crossref",
      "first-page": "1057",
      "DOI": "10.1016/0092-8674(91)90261-V",
      "article-title": "Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.",
      "volume": "64",
      "author": "Vu",
      "year": "1991",
      "journal-title": "Cell."
    },
    {
      "key": "2020021221030115200_B36",
      "doi-asserted-by": "crossref",
      "first-page": "260",
      "DOI": "10.1016/S0167-5699(98)01267-5",
      "article-title": "Collagen receptor signaling in platelets: extending the role of the ITAM.",
      "volume": "19",
      "author": "Watson",
      "year": "1998",
      "journal-title": "Immunol Today."
    },
    {
      "key": "2020021221030115200_B37",
      "doi-asserted-by": "crossref",
      "first-page": "913",
      "DOI": "10.1016/0092-8674(86)90073-5",
      "article-title": "Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen.",
      "volume": "46",
      "author": "Santoro",
      "year": "1986",
      "journal-title": "Cell."
    },
    {
      "key": "2020021221030115200_B38",
      "doi-asserted-by": "crossref",
      "first-page": "4516",
      "DOI": "10.1016/S0021-9258(18)68811-8",
      "article-title": "The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.",
      "volume": "263",
      "author": "Kunicki",
      "year": "1988",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B39",
      "doi-asserted-by": "crossref",
      "first-page": "182",
      "DOI": "10.1182/blood.V74.1.182.182",
      "article-title": "Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins.",
      "volume": "74",
      "author": "Coller",
      "year": "1989",
      "journal-title": "Blood."
    },
    {
      "key": "2020021221030115200_B40",
      "doi-asserted-by": "crossref",
      "first-page": "470",
      "DOI": "10.1038/318470a0",
      "article-title": "Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia.",
      "volume": "318",
      "author": "Nieuwenhuis",
      "year": "1985",
      "journal-title": "Nature."
    },
    {
      "key": "2020021221030115200_B41",
      "doi-asserted-by": "crossref",
      "first-page": "1074",
      "DOI": "10.1182/blood.V71.4.1074.1074",
      "article-title": "Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder.",
      "volume": "71",
      "author": "Kehrel",
      "year": "1988",
      "journal-title": "Blood."
    },
    {
      "key": "2020021221030115200_B42",
      "doi-asserted-by": "crossref",
      "first-page": "1440",
      "DOI": "10.1172/JCI114318",
      "article-title": "A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion.",
      "volume": "84",
      "author": "Moroi",
      "year": "1989",
      "journal-title": "J Clin Invest."
    },
    {
      "key": "2020021221030115200_B43",
      "doi-asserted-by": "crossref",
      "first-page": "23528",
      "DOI": "10.1074/jbc.272.38.23528",
      "article-title": "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets.",
      "volume": "272",
      "author": "Tsuji",
      "year": "1997",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B44",
      "doi-asserted-by": "crossref",
      "first-page": "267",
      "DOI": "10.1084/jem.188.2.267",
      "article-title": "Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets.",
      "volume": "188",
      "author": "Ezumi",
      "year": "1998",
      "journal-title": "J Exp Med."
    },
    {
      "key": "2020021221030115200_B45",
      "doi-asserted-by": "crossref",
      "first-page": "203",
      "DOI": "10.1042/bj3380203",
      "article-title": "Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets.",
      "volume": "338",
      "author": "Briddon",
      "year": "1999",
      "journal-title": "Biochem J."
