DOI: 10.1182/blood-2002-04-1197. Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants

Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants

10.1182/blood-2002-04-1197

Crossref journal-article

American Society of Hematology

Blood (234)

Abstract

One of the functions of HLA class I alleles is interaction with natural killer (NK) cells. Receptors termed killer immunoglobulinlike receptors (KIRs) on NK cells recognize groups of HLA class I alleles, and interaction between receptor and class I allele inhibits reactivity of the NK cell. Failure to recognize the appropriate KIR ligand on a mismatched cell can trigger NK cell elimination of that target cell. Recent analysis of haploidentical hematopoietic transplantations has shown a reduction of graft failure, graft-versus-host disease, and relapse in those with KIR ligand incompatibility in the graft-versus-host direction. In this study we analyzed the effect of KIR ligand incompatibility on outcomes of unrelated donor bone marrow transplantations. The data show no advantage for KIR ligand incompatibility in this clinical setting as assessed by HLA-Bw4 and HLA-C alleles. It is possible that there will be a benefit of NK cell alloreactivity if strategies of haploidentical transplantation are used: high stem cell doses, extensive T-cell depletion, and no postgrafting immune suppression.

Bibliography

Davies, S. M., Ruggieri, L., DeFor, T., Wagner, J. E., Weisdorf, D. J., Miller, J. S., Velardi, A., & Blazar, B. R. (2002). Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Blood, 100(10), 3825â3827.

Authors 8

Stella M. Davies (first)
Loredana Ruggieri (additional)
Todd DeFor (additional)
John E. Wagner (additional)
Daniel J. Weisdorf (additional)
Jeffrey S. Miller (additional)
Andrea Velardi (additional)
Bruce R. Blazar (additional)

References 13 Referenced 310

10.1038/319675a0 / Nature. / Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defense strategy. by Karre (1986)
10.1126/science.2814488 / Science. / Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice. by Ohlen (1989)
10.1126/science.1068440 / Science. / Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. by Ruggeri (2002)
10.1097/00007890-197410000-00001 / Transplantation. / Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA matched sibling donors. by Glucksberg (1974)
10.1002/(SICI)1097-0258(19970430)16:8<901::AID-SIM543>3.0.CO;2-M / Stat Med. / Non-parametric inference for cumulative incidence functions in competing risks studies. by Lin (1997)
10.1080/01621459.1958.10501452 / J Am Stat Assoc. / Nonparametric estimation from incomplete observations. by Kaplan (1958)
10.1111/j.2517-6161.1972.tb00899.x / J Royal Soc B. / Regression models and life tables. by Cox (1972)
10.1182/blood.V84.11.3948.bloodjournal84113948 / Blood. / Successful engraftment of T-cell-depleted haploidentical “three-loci” incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. by Aversa (1994)
10.1038/nm1295-1268 / Nat Med. / Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice. by Bachar-Lustig (1995)
10.1056/NEJM199810223391702 / N Engl J Med. / Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. by Aversa (1998)
10.1182/blood.V75.6.1370.1370 / Blood. / Bone marrow graft engineering by counterflow centrifugal elutriation: results of a phase I-II clinical trial. by Wagner (1990)
10.1016/S1074-7613(00)80393-3 / Immunity. / Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. by Valiante (1997)
10.1016/S1074-7613(00)80394-5 / Immunity. / Human diversity in killer cell inhibitory receptor genes. by Uhrberg (1997)

Dates

Type	When
Created	22 years, 9 months ago (Oct. 30, 2002, 2:43 p.m.)
Deposited	8 months, 2 weeks ago (Dec. 10, 2024, 5:37 p.m.)
Indexed	6 days, 20 hours ago (Aug. 23, 2025, 12:59 a.m.)
Issued	22 years, 9 months ago (Nov. 15, 2002)
Published	22 years, 9 months ago (Nov. 15, 2002)
Published Print	22 years, 9 months ago (Nov. 15, 2002)

Funders 0

None

BibTeX

@article{Davies_2002, title={Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants}, volume={100}, ISSN={0006-4971}, url={http://dx.doi.org/10.1182/blood-2002-04-1197}, DOI={10.1182/blood-2002-04-1197}, number={10}, journal={Blood}, publisher={American Society of Hematology}, author={Davies, Stella M. and Ruggieri, Loredana and DeFor, Todd and Wagner, John E. and Weisdorf, Daniel J. and Miller, Jeffrey S. and Velardi, Andrea and Blazar, Bruce R.}, year={2002}, month=nov, pages={3825–3827} }

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