DOI: 10.1182/blood.v40.2.239.239. A Family of Congenital Atransferrinemia

10.1182/blood.v40.2.239.239

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract An 8-yr-old boy with familial congenital atransferrinemia was studied. He had marked hypochromic anemia but did not respond to administration of iron. The patient responded favorably to parenteral "Eisen-mangel" human serum transferrin. One gram of transferrin was infused intravenously; it disappeared almost completely from the serum within a week. However, the hemoglobin and erythrocytes increased, and there was general improvement in the color and activity of the patient. After 3-6 mo, his clinical picture had returned to that seen prior to treatment. Thus, it appeared that the hemopoiesis was stimulated by transferrin and that the clinical effectiveness of transferrin was related to the resultant increased red cell production and the duration of the effect to the life-span of the erythrocyte. Neither side effects nor reduction in the effectiveness of transferrin administration was noticed during a year and a half of treatment.

Bibliography

Goya, N., Miyazaki, S., Kodate, S., & Ushio, B. (1972). A Family of Congenital Atransferrinemia. Blood, 40(2), 239â245.

Authors 4

Nagahide Goya (first)
Sumio Miyazaki (additional)
Saburo Kodate (additional)
Bunichi Ushio (additional)

References 0 Referenced 139

None

Dates

Type	When
Created	5 years, 10 months ago (Oct. 12, 2019, 8:55 a.m.)
Deposited	5 years, 9 months ago (Nov. 19, 2019, 2:15 p.m.)
Indexed	2 months, 2 weeks ago (June 10, 2025, 1:28 p.m.)
Issued	53 years ago (Aug. 1, 1972)
Published	53 years ago (Aug. 1, 1972)
Published Print	53 years ago (Aug. 1, 1972)

Funders 0

None

BibTeX

@article{Goya_1972, title={A Family of Congenital Atransferrinemia}, volume={40}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood.v40.2.239.239}, DOI={10.1182/blood.v40.2.239.239}, number={2}, journal={Blood}, publisher={American Society of Hematology}, author={Goya, Nagahide and Miyazaki, Sumio and Kodate, Saburo and Ushio, Bunichi}, year={1972}, month=aug, pages={239–245} }

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