DOI: 10.1177/17.5.303. THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

10.1177/17.5.303

Crossref journal-article

SAGE Publications

Journal of Histochemistry & Cytochemistry (179)

Abstract

A group of apparently unrelated endocrine cells, some in endocrine glands, others in nonendocrine tissues, share a number of cytochemical and ultrastructural characteristics. These characteristics, from the initial letters of four of which the term APUD is derived, indicate the possession of a common metabolic pattern and common synthetic, storage and secretion mechanisms. It is postulated that the various characteristics reflect the production and storage of hormone precursor protein which has a predominantly random coil conformation. Several explanations are possible to account for the APUD characteristics but if the cells, in fact, share a common ancestor the only possible candidate is the neural crest cell.

Bibliography

PEARSE, A. G. E. (1969). THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT. Journal of Histochemistry & Cytochemistry, 17(5), 303â313.

Authors 1

A. G. E. PEARSE (first)

References 0 Referenced 1,290

None

Dates

Type	When
Created	14 years, 4 months ago (April 1, 2011, 12:54 a.m.)
Deposited	5 months, 4 weeks ago (March 2, 2025, 2:43 p.m.)
Indexed	1 day, 9 hours ago (Aug. 30, 2025, 1 p.m.)
Issued	56 years, 3 months ago (May 1, 1969)
Published	56 years, 3 months ago (May 1, 1969)
Published Online	56 years, 3 months ago (May 1, 1969)
Published Print	56 years, 3 months ago (May 1, 1969)

Funders 0

None

BibTeX

@article{PEARSE_1969, title={THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT}, volume={17}, ISSN={1551-5044}, url={http://dx.doi.org/10.1177/17.5.303}, DOI={10.1177/17.5.303}, number={5}, journal={Journal of Histochemistry & Cytochemistry}, publisher={SAGE Publications}, author={PEARSE, A. G. E.}, year={1969}, month=may, pages={303–313} }

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