DOI: 10.1182/blood.v90.1.126.126_126_137. Features of Macrophage Differentiation Induced by p19INK4d, a Specific Inhibitor of Cyclin D

Features of Macrophage Differentiation Induced by p19INK4d, a Specific Inhibitor of Cyclin D–Dependent Kinases

10.1182/blood.v90.1.126.126_126_137

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

The mitogen-dependent induction of cyclin D–dependent kinase activity is required for cells to enter the DNA synthetic (S) phase of their division cycle. Immature 32Dcl3 myeloid cells (32D) proliferating in the presence of interleukin-3 (IL-3) normally express cyclins D2 and D3, which assemble into binary holoenzyme complexes with their catalytic subunits, CDK4 and CDK6. When 32D cells are switched to medium containing granulocyte colony-stimulating factor (G-CSF ) instead of IL-3, D-type cyclins are degraded and, in the absence of their associated kinase activity, the cells arrest in the first gap phase (G1 ) of the cell cycle and differentiate to neutrophils. We derived 32D cells in which the expression of p19INK4d, a specific polypeptide inhibitor of CDK4 and CDK6, is regulated by the heavy metal-inducible sheep metallothionein promoter. Induction of p19INK4d in response to zinc prolonged cell survival in the absence of growth factor treatment. When maintained in medium containing both IL-3 and zinc, these cells lost cyclin D–dependent kinase activity, underwent G1 phase arrest, and acquired certain morphologic, antigenic, and functional properties of mononuclear phagocytes. Cells induced to express p19INK4d did not synthesize receptors for macrophage colony-stimulating factor (M-CSF/CSF-1) and reverted to an immature myeloid phenotype when shifted back into medium containing IL-3 alone. These cells exhibited accelerated differentiation to neutrophils in response to G-CSF but also gave rise to macrophage-like cells when maintained in medium containing both G-CSF and zinc. Therefore, the acquisition of macrophage properties in response to zinc treatment neither depended upon IL-3 nor upon G1 phase arrest per se and instead reflects some ability of p19INK4d, and presumably cyclin D–dependent kinases, to affect myeloid differentiation.

Bibliography

Adachi, M., Roussel, M. F., Havenith, K., & Sherr, C. J. (1997). Features of Macrophage Differentiation Induced by p19INK4d, a Specific Inhibitor of Cyclin DâDependent Kinases. Blood, 90(1), 126â137.

Authors 4

Masashi Adachi (first)
Martine F. Roussel (additional)
Karin Havenith (additional)
Charles J. Sherr (additional)

