DOI: 10.1182/blood.v96.1.170. Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor

Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor

10.1182/blood.v96.1.170

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

AbstractWe describe thrombogenic tissue factor (TF) on leukocyte-derived microparticles and their incorporation into spontaneous human thrombi. Polymorphonuclear leukocytes and monocytes transfer TF+particles to platelets, thereby making them capable of triggering and propagating thrombosis. This phenomenon calls into question the original dogma that vessel wall injury and exposure of TF within the vasculature to blood is sufficient for the occurrence of arterial thrombosis. The transfer of TF+ leukocyte-derived particles is dependent on the interaction of CD15 and TF with platelets. Both the inhibition of TF transfer to platelets by antagonizing the interaction CD15 with P-selectin and the direct interaction of TF itself suggest a novel therapeutic approach to prevent thrombosis.

Bibliography

Rauch, U., Bonderman, D., Bohrmann, B., Badimon, J. J., Himber, J., Riederer, M. A., & Nemerson, Y. (2000). Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor. Blood, 96(1), 170â175.

Authors 7

Ursula Rauch (first)
Diana Bonderman (additional)
Bernd Bohrmann (additional)
Juan J. Badimon (additional)
Jacques Himber (additional)
Markus A. Riederer (additional)
Yale Nemerson (additional)

References 36 Referenced 309

10.1126/science.175.4023.766 / Science. / Tissue factor (thromboplastin): localization to plasma membranes by peroxidase-conjugated antibodies. by Zeldis (1972)
10.1016/S0140-6736(96)98003-4 / Lancet. / Coronary thrombosis. by Fuster (1996)
10.1055/s-0038-1657534 / Thromb Haemost. / The unstable atherosclerotic plaque: clinical significance and therapeutic intervention. by Fuster (1997)
10.1073/pnas.96.5.2311 / Proc Natl Acad Sci U S A. / Blood-borne tissue factor: another view of thrombosis. by Giesen (1999)
10.1016/S0002-8703(97)70132-7 / Am Heart J. / Increased plasma tissue factor levels in acute myocardial infarction. by Suefuji (1997)
10.1182/blood.V91.11.4216 / Blood. / Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease. by Key (1998)
10.1006/jsre.1998.5348 / J Surg Res. / Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils. by Todoroki (1998)
10.1172/JCI107891 / J Clin Invest. / The stimulatory effect of platelets and platelet membranes on the procoagulant activity of leukocytes. by Niemetz (1974)
10.1002/jlb.54.4.275 / J Leukoc Biol. / Granulocytes enhance LPS-induced tissue factor activity in monocytes via an interaction with platelets. by Halvorsen (1993)
10.1016/0092-8674(90)90443-I / Cell. / PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). by Larsen (1990)
10.1074/jbc.270.19.11025 / J Biol Chem. / Leukocyte trafficking mediated by selectin-carbohydrate interactions. by McEver (1995)
10.1016/0092-8674(89)90636-3 / Cell. / Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. by Johnston (1989)
10.1152/physrev.1999.79.1.181 / Physiol Rev. / Mechanisms that regulate the function of the selectins and their ligands. by Vestweber (1999)
10.1016/S0076-6879(81)80020-1 / Methods Enzymol. by Miletich (1981)
{'key': '2020021220401533500_B15', 'first-page': '451', 'article-title': 'In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X [published correction appears in Lab Invest. 1997;76:297].', 'volume': '75', 'author': 'Thiruvikraman', 'year': '1996', 'journal-title': 'Lab Invest.'} / Lab Invest. / In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X [published correction appears in Lab Invest. 1997;76:297]. by Thiruvikraman (1996)
10.1182/blood.V70.2.490.490 / Blood. / An inhibitory monoclonal antibody against human tissue factor. by Carson (1987)
10.1016/0002-9149(89)90728-5 / Am J Cardiol. / Effects of contrast media on endothelial cell monolayers under controlled flow conditions. by Grabowski (1989)
10.1083/jcb.9.2.409 / J Biophys Biochem Cytol. / Improvements in epoxy resin embedding methods. by Luft (1961)
