DOI: 10.1182/blood.v96.13.4328. BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration

BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration

10.1182/blood.v96.13.4328

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract Clinical risk factor models such as the International Prognostic Index are used to identify diffuse large B-cell lymphoma (DLB-CL) patients with different risks of death from their diseases. To elucidate the molecular bases for these observed clinical differences in outcome, differential display was used to identify a novel gene, termed BAL (B-aggressivelymphoma), which is expressed at significantly higher levels in fatal high-risk DLB-CLs than in cured low-risk tumors. The major BAL complementary DNA encodes a previously uncharacterized 88-kd nuclear protein with a duplicated N-terminal domain homologous to the nonhistone portion of histone-macroH2A and a C-terminal alpha-helical region with 2 short coiled-coil domains. Of note, the BAL N-terminus and secondary structure resemble those of a recently identified human protein, KIAA1268. In addition, bothBAL and KIAA1268 map to chromosome 3q21, further suggesting that these genes belong to a newly identified family. BAL is expressed at increased levels in DLB-CL cell lines with an activated peripheral B cell, rather than a germinal center B cell, phenotype. This observation and the characteristic dissemination of high risk DLB-CLs prompted studies regarding the role of BAL in B-cell migration. In classical transwell assays, stable BAL-overexpressing B-cell lymphoma transfectants had significantly higher rates of migration than vector-only transfectants, indicating that the risk-related BAL gene promotes malignant B-cell migration.

Bibliography

Aguiar, R. C. T., Yakushijin, Y., Kharbanda, S., Salgia, R., Fletcher, J. A., & Shipp, M. A. (2000). BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. Blood, 96(13), 4328â4334.

Authors 6

Ricardo C. T. Aguiar (first)
Yoshihiro Yakushijin (additional)
Samir Kharbanda (additional)
Ravi Salgia (additional)
Jonathan A. Fletcher (additional)
Margaret A. Shipp (additional)

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Dates

Type	When
Created	5 years, 10 months ago (Oct. 14, 2019, 3:49 a.m.)
Deposited	5 years, 6 months ago (Feb. 12, 2020, 6:55 p.m.)
Indexed	1 month ago (July 25, 2025, 6:51 a.m.)
Issued	24 years, 8 months ago (Dec. 15, 2000)
Published	24 years, 8 months ago (Dec. 15, 2000)
Published Print	24 years, 8 months ago (Dec. 15, 2000)

Funders 0

None

BibTeX

@article{Aguiar_2000, title={BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration}, volume={96}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood.v96.13.4328}, DOI={10.1182/blood.v96.13.4328}, number={13}, journal={Blood}, publisher={American Society of Hematology}, author={Aguiar, Ricardo C. T. and Yakushijin, Yoshihiro and Kharbanda, Samir and Salgia, Ravi and Fletcher, Jonathan A. and Shipp, Margaret A.}, year={2000}, month=dec, pages={4328–4334} }

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