References 80 Referenced 18

10.1038/344503a0 / Nature / Universal control mechanism regulating onset of M-phase. by Nurse (1990)
10.1016/0092-8674(93)90636-5 / Cell / Mammalian G1 cyclins. by Sherr (1993)
10.1016/0092-8674(94)90540-1 / Cell / G1 phase progression: Cycling on cue. by Sherr (1994)
10.1016/0092-8674(95)90385-2 / Cell / The retinoblastoma protein and cell cycle control. by Weinberg (1995)
10.1126/science.1411535 / Science / E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. by Nevins (1992)
10.1016/0968-0004(94)90202-X / Trends Biochem Sci / DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell cycle control. by La Thangue (1994)
10.1073/pnas.91.2.709 / Proc Natl Acad Sci USA / Function of a human cyclin gene as an oncogene. by Hinds (1994)
10.1101/gad.8.15.1759 / Genes Dev / Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. by Hatakeyama (1994)
10.1128/MCB.15.5.2612 / Mol Cell Biol / Human cyclin E, a nuclear protein essential for the G1 to S phase transition. by Ohtsubo (1995)
10.1126/science.2683075 / Science / G1 events and regulation of cell proliferation. by Pardee (1989)
10.1126/science.274.5293.1672 / Science / Cancer cell cycles. by Sherr (1996)
10.1101/gad.7.5.812 / Genes Dev / Cyclin D1 is a nuclear protein required for cell cycle progression in G1. by Baldin (1993)
10.1101/gad.7.8.1559 / Genes Dev / Overexpression of mouse D-type cyclins accelerates G1 , phase in rodent fibroblasts. by Quelle (1993)
10.1128/MCB.15.5.2600 / Mol Cell Biol / Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells, independent of CDK4 activity. by Lukas (1995)
10.1016/0092-8674(91)90101-4 / Cell / Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. by Matsushime (1991)
10.1038/366704a0 / Nature / A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/cdk4. by Serrano (1993)
10.1038/371257a0 / Nature / p15INK4b is a potential effector of cell cycle arrest mediated by TGF-β. by Hannon (1994)
10.1101/gad.8.24.2939 / Genes Dev / Growth suppression by p18, a p16INK4/MTS1- and p14INK4/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. by Guan (1994)
10.1128/MCB.15.5.2672 / Mol Cell Biol / Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. by Hirai (1995)
10.1128/MCB.15.5.2682 / Mol Cell Biol / Identification of human/mouse p19, a novel cdk4/cdk6 inhibitor with homology to p16ink4. by Chan (1995)
10.1038/375503a0 / Nature / Rb-dependent cell cycle inhibition by p16CDKN2 tumour suppressor. by Lukas (1995)
10.1038/375506a0 / Nature / Tumour-derived p16 alleles encoding proteins defective in cell cycle inhibition. by Koh (1995)
10.1126/science.7809631 / Science / Inhibition of ras-induced proliferation and cellular transformation by p16INK4. by Serrano (1995)
10.1073/pnas.92.14.6289 / Proc Natl Acad Sci USA / Growth suppression by p16ink4 requires functional retinoblastoma protein. by Medema (1995)
10.1101/gad.9.15.1831 / Genes Dev / Kip/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. by Reynisdóttir (1995)
10.1073/pnas.90.20.9571 / Proc Nat Acad Sci USA / Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells. by Ando (1993)
10.1073/pnas.90.24.11513 / Proc Natl Acad Sci USA / Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1. by Kato (1993)
10.1073/pnas.80.10.2931 / Proc Natl Acad Sci USA / Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. by Greenberger (1983)
10.4049/jimmunol.138.11.3829 / J Immunol / Cytokine-dependent granulocytic differentiation. by Valtieri (1987)
10.1038/382541a0 / Nature / Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. by Inaba (1996)