    },
    {
      "key": "2020021221030115200_B46",
      "doi-asserted-by": "crossref",
      "first-page": "18095",
      "DOI": "10.1074/jbc.271.30.18095",
      "article-title": "Tyrosine phosphorylation of the Fc receptor \u03b3-chain in collagen-stimulated platelets.",
      "volume": "271",
      "author": "Gibbins",
      "year": "1996",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B47",
      "doi-asserted-by": "crossref",
      "first-page": "27539",
      "DOI": "10.1074/jbc.272.44.27539",
      "article-title": "Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide.",
      "volume": "272",
      "author": "Melford",
      "year": "1997",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B48",
      "doi-asserted-by": "crossref",
      "first-page": "13576",
      "DOI": "10.1074/jbc.272.21.13576",
      "article-title": "Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor.",
      "volume": "272",
      "author": "Polgar",
      "year": "1997",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B49",
      "doi-asserted-by": "crossref",
      "first-page": "28332",
      "DOI": "10.1074/jbc.273.43.28332",
      "article-title": "Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1).",
      "volume": "273",
      "author": "Hua",
      "year": "1998",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B50",
      "doi-asserted-by": "crossref",
      "first-page": "15765",
      "DOI": "10.1074/jbc.273.25.15765",
      "article-title": "Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases.",
      "volume": "273",
      "author": "Cao",
      "year": "1998",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B51",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1016/S0014-5793(99)00446-9",
      "article-title": "Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C\u03b31 with PECAM-1/CD31.",
      "volume": "450",
      "author": "Pumphrey",
      "year": "1999",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "2020021221030115200_B52",
      "doi-asserted-by": "crossref",
      "first-page": "193",
      "DOI": "10.1016/S0955-0674(97)80063-4",
      "article-title": "Protein tyrosine phosphatases in signal transduction.",
      "volume": "9",
      "author": "Neel",
      "year": "1997",
      "journal-title": "Curr Opin Cell Biol."
    },
    {
      "key": "2020021221030115200_B53",
      "doi-asserted-by": "crossref",
      "first-page": "559",
      "DOI": "10.1016/S1357-2725(98)00002-8",
      "article-title": "SHP-2, SH2-containing protein tyrosine phosphatase-2.",
      "volume": "30",
      "author": "Stein-Gerlach",
      "year": "1998",
      "journal-title": "Int J Biochem Cell Biol."
    },
    {
      "key": "2020021221030115200_B54",
      "doi-asserted-by": "crossref",
      "first-page": "47",
      "DOI": "10.1006/excr.1999.4668",
      "article-title": "SHP-2 tyrosine phosphatase: signaling one cell or many.",
      "volume": "253",
      "author": "Feng",
      "year": "1999",
      "journal-title": "Exp Cell Res."
    },
    {
      "key": "2020021221030115200_B55",
      "doi-asserted-by": "crossref",
      "first-page": "21113",
      "DOI": "10.1074/jbc.272.34.21113",
      "article-title": "Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase.",
      "volume": "272",
      "author": "Somani",
      "year": "1997",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B56",
      "doi-asserted-by": "crossref",
      "first-page": "2539",
      "DOI": "10.1002/(SICI)1521-4141(199908)29:08<2539::AID-IMMU2539>3.0.CO;2-M",
      "article-title": "Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP-1.",
      "volume": "29",
      "author": "Brockdorff",
      "year": "1999",
      "journal-title": "Eur J Immunol."
    },
    {
      "key": "2020021221030115200_B57",
      "doi-asserted-by": "crossref",
      "first-page": "697",
      "DOI": "10.1016/S0960-9822(06)00298-3",
      "article-title": "The protein tyrosin phosphatase SHP-2 negatively regulates ciliary neurotrophic induction of gene expression.",
      "volume": "7",
      "author": "Symes",
      "year": "1997",
      "journal-title": "Curr Biol."
    },
    {
      "key": "2020021221030115200_B58",
      "doi-asserted-by": "crossref",
      "first-page": "4904",
      "DOI": "10.1074/jbc.273.9.4904",
      "article-title": "The SHP-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases.",
      "volume": "273",
      "author": "Shi",
      "year": "1998",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B59",
      "doi-asserted-by": "crossref",
      "first-page": "2416",
      "DOI": "10.1128/MCB.19.3.2416",
      "article-title": "Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway.",
      "volume": "19",
      "author": "You",
      "year": "1999",
      "journal-title": "Mol Cell Biol."
