DOI: 10.1182/blood.v97.4.911. Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

10.1182/blood.v97.4.911

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract Shp-1 and Shp-2 are cytoplasmic phosphotyrosine phosphatases with similar structures. Mice deficient in Shp-2 die at midgestation with defects in mesodermal patterning, and a hypomorphic mutation at the Shp-1 locus results in the moth-eaten viable (mev) phenotype. Previously, a critical role of Shp-2 in mediating erythroid/myeloid cell development was demonstrated. By using the RAG-2–deficient blastocyst complementation, the role of Shp-2 in lymphopoiesis has been determined. Chimeric mice generated by injecting Shp-2−/− embryonic stem cells into Rag-2–deficient blastocysts had no detectable mature T and B cells, serum immunoglobulin M, or even Thy-1+ and B220+ precursor lymphocytes. Collectively, these results suggest a positive role of Shp-2 in the development of all blood cell lineages, in contrast to the negative effect of Shp-1 in this process. To determine whether Shp-1 and Shp-2 interact in hematopoiesis, Shp-2−/−:mev/mev double-mutant embryos were generated and the hematopoietic cell development in the yolk sacs was examined. More hematopoietic stem/progenitor cells were detected in Shp-2−/−:mev/mevembryos than in Shp-2−/− littermates. The partial rescue by Shp-1 deficiency of the defective hematopoiesis caused by the Shp-2 mutation suggests that Shp-1 and Shp-2 have antagonistic effects in hematopoiesis, possibly through a bidirectional modulation of the same signaling pathway(s).

Bibliography

Qu, C.-K., Nguyen, S., Chen, J., & Feng, G.-S. (2001). Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development. Blood, 97(4), 911â914.

Authors 4

Cheng-Kui Qu (first)
Suzanne Nguyen (additional)
Jianzhu Chen (additional)
Gen-Sheng Feng (additional)

References 22 Referenced 91

10.1016/0168-9525(94)90149-X / Trends Genet. / Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. by Feng (1994)
10.1006/excr.1999.4668 / Exp Cell Res. / Shp-2 tyrosine phosphatase: signaling one cell or many. by Feng (1999)
10.1006/scel.1993.1050 / Semin Cell Biol. / Structure and function of SH2-domain containing tyrosine phosphatases. by Neel (1993)
10.1006/smim.1998.0125 / Semin Immunol. / Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases. by Siminovitch (1998)
10.1016/S0092-8674(00)81790-0 / Cell. / The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP? by Scharenberg (1996)
10.1093/emboj/16.9.2352 / EMBO J. / Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. by Saxton (1997)
10.1128/MCB.17.9.5499 / Mol Cell Biol. / A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. by Qu (1997)
10.1128/MCB.18.10.6075 / Mol Cell Biol. / Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. by Qu (1998)
10.1038/ng0693-124 / Nat Genet. / Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. by Tsui (1993)
10.1016/0092-8674(93)90369-2 / Cell. / Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. by Shultz (1993)
10.1111/j.1600-065X.1994.tb00852.x / Immunol Rev. / Molecular basis of the motheaten phenotype. by Tsui (1994)
10.1126/science.272.5265.1170 / Science. / Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. by Marengere (1996)
10.1126/science.282.5397.2263 / Science. / Molecular basis of T cell inactivation by CTLA-4. by Lee (1998)
10.1073/pnas.90.10.4528 / Proc Natl Acad Sci U S A. / Rag-2–deficient blastocyst complementation: an assay of gene function in lymphocyte development. by Chen (1993)
10.1016/0952-7915(94)90107-4 / Curr Opin Immunol. / Probing immune functions in RAG-deficient mice. by Chen (1994)
10.1084/jem.190.5.681 / J Exp Med. / Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses. by Kim (1999)
{'key': '2020021217021109900_B17', 'first-page': '6.4.1', 'article-title': 'Measurement of interleukin-3 and other hematopoietic growth factors, such as GM-CSF, G-CSF, M-CSF, erythropoietin and the other potent co-stimulating cytokines steel factor and Flt-3 ligand.', 'volume': '18(suppl)', 'author': 'Cooper', 'year': '1996', 'journal-title': 'Curr Protocols Immunol.'} / Curr Protocols Immunol. / Measurement of interleukin-3 and other hematopoietic growth factors, such as GM-CSF, G-CSF, M-CSF, erythropoietin and the other potent co-stimulating cytokines steel factor and Flt-3 ligand. by Cooper (1996)
10.1016/S0065-2776(08)60427-7 / Adv Immunol. / Analysis of gene function in lymphocytes by Rag-2–deficient blastocyst complementation. by Chen (1996)
10.1016/S0092-8674(00)81069-7 / Cell. / Fibroblast growth factor receptor 3 is a negative regulator of bone growth. by Deng (1996)
10.1016/S1074-7613(00)80162-4 / Immunity. / Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. by Ohtani (2000)
10.1073/pnas.100135197 / Proc Natl Acad Sci U S A. / Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. by Nicholson (2000)
10.1084/jem.187.8.1355 / J Exp Med. / Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal. by Maeda (1998)

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 4:46 a.m.)
Deposited	5 years, 6 months ago (Feb. 12, 2020, 12:46 p.m.)
Indexed	11 months, 2 weeks ago (Sept. 20, 2024, 11:11 a.m.)
Issued	24 years, 6 months ago (Feb. 15, 2001)
Published	24 years, 6 months ago (Feb. 15, 2001)
Published Print	24 years, 6 months ago (Feb. 15, 2001)

Funders 0

None

BibTeX

@article{Qu_2001, title={Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development}, volume={97}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood.v97.4.911}, DOI={10.1182/blood.v97.4.911}, number={4}, journal={Blood}, publisher={American Society of Hematology}, author={Qu, Cheng-Kui and Nguyen, Suzanne and Chen, Jianzhu and Feng, Gen-Sheng}, year={2001}, month=feb, pages={911–914} }

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