DOI: 10.1182/blood.v94.7.2403.419k39_2403_2413. PTPROt: An Alternatively Spliced and Developmentally Regulated B-Lymphoid Phosphatase That Promotes G0/G1 Arrest

PTPROt: An Alternatively Spliced and Developmentally Regulated B-Lymphoid Phosphatase That Promotes G0/G1 Arrest

10.1182/blood.v94.7.2403.419k39_2403_2413

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Protein tyrosine phosphatases (PTP) regulate the proliferation, differentiation, and viability of lymphocytes by modulating their signaling pathways. By using the differential display assay, we have cloned a putative receptor-type PTP, which is predominantly expressed in B-lymphoid tissues (lymph nodes and spleen). This PTP, termed PTPROt (truncated), is a tissue-specific alternatively-spliced form of a human epithelial PTP, PTPRO (PTPU2/GLEPP1). Whereas the epithelial PTPRO includes an ≈800-amino acid extracellular domain, the major (3 kb) PTPROt cDNA predicts a unique 5′ untranslated region and truncated (8 amino acids) extracellular domain with a conserved transmembrane region and single catalytic domain. PTPROt cDNAs encode functional ∼47-kD and ∼43-kD PTPs, which are most abundant in normal naive quiescent B cells and decreased or absent in germinal center B cells and germinal center-derived diffuse large B-cell lymphomas. Because PTPROt was predominantly expressed in naive quiescent B cells, the enzyme’s effects on cell-cycle progression were examined. When multiple stable PTPROt sense, antisense, and vector only B-cell transfectants were grown in reduced serum and synchronized with nocodazole, PTPROt sense clones exhibited markedly increased G0/G1 arrest. Taken together, these data implicate PTPROt in the growth control of specific B-cell subpopulations.

Bibliography

Aguiar, R. C. T., Yakushijin, Y., Kharbanda, S., Tiwari, S., Freeman, G. J., & Shipp, M. A. (1999). PTPROt: An Alternatively Spliced and Developmentally Regulated B-Lymphoid Phosphatase That Promotes G0/G1 Arrest. Blood, 94(7), 2403â2413.

Authors 6

Ricardo C.T. Aguiar (first)
Yoshihiro Yakushijin (additional)
Samir Kharbanda (additional)
Sanjay Tiwari (additional)
Gordon J. Freeman (additional)
Margaret A. Shipp (additional)

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Dates

Type	When
Created	5 years, 10 months ago (Oct. 11, 2019, 7:49 a.m.)
Deposited	1 year, 11 months ago (Sept. 21, 2023, 10:26 a.m.)
Indexed	1 month, 3 weeks ago (July 14, 2025, 11:22 p.m.)
Issued	25 years, 11 months ago (Oct. 1, 1999)
Published	25 years, 11 months ago (Oct. 1, 1999)
Published Print	25 years, 11 months ago (Oct. 1, 1999)

Funders 0

None

BibTeX

@article{Aguiar_1999, title={PTPROt: An Alternatively Spliced and Developmentally Regulated B-Lymphoid Phosphatase That Promotes G0/G1 Arrest}, volume={94}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood.v94.7.2403.419k39_2403_2413}, DOI={10.1182/blood.v94.7.2403.419k39_2403_2413}, number={7}, journal={Blood}, publisher={American Society of Hematology}, author={Aguiar, Ricardo C.T. and Yakushijin, Yoshihiro and Kharbanda, Samir and Tiwari, Sanjay and Freeman, Gordon J. and Shipp, Margaret A.}, year={1999}, month=oct, pages={2403–2413} }

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