DOI: 10.1177/135965350701200s03.1. Respiratory Syncytial Virus Infection in Adults

Respiratory Syncytial Virus Infection in Adults

10.1177/135965350701200s03.1

Crossref journal-article

SAGE Publications

Antiviral Therapy (179)

Abstract

Originally considered as only a paediatric pathogen, respiratory syncytial virus (RSV) has recently been shown to be a significant cause of respiratory illness among elderly and high-risk adults. Approximately 170,000 hospitalizations and 10,000 deaths associated with RSV occur annually in people over the age of 65 years in the United States. Although rhinorrhoea and wheezing are common symptoms among adults, the clinical syndrome associated with RSV is not distinctive and thus laboratory methods are required for specific diagnosis. Presently, the combination of reverse transcription PCR and enzyme immunoassay serology offers the best sensitivity and specificity for diagnosis of RSV. Treatment options are limited at present, with inhaled ribavirin being the only licensed drug for use in hospitalized children. Vaccines against RSV remain an unachieved goal. Promising new agents that inhibit the virus-cell fusion, cell-cell fusion, or viral gene expression are currently in development.

Bibliography

Murata, Y., & Falsey, A. R. (2007). Respiratory Syncytial Virus Infection in Adults. Antiviral Therapy, 12(4_part_2), 659â670.

Authors 2

Yoshihiko Murata (first)
Ann R Falsey (additional)

References 122 Referenced 40

{'key': 'bibr1-135965350701200S03.1', 'first-page': '281', 'volume': '66', 'author': 'Chanock R.', 'year': '1957', 'journal-title': 'Am J Hyg'} / Am J Hyg by Chanock R. (1957)
10.7326/0003-4819-109-3-203
10.1056/NEJMoa043951
10.1001/jama.289.2.179
10.1007/978-1-4615-3790-8_4
10.1073/pnas.84.16.5625
10.1093/infdis/155.6.1198
10.1128/CMR.13.3.371
10.1016/j.vaccine.2006.09.041
10.1001/archinte.162.11.1229
10.1136/bmj.281.6250.1253-a
{'key': 'bibr12-135965350701200S03.1', 'first-page': '351', 'volume': '26', 'author': 'Center for Disease Control.', 'year': '1977', 'journal-title': 'MMWR'} / MMWR by Center for Disease Control. (1977)
10.1111/j.1532-5415.1995.tb06238.x
10.1136/bmj.315.7115.1060
10.1016/S0140-6736(01)06528-X
10.1093/infdis/174.3.456
10.1164/ajrccm.160.3.9901004
10.1016/S0140-6736(63)90894-8
10.1056/NEJM196401162700303
10.1136/thorax.58.1.37
10.1164/ajrccm.164.9.2105011
Rohde G., Borg I., Arinir U. The role of RSV in respiratory infections in adults. 101st International Meeting of the American Thoracic Society. 23 May 2005, San Diego, USA. Poster J77.
10.1183/09031936.03.00088102
10.1164/rccm.200509-1489OC
10.1164/rccm.200510-1681OC
10.1111/j.1532-5415.1992.tb01929.x
10.1086/511986
10.1111/j.1532-5415.1995.tb06384.x
10.7326/0003-4819-93-1-49
10.1016/S0163-4453(84)90530-9
10.1016/S1386-6532(02)00084-7
10.1128/jcm.34.7.1649-1653.1996
10.7326/0003-4819-88-2-203
10.1111/j.1532-5415.1996.tb05641.x
