DOI: 10.1182/blood.v54.1.8.8. Release of platelet fibronectin (cold-insoluble globulin) from alpha granules induced by thrombin or collagen; lack of requirement for plasma fibronectin in ADP-induced platelet aggregation

Release of platelet fibronectin (cold-insoluble globulin) from alpha granules induced by thrombin or collagen; lack of requirement for plasma fibronectin in ADP-induced platelet aggregation

10.1182/blood.v54.1.8.8

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract Platelets lysed with Triton X-100 contain 3.44 +/- 1.27 (SD) microgram of fibronectin (cold-insoluble globulin) per 10(9) platelets. Fibronectin was partially released from washed whole platelets by collagen or thrombin, and its release by collagen was inhibited by aspirin. Analysis of subcellular fractions obtained by density-gradient centrifugation of disrupted platelets indicated that fibronectin was contained in the alpha granules. Fibrinogen depleted of fibronectin (less than 2 microgram/mg) supported ADP-induced aggregation as effectively as fibrinogen contaminated with this protein, thus reinforcing the generally held view that fibrinogen itself is the necessary protein cofactor in this reaction.

Bibliography

Zucker, M., Mosesson, M., Broekman, M., & Kaplan, K. (1979). Release of platelet fibronectin (cold-insoluble globulin) from alpha granules induced by thrombin or collagen; lack of requirement for plasma fibronectin in ADP-induced platelet aggregation. Blood, 54(1), 8â12.

Authors 4

MB Zucker (first)
MW Mosesson (additional)
MJ Broekman (additional)
KL Kaplan (additional)

References 0 Referenced 101

None

Dates

Type	When
Created	5 years, 10 months ago (Oct. 13, 2019, 1:07 a.m.)
Deposited	5 years, 9 months ago (Nov. 19, 2019, 2:47 p.m.)
Indexed	1 year, 3 months ago (May 12, 2024, 4:01 p.m.)
Issued	46 years, 2 months ago (July 1, 1979)
Published	46 years, 2 months ago (July 1, 1979)
Published Print	46 years, 2 months ago (July 1, 1979)

Funders 0

None

BibTeX

@article{Zucker_1979, title={Release of platelet fibronectin (cold-insoluble globulin) from alpha granules induced by thrombin or collagen; lack of requirement for plasma fibronectin in ADP-induced platelet aggregation}, volume={54}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood.v54.1.8.8}, DOI={10.1182/blood.v54.1.8.8}, number={1}, journal={Blood}, publisher={American Society of Hematology}, author={Zucker, MB and Mosesson, MW and Broekman, MJ and Kaplan, KL}, year={1979}, month=jul, pages={8–12} }

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