DOI: 10.1182/blood.v35.3.350.350. Improvement of Leukocyte Bactericidal Activity in Chronic Granulomatous Disease

Improvement of Leukocyte Bactericidal Activity in Chronic Granulomatous Disease

10.1182/blood.v35.3.350.350

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract Chronic granulomatous disease (CGD) is characterized by an inability of patients’ leukocytes to generate hydrogen peroxide and to kill non-peroxide-forming bacteria, such as staphylococci and serratiae. We have introduced glucose oxidase into CGD leukocytes in order to generate peroxide and thereby kill S. aureus and S. marcescens. These results support the concept that a leukocyte oxidative deficiency is primary to the pathogenesis of CGD.

Bibliography

JOHNSTON, R. B., & BAEHNER, R. L. (1970). Improvement of Leukocyte Bactericidal Activity in Chronic Granulomatous Disease. Blood, 35(3), 350â355.

Authors 2

RICHARD B. JOHNSTON (first)
ROBERT L. BAEHNER (additional)

References 0 Referenced 48

None

Dates

Type	When
Created	5 years, 10 months ago (Oct. 12, 2019, 8:04 a.m.)
Deposited	5 years, 9 months ago (Nov. 19, 2019, 1:42 p.m.)
Indexed	11 months, 4 weeks ago (Sept. 4, 2024, 7:49 p.m.)
Issued	55 years, 6 months ago (March 1, 1970)
Published	55 years, 6 months ago (March 1, 1970)
Published Print	55 years, 6 months ago (March 1, 1970)

Funders 0

None

JSON

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