    },
    {
      "key": "2020021221030115200_B60",
      "doi-asserted-by": "crossref",
      "first-page": "28526",
      "DOI": "10.1074/jbc.M001531200",
      "article-title": "Evidence for a role of SHP-1 in platelet activation by the collagen receptor GPVI.",
      "volume": "275",
      "author": "Pasquet",
      "year": "2000",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B61",
      "doi-asserted-by": "crossref",
      "first-page": "783",
      "DOI": "10.1006/bbrc.1996.0139",
      "article-title": "Cloning and chromosomal localization of the human P2Y1 purinoceptor 35.",
      "volume": "218",
      "author": "Ayyanathan",
      "year": "1996",
      "journal-title": "Biochem Biophys Res Commun."
    },
    {
      "key": "2020021221030115200_B62",
      "doi-asserted-by": "crossref",
      "first-page": "2024",
      "DOI": "10.1074/jbc.273.4.2024",
      "article-title": "Molecular basis for ADPinduced platelet activation, I: evidence for three distinct ADP receptors on human platelets.",
      "volume": "273",
      "author": "Daniel",
      "year": "1998",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B63",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1016/S0002-9440(10)64519-1",
      "article-title": "PECAM-1 (CD31) expression modulates bleeding time in vivo.",
      "volume": "157",
      "author": "Mahooti",
      "year": "2000",
      "journal-title": "Am J Pathol."
    },
    {
      "key": "2020021221030115200_B64",
      "doi-asserted-by": "crossref",
      "first-page": "7029",
      "DOI": "10.1074/jbc.270.13.7029",
      "article-title": "Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.",
      "volume": "270",
      "author": "Jackman",
      "year": "1995",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B65",
      "doi-asserted-by": "crossref",
      "first-page": "5963",
      "DOI": "10.1074/jbc.274.9.5963",
      "article-title": "Tyrosine phosphorylation of SLP-76 is downstream of syk following stimulation of the collagen receptor in platelets.",
      "volume": "274",
      "author": "Gross",
      "year": "1999",
      "journal-title": "J Biol Chem."
    },
    {
      "key": "2020021221030115200_B66",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1172/JCI5317",
      "article-title": "Fetal hemorrhage and platelet dysfunction in SLP-76\u2013deficient mice.",
      "volume": "103",
      "author": "Clements",
      "year": "1999",
      "journal-title": "J Clin Invest."
    },
    {
      "key": "2020021221030115200_B67",
      "doi-asserted-by": "crossref",
      "first-page": "83",
      "DOI": "10.1016/S0092-8674(00)80901-0",
      "article-title": "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.",
      "volume": "92",
      "author": "Zhang",
      "year": "1998",
      "journal-title": "Cell."
    },
    {
      "key": "2020021221030115200_B68",
      "doi-asserted-by": "crossref",
      "first-page": "8326",
      "DOI": "10.1128/MCB.19.12.8326",
      "article-title": "LAT is required for tyrosine phosphorylation of phospholipase C\u03b32 and platelet activation by the collagen receptor GPVI.",
      "volume": "19",
      "author": "Pasquet",
      "year": "1999",
      "journal-title": "Mol Cell Biol."
    }
  ],
  "container-title": "Blood",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://ashpublications.org/blood/article-pdf/97/6/1727/1672753/h8060101727.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "http://ashpublications.org/blood/article-pdf/97/6/1727/1672753/h8060101727.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        6
      ]
    ],
    "date-time": "2024-01-06T06:43:23Z",
    "timestamp": 1704523403000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://ashpublications.org/blood/article/97/6/1727/107376/Platelet-endothelial-cell-adhesion-molecule1"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        3,
        15
      ]
    ]
  },
  "references-count": 68,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2001,
          3,
          15
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1182/blood.V97.6.1727",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.13409079.14780093",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "1528-0020",
    "0006-4971"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2001,
        3,
        15
      ]
    ]
  }
}