10.1182/blood.V75.9.1780.1780 / Blood / Human colony-stimulating factor 1 (CSF-1) receptor confers CSF-1 responsiveness to interleukin-3-dependent 32DCL3 mouse myeloid cells and abrogates differentiation in response to granulocyte CSF. by Kato (1990)
10.1128/MCB.8.4.1795 / Mol Cell Biol / Ligand-induced tyrosine kinase activity of the colony stimulating factor-1 receptor in a murine macrophage cell line. by Downing (1988)
10.1101/gad.7.3.331 / Genes Dev / Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase, CDK4. by Kato (1993)
10.1089/hyb.1994.13.37 / Hybridoma / Monoclonal antibodies to mammalian D-type G1 cyclins. by Vallance (1993)
10.1128/MCB.14.3.2066 / Mol Cell Biol / D-type cyclin-dependent kinase activity in mammalian cells. by Matsushime (1994)
10.1128/MCB.14.3.2077 / Mol Cell Biol / Identification of a G1 kinase activity for cdk6, a novel cyclin D partner. by Meyerson (1994)
10.1016/0092-8674(92)90360-O / Cell / Identification and properties of an atypical catalytic subunit (p34PSKJ3/CDK4) for mammalian D-type G1 cyclins. by Matsushime (1992)
10.1016/0092-8674(93)90136-E / Cell / Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. by Ewen (1993)
10.1002/jcp.1041300316 / J Cell Physiol / Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5. by Morgan (1987)
10.1016/S0092-8674(85)80047-7 / Cell / The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. by Sherr (1985)
10.1016/0042-6822(86)90145-5 / Virology / Antibodies to distal carboxyl terminal epitopes in the v-fms-coded glycoprotein do not cross-react with the c-fms gene product. by Furman (1986)
10.1182/blood.V73.3.827.827 / Blood / Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells. by Ashmun (1989)
10.1016/0092-8674(85)90357-5 / Cell / Transmembrane orientation of glycoproteins encoded by the v-fms oncogene. by Rettenmier (1985)
{'key': '2019112003383643200_B44', 'first-page': '311', 'article-title': 'Murine c-fms cDNA: Cloning, sequence analysis, and retroviral expression.', 'volume': '1', 'author': 'Rothwell', 'year': '1987', 'journal-title': 'Oncogene Res'} / Oncogene Res / Murine c-fms cDNA: Cloning, sequence analysis, and retroviral expression. by Rothwell (1987)
{'key': '2019112003383643200_B45'}
10.1159/000186211 / Nephron / Short dwell times reduce the local defense mechanism of chronic peritoneal dialysis patients. by Vlaanderen (1991)
10.1128/MCB.4.10.1999 / Mol Cell Biol / Cell surface expression of v-fms coded glycoproteins is required for transformation. by Roussel (1984)
10.1128/MCB.14.3.1669 / Mol Cell Biol / Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. by Resnitzky (1994)
10.1002/eji.1830090410 / Eur J Immunol / MAC1: A macrophage differentiation antigen identified by monoclonal antibody. by Springer (1979)
10.4049/jimmunol.130.1.108 / J Immunol / Expression and induction in vitro of macrophage differentiation antigens on murine cell lines. by Ralph (1983)
10.1093/intimm/3.2.205 / Int Immunol / Molecular and physiological properties of murine CD14. by Nasu (1991)
10.1002/eji.1830111013 / Eur J Immunol / F4/80, a monoclonal antibody directed specifically against the mouse macrophage. by Austyn (1981)
10.1128/MCB.9.11.5081 / Mol Cell Biol / Induction of macrophage colony-stimulating factor-dependent growth and differentiation after introduction of the murine c-fms gene into FDC-P1 cells. by Rohrschneider (1989)
10.1073/pnas.87.15.5613 / Proc Natl Acad Sci USA / Macrophage colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNA. by Pierce (1990)
10.1083/jcb.85.1.153 / J Cell Biol / Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells. by Guilbert (1980)