{'key': 'bibr35-135965350701200S03.1', 'first-page': '451', 'volume': '115', 'author': 'Kellogg J.A.', 'year': '1991', 'journal-title': 'Arch Pathol Lab Med'} / Arch Pathol Lab Med by Kellogg J.A. (1991)
10.1128/JCM.42.7.2996-2999.2004
10.1016/S1386-6532(03)00002-7
10.1128/JCM.44.3.1105-1107.2006
10.1128/JCM.40.3.817-820.2002
10.1086/516284 / Clin Infect Dis by Fan J. (1998)
{'key': 'bibr41-135965350701200S03.1', 'first-page': '13', 'volume': '21', 'author': 'Freymuth', 'year': '2000', 'journal-title': 'Rev Mal Respir'} / Rev Mal Respir by Freymuth (2000)
10.1128/JCM.41.9.4160-4165.2003
10.1007/S10096-006-0112-4
10.1128/jcm.28.12.2744-2749.1990
10.1128/jcm.26.5.808-811.1988
10.1586/14787210.3.6.945
10.1097/01.inf.0000053892.99856.ef
10.1056/NEJM198306163082403
10.1001/archpedi.153.5.469
10.1378/chest.93.6.1239
10.1016/S0022-5223(94)70168-7
10.1016/S0022-3476(05)80554-2
10.1016/j.antiviral.2005.06.009
10.1016/j.antiviral.2003.07.002
10.1016/S0166-3542(98)00002-3
10.1128/AAC.48.7.2448-2454.2004
10.1128/AAC.48.2.413-422.2004
10.1128/AAC.46.3.841-847.2002
10.1016/j.antiviral.2003.07.004
10.1099/0022-1317-65-4-761
10.1006/viro.1994.1245
10.1073/pnas.94.25.13961
10.1128/JVI.73.8.6610-6617.1999
10.1128/AAC.35.12.2515
10.1093/jac/dkh355
10.1016/S0166-3542(96)01019-4
10.1016/S0166-3542(03)00009-3
10.1128/JVI.79.20.13105-13115.2005
10.1016/j.antiviral.2004.12.002
10.1016/j.coph.2005.05.003
10.1002/rmv.423
10.1016/j.antiviral.2003.10.005
10.1126/science.1069132
10.1038/nm1164
10.1038/nm1174
10.1016/0166-3542(93)90065-Q
10.1016/j.antiviral.2005.09.003
10.1056/NEJM199311183292102
{'key': 'bibr79-135965350701200S03.1', 'first-page': '463', 'volume': '95', 'author': 'Groothuis J.R.', 'year': '1995', 'journal-title': 'Pediatrics'} / Pediatrics by Groothuis J.R. (1995)
10.1542/peds.102.3.531
10.1086/322043
10.1038/sj.bmt.1702228
10.1086/380907
10.1002/jmv.20090
10.1086/421524
10.1093/oxfordjournals.aje.a120956
10.1093/oxfordjournals.aje.a120955
10.1093/oxfordjournals.aje.a120957
10.1016/S0264-410X(96)00030-8
10.1016/S0264-410X(97)00002-9
10.1016/S0264-410X(03)00352-9
10.1086/324426
10.1086/514138
10.1016/S0264-410X(98)00381-8
10.1128/JVI.73.2.871-877.1999
10.1086/315859
10.1016/S0264-410X(99)00527-7
10.1006/viro.2002.1431
10.1128/JVI.76.11.5654-5666.2002
10.1016/0264-410X(93)90284-5
10.1128/CMR.18.3.541-555.2005
10.1016/0264-410X(91)90151-U
10.1203/00006450-199308000-00013
10.1513/pats.200503-022AW
10.1172/JCI115362
10.1513/pats.200501-002AW
10.1111/j.1365-2249.1992.tb06482.x
10.1172/JCI119391
10.1099/0022-1317-77-10-2447
10.1002/eji.1830271233
10.3181/00379727-157-40112
10.3181/00379727-160-40433
10.1128/JVI.73.12.10086-10094.1999
10.1128/JVI.72.5.4080-4087.1998
10.1016/0264-410X(90)90253-I
10.1093/intimm/4.4.493
10.1097/01.inf.0000078165.62923.15
10.1211/jpp.57.11.0001
10.1128/AAC.49.11.4700-4707.2005
10.1093/infdis/141.1.98
10.1016/S0022-3476(81)80969-9
10.1016/0140-6736(92)93088-5