10.1083/jcb.17.1.208 / J Cell Biol. / The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. by Reynolds (1963)
10.1007/BF01011956 / Histochem J. / Immunochemistry on ultrathin frozen sections. by Tokuyasu (1980)
10.1016/S0049-3848(97)00014-5 / Thromb Res. / A new method for quantitative analysis of whole blood platelet interaction with extracellular matrix under flow conditions. by Varon (1997)
10.1182/blood.V72.1.128.bloodjournal721128 / Blood. / Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes. by Conkling (1988)
10.1182/blood.V80.4.966.966 / Blood. / Tumor necrosis factor-induced endothelial tissue factor is associated with subendothelial matrix particles but is not expressed on the apical surface. by Ryan (1992)
10.1038/359848a0 / Nature. / Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. by Palabrica (1992)
10.1182/blood.V87.4.1238.bloodjournal8741238 / Blood. / Defects in hemostasis in P-selectin-deficient mice. by Subramaniam (1996)
10.1182/blood.V83.9.2498.2498 / Blood. / Role of P-selectin and leukocyte activation in polymorphonuclear cell adhesion to surface adherent activated platelets under physiologic shear conditions (an injury vessel wall model). by Yeo (1994)
10.1161/01.ATV.19.4.1083 / Arterioscler Thromb Vasc Biol. / Adhesive interaction between P-selectin and sialyl Lewis(x) plays an important role in recurrent coronary arterial thrombosis in dogs. by Ikeda (1999)
10.1182/blood.V93.10.3451.410k27_3451_3456 / Blood. / Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia. by Hugel (1999)
10.1172/JCI119317 / J Clin Invest. / The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection. by Aupeix (1997)
10.1182/blood.V92.11.4167 / Blood. / Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitro. by Randolph (1998)
10.1083/jcb.140.5.1241 / J Cell Biol. / A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280. by Ott (1998)
10.1006/excr.1999.4395 / Exp Cell Res. / Localization of tissue factor in actin-filament-rich membrane areas of epithelial cells. by Muller (1999)
10.1097/00001721-199809000-00012 / Blood Coagul Fibrinolysis. / Tissue factor and cell morphology variations in cell lines subcloned from U87-MG. by Carson (1998)
10.1016/S0021-9258(19)49554-9 / J Biol Chem. / Relations between factor VIIa binding and expression of factor VIIa/tissue factor catalytic activity on cell surfaces. by Le (1992)
10.1073/pnas.87.18.6995 / Proc Natl Acad Sci U S A. / Expression of tissue factor procoagulant activity: regulation by cytosolic calcium. by Bach (1990)
10.1172/JCI107992 / J Clin Invest. / Association of tissue factor activity with the surface of cultured cells. by Maynard (1975)

Dates

Type	When
Created	5 years, 10 months ago (Oct. 14, 2019, 7:52 a.m.)
Deposited	4 years, 7 months ago (Jan. 24, 2021, 2:26 p.m.)
Indexed	2 months, 2 weeks ago (June 18, 2025, 8:27 a.m.)
Issued	25 years, 2 months ago (July 1, 2000)
Published	25 years, 2 months ago (July 1, 2000)
Published Print	25 years, 2 months ago (July 1, 2000)

Funders 0

None

BibTeX

@article{Rauch_2000, title={Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor}, volume={96}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood.v96.1.170}, DOI={10.1182/blood.v96.1.170}, number={1}, journal={Blood}, publisher={American Society of Hematology}, author={Rauch, Ursula and Bonderman, Diana and Bohrmann, Bernd and Badimon, Juan J. and Himber, Jacques and Riederer, Markus A. and Nemerson, Yale}, year={2000}, month=jul, pages={170–175} }

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      "volume": "134",
      "author": "Suefuji",
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      "author": "Todoroki",
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      "volume": "54",
      "author": "Halvorsen",
      "year": "1993",
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      "journal-title": "Cell."
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      "volume": "270",
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      "author": "Thiruvikraman",
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