10.1083/jcb.91.3.848 / J Cell Biol / Distribution of cells bearing receptors for a colony-stimulating factor (CSF-1) in murine tissues. by Byrne (1981)
10.1016/S0021-9258(17)35616-8 / J Biol Chem / The interaction of 125I-colony-stimulating factor-1 with bone marrow-derived macrophages. by Guilbert (1986)
10.1182/blood.V75.1.1.bloodjournal7511 / Blood / Colony-stimulating factor-1 receptor. by Sherr (1990)
10.1128/MCB.9.9.4069 / Mol Cell Biol / Transduction of human colony stimulating factor-1 receptor into interleukin-3-dependent mouse myeloid cells induces both CSF-1-dependent and factor-independent growth. by Kato (1989)
10.1101/gad.9.10.1149 / Genes Dev / Inhibitors of mammalian G1 cyclin-dependent kinases. by Sherr (1995)
{'key': '2019112003383643200_B61', 'first-page': '3397', 'article-title': 'Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.', 'volume': '9', 'author': 'Jiang', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene / Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. by Jiang (1994)
{'key': '2019112003383643200_B62', 'first-page': '3389', 'article-title': 'Induction of p21(WAF-1/CIP1) during differentiation.', 'volume': '9', 'author': 'Steinman', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene / Induction of p21(WAF-1/CIP1) during differentiation. by Steinman (1994)
10.1126/science.7863329 / Science / p53-independent expression of p21CIP1 in muscle and other terminally differentiating cells. by Parker (1995)
10.1126/science.7863327 / Science / Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. by Halevy (1995)
10.1128/MCB.14.8.5259 / Mol Cell Biol / Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators. by Rao (1994)
10.1126/science.7863328 / Science / Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D-dependent kinase. by Skapek (1995)
10.1101/gad.9.6.650 / Genes Dev / p57KIP2, a structurally distinct member of the p21CIP1 cdk inhibitor family, is a candidate tumor suppressor gene. by Matsuoka (1995)
10.1091/mbc.7.10.1587 / Mol Biol Cell / Induction of p18ink4c and its predominant association with CDK4 and CDK6 during myogenic differentiation. by Franklin (1996)
10.1016/0092-8674(95)90039-X / Cell / Mice lacking p21Cip1/Waf1 undergo normal development, but are defective in G1 checkpoint control. by Deng (1995)
10.1016/S0092-8674(00)81079-X / Cell / Role of the INK4a locus in tumor suppression and cell mortality. by Serrano (1996)
10.1038/377552a0 / Nature / Radiation-induced cell cycle arrest compromised by p21 deficiency. by Brugarolas (1995)
10.1016/S0092-8674(00)81237-4 / Cell / Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. by Nakayama (1996)
10.1016/S0092-8674(00)81238-6 / Cell / Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. by Kiyokawa (1996)
10.1016/S0092-8674(00)81239-8 / Cell / A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27Kip1-deficient mice. by Fero (1996)
10.1126/science.8384376 / Science / Cyclin-dependent regulation of G1 in mammalian fibroblasts. by Ohtsubo (1993)
10.1126/science.272.5263.877 / Science / Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. by Coats (1996)
10.1074/jbc.271.31.18337 / J Biol Chem / Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0) state in fibroblasts. by Rivard (1996)
10.1101/gad.10.2.142 / Genes Dev / Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. by Liu (1996)
10.1128/MCB.15.10.5499 / Mol Cell Biol / The zinc finger transcription factor Egr-1 potentiates macrophage differentiation of hematopoietic cells. by Krishnaraju (1995)
10.1128/MCB.16.11.6457 / Mol Cell Biol / Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. by Hirai (1996)

