DOI: 10.1182/blood.v69.1.160.160. Selective expression of fos proto-oncogene in human acute myelomonocytic and monocytic leukemias: a molecular marker of terminal differentiation

Selective expression of fos proto-oncogene in human acute myelomonocytic and monocytic leukemias: a molecular marker of terminal differentiation

10.1182/blood.v69.1.160.160

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract Expression of human fos proto-oncogene (c-fos) was analyzed in primary cells from 50 untreated acute lymphocytic (ALL) and myeloblastic (AML) leukemias. c-fos RNA, analyzed by blot hybridization, was detected virtually only in myelomonocytic (M4) and monocytic (M5) AML. Both M4 and M5 samples show a strong positive correlation between the amount of c-fos transcripts and the percentage of leukemic cells expressing surface antigens specific for mature monocytes and macrophages. Normal mature monocytes exhibit a detectable level of c-fos RNA, which is virtually unaltered on activation to macrophage differentiation, but is always below that observed in M4 through M5 monocyticlike cells. These data provide evidence that c-fos expression is linked to terminal monocyte and macrophage differentiation in normal and leukemic hemopoiesis.

Bibliography

Mavilio, F., Testa, U., Sposi, N., Petrini, M., Pelosi, E., Bordignon, C., Amadori, S., Mandelli, F., & Peschle, C. (1987). Selective expression of fos proto-oncogene in human acute myelomonocytic and monocytic leukemias: a molecular marker of terminal differentiation. Blood, 69(1), 160â164.

Authors 9

F Mavilio (first)
U Testa (additional)
NM Sposi (additional)
M Petrini (additional)
E Pelosi (additional)
C Bordignon (additional)
S Amadori (additional)
F Mandelli (additional)
C Peschle (additional)

References 0 Referenced 15

None

Dates

Type	When
Created	5 years, 10 months ago (Oct. 13, 2019, 4:33 a.m.)
Deposited	5 years, 9 months ago (Nov. 19, 2019, 3:54 p.m.)
Indexed	1 year, 9 months ago (Nov. 20, 2023, 11:12 p.m.)
Issued	38 years, 8 months ago (Jan. 1, 1987)
Published	38 years, 8 months ago (Jan. 1, 1987)
Published Print	38 years, 8 months ago (Jan. 1, 1987)

Funders 0

None

BibTeX

@article{Mavilio_1987, title={Selective expression of fos proto-oncogene in human acute myelomonocytic and monocytic leukemias: a molecular marker of terminal differentiation}, volume={69}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood.v69.1.160.160}, DOI={10.1182/blood.v69.1.160.160}, number={1}, journal={Blood}, publisher={American Society of Hematology}, author={Mavilio, F and Testa, U and Sposi, NM and Petrini, M and Pelosi, E and Bordignon, C and Amadori, S and Mandelli, F and Peschle, C}, year={1987}, month=jan, pages={160–164} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2023,
        11,
        21
      ]
    ],
    "date-time": "2023-11-21T04:12:24Z",
    "timestamp": 1700539944355
  },
  "reference-count": 0,
  "publisher": "American Society of Hematology",
  "issue": "1",
  "content-domain": {
    "domain": [
      "ashpublications.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1987,
        1,
        1
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>Expression of human fos proto-oncogene (c-fos) was analyzed in primary cells from 50 untreated acute lymphocytic (ALL) and myeloblastic (AML) leukemias. c-fos RNA, analyzed by blot hybridization, was detected virtually only in myelomonocytic (M4) and monocytic (M5) AML. Both M4 and M5 samples show a strong positive correlation between the amount of c-fos transcripts and the percentage of leukemic cells expressing surface antigens specific for mature monocytes and macrophages. Normal mature monocytes exhibit a detectable level of c-fos RNA, which is virtually unaltered on activation to macrophage differentiation, but is always below that observed in M4 through M5 monocyticlike cells. These data provide evidence that c-fos expression is linked to terminal monocyte and macrophage differentiation in normal and leukemic hemopoiesis.</jats:p>",
  "DOI": "10.1182/blood.v69.1.160.160",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2019,
        10,
        13
      ]
    ],
    "date-time": "2019-10-13T08:33:17Z",
    "timestamp": 1570955597000
  },
  "page": "160-164",
  "update-policy": "http://dx.doi.org/10.1182/blood.2019cm0000",
  "source": "Crossref",
  "is-referenced-by-count": 15,
  "title": "Selective expression of fos proto-oncogene in human acute myelomonocytic and monocytic leukemias: a molecular marker of terminal differentiation",
  "prefix": "10.1182",
  "volume": "69",
  "author": [
    {
      "given": "F",
      "family": "Mavilio",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "U",
      "family": "Testa",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "NM",
      "family": "Sposi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M",
      "family": "Petrini",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "E",
      "family": "Pelosi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "C",
      "family": "Bordignon",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S",
      "family": "Amadori",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "F",
      "family": "Mandelli",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "C",
      "family": "Peschle",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "234",
  "container-title": "Blood",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://ashpublications.org/blood/article-pdf/69/1/160/596119/160.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "http://ashpublications.org/blood/article-pdf/69/1/160/596119/160.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        11,
        19
      ]
    ],
    "date-time": "2019-11-19T20:54:51Z",
    "timestamp": 1574196891000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://ashpublications.org/blood/article/69/1/160/165449/Selective-expression-of-fos-protooncogene-in-human"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1987,
        1,
        1
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1987,
          1,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1182/blood.V69.1.160.160",
  "relation": {},
  "ISSN": [
    "0006-4971",
    "1528-0020"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1987,
        1,
        1
      ]
    ]
  }
}