DOI: 10.1182/blood.v84.7.2102.2102. Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling

Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling

10.1182/blood.v84.7.2102.2102

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract In this report we show that gamma-interferon (IFN) induces the expression of the nonreceptor protein tyrosine kinase, p72syk, and that cross-linking the Fc gamma RI receptor in IFN-differentiated U937 cells (U937IF cells) results in the activation of syk kinase. We show that syk is tyrosine phosphorylated (12-fold increase) after Fc gamma RI cross-linking. In vitro kinase assays demonstrate that the specific kinase activity of syk increased eightfold after Fc gamma RI cross- linking. The activation of signal transduction through the Fc gamma RI receptor, as measured by the respiratory burst, is associated with the tyrosine phosphorylation and catalytic activation of the syk kinase. We show that syk coprecipitates with the gamma subunit of the Fc gamma RI, Fc gamma RI gamma. The data suggest that p72syk is involved in signal transduction through the Fc gamma RI receptor, involving the Fc gamma RI gamma subunit.

Bibliography

Durden, D., & Liu, Y. (1994). Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling. Blood, 84(7), 2102â2108.

Authors 2

DL Durden (first)
YB Liu (additional)

References 0 Referenced 47

None

Dates

Type	When
Created	5 years, 10 months ago (Oct. 13, 2019, 10:30 p.m.)
Deposited	5 years, 9 months ago (Nov. 20, 2019, 4:48 a.m.)
Indexed	4 months, 4 weeks ago (March 30, 2025, 10:09 a.m.)
Issued	30 years, 10 months ago (Oct. 1, 1994)
Published	30 years, 10 months ago (Oct. 1, 1994)
Published Print	30 years, 10 months ago (Oct. 1, 1994)

Funders 0

None

BibTeX

@article{Durden_1994, title={Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling}, volume={84}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood.v84.7.2102.2102}, DOI={10.1182/blood.v84.7.2102.2102}, number={7}, journal={Blood}, publisher={American Society of Hematology}, author={Durden, DL and Liu, YB}, year={1994}, month=oct, pages={2102–2108} }

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