Dates

Type	When
Created	5 years, 10 months ago (Oct. 13, 2019, 12:10 p.m.)
Deposited	1 year, 11 months ago (Sept. 21, 2023, 11:58 a.m.)
Indexed	1 month, 3 weeks ago (July 1, 2025, 9:50 a.m.)
Issued	28 years, 1 month ago (July 1, 1997)
Published	28 years, 1 month ago (July 1, 1997)
Published Print	28 years, 1 month ago (July 1, 1997)

Funders 0

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BibTeX

@article{Adachi_1997, title={Features of Macrophage Differentiation Induced by p19INK4d, a Specific Inhibitor of Cyclin D–Dependent Kinases}, volume={90}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood.v90.1.126.126_126_137}, DOI={10.1182/blood.v90.1.126.126_126_137}, number={1}, journal={Blood}, publisher={American Society of Hematology}, author={Adachi, Masashi and Roussel, Martine F. and Havenith, Karin and Sherr, Charles J.}, year={1997}, month=jul, pages={126–137} }

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  "abstract": "<jats:p>The mitogen-dependent induction of cyclin D\u2013dependent kinase activity is required for cells to enter the DNA synthetic (S) phase of their division cycle. Immature 32Dcl3 myeloid cells (32D) proliferating in the presence of interleukin-3 (IL-3) normally express cyclins D2 and D3, which assemble into binary holoenzyme complexes with their catalytic subunits, CDK4 and CDK6. When 32D cells are switched to medium containing granulocyte colony-stimulating factor (G-CSF ) instead of IL-3, D-type cyclins are degraded and, in the absence of their associated kinase activity, the cells arrest in the first gap phase (G1 ) of the cell cycle and differentiate to neutrophils. We derived 32D cells in which the expression of p19INK4d, a specific polypeptide inhibitor of CDK4 and CDK6, is regulated by the heavy metal-inducible sheep metallothionein promoter. Induction of p19INK4d in response to zinc prolonged cell survival in the absence of growth factor treatment. When maintained in medium containing both IL-3 and zinc, these cells lost cyclin D\u2013dependent kinase activity, underwent G1 phase arrest, and acquired certain morphologic, antigenic, and functional properties of mononuclear phagocytes. Cells induced to express p19INK4d did not synthesize receptors for macrophage colony-stimulating factor (M-CSF/CSF-1) and reverted to an immature myeloid phenotype when shifted back into medium containing IL-3 alone. These cells exhibited accelerated differentiation to neutrophils in response to G-CSF but also gave rise to macrophage-like cells when maintained in medium containing both G-CSF and zinc. Therefore, the acquisition of macrophage properties in response to zinc treatment neither depended upon IL-3 nor upon G1 phase arrest per se and instead reflects some ability of p19INK4d, and presumably cyclin D\u2013dependent kinases, to affect myeloid differentiation.</jats:p>",
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      "first-page": "503",
      "DOI": "10.1038/344503a0",
      "article-title": "Universal control mechanism regulating onset of M-phase.",
      "volume": "344",
      "author": "Nurse",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "2019112003383643200_B2",
      "doi-asserted-by": "crossref",
      "first-page": "1059",
      "DOI": "10.1016/0092-8674(93)90636-5",
      "article-title": "Mammalian G1 cyclins.",
      "volume": "73",
      "author": "Sherr",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "2019112003383643200_B3",
      "doi-asserted-by": "crossref",
      "first-page": "551",
      "DOI": "10.1016/0092-8674(94)90540-1",
      "article-title": "G1 phase progression: Cycling on cue.",
      "volume": "79",
      "author": "Sherr",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "2019112003383643200_B4",
      "doi-asserted-by": "crossref",
      "first-page": "323",
      "DOI": "10.1016/0092-8674(95)90385-2",
      "article-title": "The retinoblastoma protein and cell cycle control.",
      "volume": "81",
      "author": "Weinberg",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "2019112003383643200_B5",
      "doi-asserted-by": "crossref",
      "first-page": "424",
      "DOI": "10.1126/science.1411535",
      "article-title": "E2F: A link between the Rb tumor suppressor protein and viral oncoproteins.",
      "volume": "258",
      "author": "Nevins",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "2019112003383643200_B6",
      "doi-asserted-by": "crossref",
      "first-page": "108",
      "DOI": "10.1016/0968-0004(94)90202-X",
      "article-title": "DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell cycle control.",
      "volume": "19",
      "author": "La Thangue",
      "year": "1994",
      "journal-title": "Trends Biochem Sci"
    },
    {
      "key": "2019112003383643200_B7",
      "doi-asserted-by": "crossref",
      "first-page": "709",
      "DOI": "10.1073/pnas.91.2.709",
      "article-title": "Function of a human cyclin gene as an oncogene.",
      "volume": "91",
      "author": "Hinds",
      "year": "1994",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2019112003383643200_B8",
      "doi-asserted-by": "crossref",
      "first-page": "1759",
      "DOI": "10.1101/gad.8.15.1759",
      "article-title": "Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.",
      "volume": "8",
      "author": "Hatakeyama",
      "year": "1994",
      "journal-title": "Genes Dev"
    },
    {
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      "volume": "15",
      "author": "Ohtsubo",
      "year": "1995",
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      "author": "Pardee",
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      "journal-title": "Science"
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      "article-title": "Cancer cell cycles.",
      "volume": "274",
      "author": "Sherr",
      "year": "1996",
      "journal-title": "Science"
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      "volume": "7",
      "author": "Baldin",
      "year": "1993",
      "journal-title": "Genes Dev"
    },
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      "first-page": "1559",
      "DOI": "10.1101/gad.7.8.1559",
      "article-title": "Overexpression of mouse D-type cyclins accelerates G1 , phase in rodent fibroblasts.",
      "volume": "7",
      "author": "Quelle",
