DOI: 10.1182/blood.v54.6.1272.1272. Activated protein C inhibits platelet prothrombin-converting activity

Activated protein C inhibits platelet prothrombin-converting activity

10.1182/blood.v54.6.1272.1272

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract Bovine platelets that have been activated by thrombin facilitate the conversion of prothrombin to thrombin in the presence of calcium ions and factor Xa. Activated protein C, a vitamin-K-dependent plasma protein, inhibits this platelet prothrombin-converting activity. The inhibition is time dependent and is not reversed by increasing concentrations of factor Xa. However, factor Xa is able to protect the platelet prothrombin-converting activity from inactivation by activated protein C. The activated protein C causes a parallel loss of factor Xa receptor sites and platelet prothrombin-converting activity. Activated protein C may contribute to the regulation of clotting through inactivation of the platelet prothrombin-converting activity.

Bibliography

Comp, P., & Esmon, C. (1979). Activated protein C inhibits platelet prothrombin-converting activity. Blood, 54(6), 1272â1281.

Authors 2

PC Comp (first)
CT Esmon (additional)

References 0 Referenced 59

None

Dates

Type	When
Created	5 years, 10 months ago (Oct. 13, 2019, 2:44 a.m.)
Deposited	5 years, 9 months ago (Nov. 19, 2019, 3:09 p.m.)
Indexed	11 months, 2 weeks ago (Sept. 10, 2024, 7:07 p.m.)
Issued	45 years, 8 months ago (Dec. 1, 1979)
Published	45 years, 8 months ago (Dec. 1, 1979)
Published Print	45 years, 8 months ago (Dec. 1, 1979)

Funders 0

None

BibTeX

@article{Comp_1979, title={Activated protein C inhibits platelet prothrombin-converting activity}, volume={54}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood.v54.6.1272.1272}, DOI={10.1182/blood.v54.6.1272.1272}, number={6}, journal={Blood}, publisher={American Society of Hematology}, author={Comp, PC and Esmon, CT}, year={1979}, month=dec, pages={1272–1281} }

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