DOI: 10.1182/blood.v80.11.2891.2891. Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma

Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma

10.1182/blood.v80.11.2891.2891

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract In this study, the expression of the novel intermediate filament protein Restin in human tissues was analyzed. Restin expression was studied by immunohistochemistry using polyclonal and monoclonal antibodies. Restin was not detected in normal tissues, a range of B- and T-cell non-Hodgkin's lymphomas, and nonlymphoid tumors. However, Restin was present in Reed-Sternberg cells and variants thereof in Hodgkin's disease, with the exception of the lymphocyte-predominant, paragranuloma subtype. Restin was also highly expressed in anaplastic large-cell lymphoma (so-called Ki-1 lymphoma). As expected, Restin was also expressed in Hodgkin cell lines L428, L428KSA, Co, and KM-H2 and the anaplastic large-cell lymphoma cell line Karpas 299, which was confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting, as well as Northern blotting. The presence of Restin in both Hodgkin's disease and anaplastic large-cell lymphoma is intriguing and might indicate a role of this structural protein in the pathogenesis of both conditions.

Bibliography

Delabie, J., Shipman, R., Bruggen, J., De Strooper, B., van Leuven, F., Tarcsay, L., Cerletti, N., Odink, K., Diehl, V., & Bilbe, G. (1992). Expression of the novel intermediate filament-associated protein restin in Hodgkinâs disease and anaplastic large-cell lymphoma. Blood, 80(11), 2891â2896.

Authors 10

J Delabie (first)
R Shipman (additional)
J Bruggen (additional)
B De Strooper (additional)
F van Leuven (additional)
L Tarcsay (additional)
N Cerletti (additional)
K Odink (additional)
V Diehl (additional)
G Bilbe (additional)

References 0 Referenced 34

None

Dates

Type	When
Created	5 years, 10 months ago (Oct. 13, 2019, 5:40 p.m.)
Deposited	5 years, 9 months ago (Nov. 20, 2019, 1:11 a.m.)
Indexed	4 months, 2 weeks ago (April 8, 2025, 10:44 p.m.)
Issued	32 years, 8 months ago (Dec. 1, 1992)
Published	32 years, 8 months ago (Dec. 1, 1992)
Published Print	32 years, 8 months ago (Dec. 1, 1992)

Funders 0

None

BibTeX

@article{Delabie_1992, title={Expression of the novel intermediate filament-associated protein restin in Hodgkin’s disease and anaplastic large-cell lymphoma}, volume={80}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood.v80.11.2891.2891}, DOI={10.1182/blood.v80.11.2891.2891}, number={11}, journal={Blood}, publisher={American Society of Hematology}, author={Delabie, J and Shipman, R and Bruggen, J and De Strooper, B and van Leuven, F and Tarcsay, L and Cerletti, N and Odink, K and Diehl, V and Bilbe, G}, year={1992}, month=dec, pages={2891–2896} }

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