      "year": "1993",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2019112003383643200_B14",
      "doi-asserted-by": "crossref",
      "first-page": "2600",
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      "article-title": "Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells, independent of CDK4 activity.",
      "volume": "15",
      "author": "Lukas",
      "year": "1995",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2019112003383643200_B15",
      "doi-asserted-by": "crossref",
      "first-page": "701",
      "DOI": "10.1016/0092-8674(91)90101-4",
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      "author": "Ando",
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      "author": "Greenberger",
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      "author": "Valtieri",
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      "volume": "8",
      "author": "Downing",
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      "volume": "13",
      "author": "Vallance",
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      "author": "Matsushime",
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      "volume": "14",
      "author": "Meyerson",
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      "volume": "71",
      "author": "Matsushime",
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      "volume": "73",
      "author": "Ewen",
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      "volume": "130",
      "author": "Morgan",
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      "author": "Sherr",
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      "volume": "152",
      "author": "Furman",
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      "volume": "73",
      "author": "Ashmun",
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      "volume": "40",
      "author": "Rettenmier",
      "year": "1985",
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      "key": "2019112003383643200_B44",
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      "article-title": "Murine c-fms cDNA: Cloning, sequence analysis, and retroviral expression.",
      "volume": "1",
      "author": "Rothwell",
      "year": "1987",
      "journal-title": "Oncogene Res"
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      "key": "2019112003383643200_B45"
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      "key": "2019112003383643200_B46",
      "doi-asserted-by": "crossref",
      "first-page": "29",
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      "volume": "57",
      "author": "Vlaanderen",
      "year": "1991",
      "journal-title": "Nephron"
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      "first-page": "1999",
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      "article-title": "Cell surface expression of v-fms coded glycoproteins is required for transformation.",
      "volume": "4",
      "author": "Roussel",
      "year": "1984",
      "journal-title": "Mol Cell Biol"
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      "first-page": "1669",
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      "article-title": "Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.",
      "volume": "14",
      "author": "Resnitzky",
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      "first-page": "301",
      "DOI": "10.1002/eji.1830090410",
      "article-title": "MAC1: A macrophage differentiation antigen identified by monoclonal antibody.",
      "volume": "9",
      "author": "Springer",
      "year": "1979",
      "journal-title": "Eur J Immunol"
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    {
      "key": "2019112003383643200_B50",
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      "first-page": "108",
      "DOI": "10.4049/jimmunol.130.1.108",
      "article-title": "Expression and induction in vitro of macrophage differentiation antigens on murine cell lines.",
      "volume": "130",
      "author": "Ralph",
      "year": "1983",
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    {
      "key": "2019112003383643200_B51",
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      "first-page": "205",
      "DOI": "10.1093/intimm/3.2.205",
      "article-title": "Molecular and physiological properties of murine CD14.",
      "volume": "3",
      "author": "Nasu",
      "year": "1991",
      "journal-title": "Int Immunol"
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      "first-page": "805",
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      "volume": "11",
      "author": "Austyn",
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      "volume": "9",
      "author": "Rohrschneider",
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      "volume": "87",
      "author": "Pierce",
      "year": "1990",
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      "volume": "85",
      "author": "Guilbert",
      "year": "1980",
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      "volume": "91",
      "author": "Byrne",
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      "author": "Guilbert",
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      "volume": "9",
      "author": "Kato",
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      "author": "Jiang",
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      "author": "Parker",
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      "author": "Rao",
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      "author": "Skapek",
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      "volume": "9",
      "author": "Matsuoka",
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      "volume": "7",
      "author": "Franklin",
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      "volume": "82",
      "author": "Deng",
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      "author": "Serrano",
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      "first-page": "552",
      "DOI": "10.1038/377552a0",
      "article-title": "Radiation-induced cell cycle arrest compromised by p21 deficiency.",
      "volume": "377",
      "author": "Brugarolas",
      "year": "1995",
      "journal-title": "Nature"
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