DOI: 10.1182/blood-2005-03-1159. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS

Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS

10.1182/blood-2005-03-1159

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

Abstract Hepatic peptide hormone hepcidin is the key regulator of iron metabolism and the mediator of anemia of inflammation. Previous studies indicated that interleukin-6 (IL-6) mediates hepcidin increase and consequent hypoferremia during inflammation. Here we used an in vivo human endotoxemia model to analyze the effects of lipopolysaccharide (LPS) as a more upstream inflammation activator. The temporal associations between plasma cytokines, hepcidin levels, and serum iron parameters were studied in 10 healthy individuals after LPS injection. IL-6 was dramatically induced within 3 hours after injection, and urinary hepcidin peaked within 6 hours, followed by a significant decrease in serum iron. Serum prohepcidin showed no significant change within a 22-hour time frame. These in vivo human results confirm the importance of the IL-6-hepcidin axis in the development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system. (Blood. 2005;106: 1864-1866)

Bibliography

Kemna, E., Pickkers, P., Nemeth, E., van der Hoeven, H., & Swinkels, D. (2005). Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood, 106(5), 1864â1866.

Authors 5

Erwin Kemna (first)
Peter Pickkers (additional)
Elizabeta Nemeth (additional)
Hans van der Hoeven (additional)
Dorine Swinkels (additional)

References 16 Referenced 361

Dates

Type	When
Created	20 years, 3 months ago (May 10, 2005, 10:14 p.m.)
Deposited	5 years, 6 months ago (Feb. 12, 2020, 8:52 p.m.)
Indexed	1 month ago (Aug. 6, 2025, 8:21 a.m.)
Issued	20 years ago (Sept. 1, 2005)
Published	20 years ago (Sept. 1, 2005)
Published Print	20 years ago (Sept. 1, 2005)

Funders 0

None

BibTeX

@article{Kemna_2005, title={Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS}, volume={106}, ISSN={1528-0020}, url={http://dx.doi.org/10.1182/blood-2005-03-1159}, DOI={10.1182/blood-2005-03-1159}, number={5}, journal={Blood}, publisher={American Society of Hematology}, author={Kemna, Erwin and Pickkers, Peter and Nemeth, Elizabeta and van der Hoeven, Hans and Swinkels, Dorine}, year={2005}, month=sep, pages={1864–1866} }

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