DOI: 10.1182/blood-2005-03-1239. Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

10.1182/blood-2005-03-1239

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

AbstractDectin-1 is a lectin receptor for β-glucan that is important for innate macrophage recognition of fungi and contributes to phagocytosis, reactive oxygen production, and induction of inflammatory cytokines. The mechanisms by which Dectin-1 mediates intracellular signaling are just beginning to be defined. Spleen tyrosine kinase (Syk) is a protein tyrosine kinase that is critical for adaptive immune responses where it mediates signaling through B-cell receptors, T-cell receptors, and Fc receptors. Here we report that Dectin-1 activates Syk in macrophages and is important for Dectin-1-stimulated reactive oxygen production, but not for phagocytosis. Syk activation is restricted to a subpopulation of macrophages that is in equilibrium with cells that cannot activate the pathway. The proportion of macrophages using this signaling pathway can be modulated by cytokine treatment. Thus, Dectin-1 signaling reveals dynamic macrophage heterogeneity in inflammatory activation potential. (Blood. 2005;106:2543-2550)

Bibliography

Underhill, D. M., Rossnagle, E., Lowell, C. A., & Simmons, R. M. (2005). Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood, 106(7), 2543â2550.

Authors 4

David M. Underhill (first)
Eddie Rossnagle (additional)
Clifford A. Lowell (additional)
Randi M. Simmons (additional)

References 39 Referenced 413

Dates

Type	When
Created	20 years, 2 months ago (June 15, 2005, 12:04 a.m.)
Deposited	2 years, 4 months ago (May 3, 2023, 7:23 a.m.)
Indexed	2 days, 7 hours ago (Sept. 3, 2025, 6:21 a.m.)
Issued	19 years, 11 months ago (Oct. 1, 2005)
Published	19 years, 11 months ago (Oct. 1, 2005)
Published Print	19 years, 11 months ago (Oct. 1, 2005)

Funders 0

None

BibTeX

@article{Underhill_2005, title={Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production}, volume={106}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood-2005-03-1239}, DOI={10.1182/blood-2005-03-1239}, number={7}, journal={Blood}, publisher={American Society of Hematology}, author={Underhill, David M. and Rossnagle, Eddie and Lowell, Clifford A. and Simmons, Randi M.}, year={2005}, month=oct, pages={2543–2550} }

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