DOI: 10.1182/blood.v90.11.4628. Prevalence and Natural History of Hepatitis C Infection in Patients Cured of Childhood Leukemia

Prevalence and Natural History of Hepatitis C Infection in Patients Cured of Childhood Leukemia

10.1182/blood.v90.11.4628

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract The aim of this study was to ascertain prevalence and natural history of hepatitis C virus (HCV) infection in a large cohort of patients cured of childhood leukemia who had been followed prospectively for liver disease for at least 10 years since chemotherapy withdrawal: 114 consecutive patients entered the study. Liver function tests and ultrasonography were used to assess presence of liver disease. Patients were tested for antibody to HCV and for serum HCV-RNA at the end of chemotherapy and at the end of follow-up. At chemotherapy withdrawal, 56 patients (49%) were HCV-RNA positive, often without detectable anti-HCV, and in these cases, transaminase levels were more elevated during (P = .08) and after (P = .04) chemotherapy compared with HCV-RNA negative cases. Patients were then followed-up 13 to 27 years (mean, 17) after chemotherapy withdrawal. During this period, 38 initially anti-HCV negative patients seroconverted to anti-HCV and 17 initially anti-HCV positive cases lost reactivity. Forty patients were persistently HCV-RNA positive in serum, while 16 initially viremic patients became HCV-RNA negative during follow-up. At the end of the observation period, a persistent transaminase elevation was detected only in four HCV-RNA positive and anti-HCV positive cases, while no patient developed signs or symptoms of decompensated liver disease. Thus, hepatitis C was a frequent finding in long-term survivors after chemotherapy. It was associated with an atypical serologic profile and did not cause severe liver impairment over a period of 13 to 27 years.

Bibliography

Locasciulli, A., Testa, M., Pontisso, P., BenvegnuÌ, L., Fraschini, D., Corbetta, A., Noventa, F., Masera, G., & Alberti, A. (1997). Prevalence and Natural History of Hepatitis C Infection in Patients Cured of Childhood Leukemia. Blood, 90(11), 4628â4633.

Authors 9

Anna Locasciulli (first)
Marina Testa (additional)
Patrizia Pontisso (additional)
Luisa Benvegnù (additional)
Donatella Fraschini (additional)
Adele Corbetta (additional)
Franco Noventa (additional)
Giuseppe Masera (additional)
Alfredo Alberti (additional)

References 17 Referenced 109

10.1002/1097-0142(19830915)52:6<1080::AID-CNCR2820520625>3.0.CO;2-K / Cancer / Chronic liver disease in children with leukemia in long-term remission. by Locasciulli (1983)
10.1016/S0140-6736(82)91392-7 / Lancet / Histologic evidence of hepatitis B virus infection with negative serology in children with acute leukemia who develop chronic liver disease. by Vergani (1982)
{'key': '2019112010121036800_B3', 'first-page': '354', 'article-title': 'Evidence of non-A, non-B hepatitis in children with acute leukemia and chronic liver disease.', 'volume': '137', 'author': 'Locasciulli', 'year': '1983', 'journal-title': 'Am J Dis Child'} / Am J Dis Child / Evidence of non-A, non-B hepatitis in children with acute leukemia and chronic liver disease. by Locasciulli (1983)
10.1182/blood.V78.6.1619.1619 / Blood / Hepatitis C virus infection and chronic liver disease in children with leukemia in long-term remission. by Locasciulli (1991)
10.1182/blood.V84.9.2919.2919 / Blood / Hepatitis C virus infection in children treated for acute lymphoblastic leukemia. by Aricò (1994)
10.1182/blood.V83.7.1998.1998 / Blood / Hepatitis C virus infection is a risk factor for liver failure from veno-occlusive disease after bone marrow transplantation. by Frickhofen (1994)
{'key': '2019112010121036800_B7'}
10.1002/hep.1840150532 / Hepatology / Hepatocellular carcinoma: Recent progress. by Okuda (1992)
10.1016/0928-4346(94)90020-5 / Int Hepatol Commun / Genotype of hepatitis C virus in Italian patients with chronic hepatitis C. by Tisminetzky (1994)
10.1056/NEJM199506013322202 / N Engl J Med / Clinical outcomes after transfusion-associated hepatitis C. by Tong (1995)
10.1056/NEJM199212313272703 / N Engl J Med / Long-term mortality after transfusion-associated non-A, non-B hepatitis. by Seeff (1992)
10.7326/0003-4819-119-2-199307150-00003 / Ann Intern Med / Non-A, non-B post-transfusion hepatitis: Looking back in the second decade. by Koretz (1993)
10.1002/jmv.1890430318 / J Med Virol / Different genotypes of hepatitis C virus are associated with different severity of chronic liver disease. by Pozzato (1994)
10.7326/0003-4819-122-3-199502010-00001 / Ann Intern Med / Hepatitis C virus type 1b (II) infection in France and Italy. by Nousbaum (1995)
10.7326/0003-4819-123-5-199509010-00001 / Ann Intern Med / Assessment of hepatitis C viremia using molecular amplification technologies: Correlations and clinical implications. by Gretch (1995)
10.1182/blood.V85.5.1259.bloodjournal8551259 / Blood / Heterogeneity of hepatitis C virus genotypes in hemophilia: Relationship with chronic liver disease. by Preston (1995)
10.1002/hep.1840210308 / Hepatology / Incidence of hepatocellular carcinoma in chronic hepatitis B and C: A prospective study of 251 patients. by Takano (1995)

Dates

Type	When
Created	5 years, 10 months ago (Oct. 13, 2019, 6:22 p.m.)
Deposited	5 years, 9 months ago (Nov. 20, 2019, 5:13 a.m.)
Indexed	11 months, 4 weeks ago (Sept. 6, 2024, 5:32 a.m.)
Issued	27 years, 9 months ago (Dec. 1, 1997)
Published	27 years, 9 months ago (Dec. 1, 1997)
Published Print	27 years, 9 months ago (Dec. 1, 1997)

Funders 0

None

BibTeX

@article{Locasciulli_1997, title={Prevalence and Natural History of Hepatitis C Infection in Patients Cured of Childhood Leukemia}, volume={90}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood.v90.11.4628}, DOI={10.1182/blood.v90.11.4628}, number={11}, journal={Blood}, publisher={American Society of Hematology}, author={Locasciulli, Anna and Testa, Marina and Pontisso, Patrizia and Benvegnù, Luisa and Fraschini, Donatella and Corbetta, Adele and Noventa, Franco and Masera, Giuseppe and Alberti, Alfredo}, year={1997}, month=dec, pages={4628–4633} }

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