DOI: 10.1182/blood.v60.5.1231.1231. Thrombin-induced secretion of serotonin from platelets can occur in seconds

Thrombin-induced secretion of serotonin from platelets can occur in seconds

10.1182/blood.v60.5.1231.1231

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract The platelet release reaction was studied by a new quenched-flow approach. Platelets labeled with 14C-serotonin were reacted for short times (up to 5 sec) with thrombin and then quenched with glutaraldehyde or paraformaldehyde. Serotonin secretion began within 1 sec and was nearly complete by 4 sec. Aggregation recorded by a resistive-particle counter was similarly fast. Therefore, the quenched-flow system reveals that serotonin secretion can occur more rapidly than estimated in earlier studies.

Bibliography

Gear, A., & Burke, D. (1982). Thrombin-induced secretion of serotonin from platelets can occur in seconds. Blood, 60(5), 1231â1234.

Authors 2

AR Gear (first)
D Burke (additional)

References 0 Referenced 24

None

Dates

Type	When
Created	5 years, 10 months ago (Oct. 13, 2019, 1:33 a.m.)
Deposited	5 years, 9 months ago (Nov. 19, 2019, 4:17 p.m.)
Indexed	1 day, 16 hours ago (Sept. 4, 2025, 10:13 a.m.)
Issued	42 years, 10 months ago (Nov. 1, 1982)
Published	42 years, 10 months ago (Nov. 1, 1982)
Published Print	42 years, 10 months ago (Nov. 1, 1982)

Funders 0

None

BibTeX

@article{Gear_1982, title={Thrombin-induced secretion of serotonin from platelets can occur in seconds}, volume={60}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood.v60.5.1231.1231}, DOI={10.1182/blood.v60.5.1231.1231}, number={5}, journal={Blood}, publisher={American Society of Hematology}, author={Gear, AR and Burke, D}, year={1982}, month=nov, pages={1231–1234} }

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