Dates

Type	When
Created	3 years, 4 months ago (April 14, 2022, noon)
Deposited	5 months, 3 weeks ago (March 1, 2025, 5:09 p.m.)
Indexed	4 months, 1 week ago (April 11, 2025, 7:52 a.m.)
Issued	18 years, 7 months ago (Jan. 1, 2007)
Published	18 years, 7 months ago (Jan. 1, 2007)
Published Online	18 years, 7 months ago (Jan. 1, 2007)
Published Print	18 years, 7 months ago (Jan. 1, 2007)

Funders 0

None

BibTeX

@article{Murata_2007, title={Respiratory Syncytial Virus Infection in Adults}, volume={12}, ISSN={2040-2058}, url={http://dx.doi.org/10.1177/135965350701200s03.1}, DOI={10.1177/135965350701200s03.1}, number={4_part_2}, journal={Antiviral Therapy}, publisher={SAGE Publications}, author={Murata, Yoshihiko and Falsey, Ann R}, year={2007}, month=jan, pages={659–670} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        11
      ]
    ],
    "date-time": "2025-04-11T11:52:10Z",
    "timestamp": 1744372330989,
    "version": "3.38.0"
  },
  "reference-count": 122,
  "publisher": "SAGE Publications",
  "issue": "4_part_2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2007,
            1,
            1
          ]
        ],
        "date-time": "2007-01-01T00:00:00Z",
        "timestamp": 1167609600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://journals.sagepub.com/page/policies/text-and-data-mining-license"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        1
      ]
    ]
  },
  "abstract": "<jats:p> Originally considered as only a paediatric pathogen, respiratory syncytial virus (RSV) has recently been shown to be a significant cause of respiratory illness among elderly and high-risk adults. Approximately 170,000 hospitalizations and 10,000 deaths associated with RSV occur annually in people over the age of 65 years in the United States. Although rhinorrhoea and wheezing are common symptoms among adults, the clinical syndrome associated with RSV is not distinctive and thus laboratory methods are required for specific diagnosis. Presently, the combination of reverse transcription PCR and enzyme immunoassay serology offers the best sensitivity and specificity for diagnosis of RSV. Treatment options are limited at present, with inhaled ribavirin being the only licensed drug for use in hospitalized children. Vaccines against RSV remain an unachieved goal. Promising new agents that inhibit the virus-cell fusion, cell-cell fusion, or viral gene expression are currently in development. </jats:p>",
  "DOI": "10.1177/135965350701200s03.1",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2022,
        4,
        14
      ]
    ],
    "date-time": "2022-04-14T16:00:45Z",
    "timestamp": 1649952045000
  },
  "page": "659-670",
  "source": "Crossref",
  "is-referenced-by-count": 40,
  "title": "Respiratory Syncytial Virus Infection in Adults",
  "prefix": "10.1177",
  "volume": "12",
  "author": [
    {
      "given": "Yoshihiko",
      "family": "Murata",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Infectious Diseases Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester Genera Hospital, New York, USA"
        }
      ]
    },
    {
      "given": "Ann R",
      "family": "Falsey",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Infectious Diseases Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester Genera Hospital, New York, USA"
        }
      ]
    }
  ],
  "member": "179",
  "published-online": {
    "date-parts": [
      [
        2007,
        1,
        1
      ]
    ]
  },
  "reference": [
    {
      "key": "bibr1-135965350701200S03.1",
      "first-page": "281",
      "volume": "66",
      "author": "Chanock R.",
      "year": "1957",
      "journal-title": "Am J Hyg"
    },
    {
      "key": "bibr2-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.7326/0003-4819-109-3-203"
    },
    {
      "key": "bibr3-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJMoa043951"
    },
    {
      "key": "bibr4-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/jama.289.2.179"
    },
    {
      "key": "bibr5-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/978-1-4615-3790-8_4"
    },
    {
      "key": "bibr6-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.84.16.5625"
    },
    {
      "key": "bibr7-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/infdis/155.6.1198"
    },
    {
      "key": "bibr8-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/CMR.13.3.371"
    },
    {
      "key": "bibr9-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.vaccine.2006.09.041"
    },
    {
      "key": "bibr10-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/archinte.162.11.1229"
    },
    {
      "key": "bibr11-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/bmj.281.6250.1253-a"
    },
    {
      "key": "bibr12-135965350701200S03.1",
      "first-page": "351",
      "volume": "26",
      "author": "Center for Disease Control.",
      "year": "1977",
      "journal-title": "MMWR"
    },
    {
      "key": "bibr13-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1532-5415.1995.tb06238.x"
    },
    {
      "key": "bibr14-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/bmj.315.7115.1060"
    },
    {
      "key": "bibr15-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0140-6736(01)06528-X"
    },
    {
      "key": "bibr16-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/infdis/174.3.456"
    },
    {
      "key": "bibr17-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1164/ajrccm.160.3.9901004"
    },
    {
      "key": "bibr18-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0140-6736(63)90894-8"
    },
    {
      "key": "bibr19-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJM196401162700303"
    },
    {
      "key": "bibr20-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/thorax.58.1.37"
    },
    {
      "key": "bibr21-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1164/ajrccm.164.9.2105011"
    },
    {
      "key": "bibr22-135965350701200S03.1",
      "unstructured": "Rohde G., Borg I., Arinir U. The role of RSV in respiratory infections in adults. 101st International Meeting of the American Thoracic Society. 23 May 2005, San Diego, USA. Poster J77."
    },
    {
      "key": "bibr23-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1183/09031936.03.00088102"
    },
    {
      "key": "bibr24-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1164/rccm.200509-1489OC"
    },
    {
      "key": "bibr25-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1164/rccm.200510-1681OC"
    },
    {
      "key": "bibr26-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1532-5415.1992.tb01929.x"
    },
    {
      "key": "bibr27-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/511986"
    },
    {
      "key": "bibr28-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1532-5415.1995.tb06384.x"
    },
    {
      "key": "bibr29-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.7326/0003-4819-93-1-49"
    },
    {
      "key": "bibr30-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0163-4453(84)90530-9"
    },
    {
      "key": "bibr31-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1386-6532(02)00084-7"
    },
    {
      "key": "bibr32-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jcm.34.7.1649-1653.1996"
    },
    {
      "key": "bibr33-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.7326/0003-4819-88-2-203"
    },
    {
      "key": "bibr34-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1532-5415.1996.tb05641.x"
    },
    {
      "key": "bibr35-135965350701200S03.1",
      "first-page": "451",
      "volume": "115",
      "author": "Kellogg J.A.",
      "year": "1991",
      "journal-title": "Arch Pathol Lab Med"
    },
    {
      "key": "bibr36-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JCM.42.7.2996-2999.2004"
    },
    {
      "key": "bibr37-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1386-6532(03)00002-7"
    },
    {
      "key": "bibr38-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JCM.44.3.1105-1107.2006"
    },
    {
      "key": "bibr39-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JCM.40.3.817-820.2002"
    },
    {
      "key": "bibr40-135965350701200S03.1",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1086/516284",
      "volume": "26",
      "author": "Fan J.",
      "year": "1998",
      "journal-title": "Clin Infect Dis"
    },
    {
      "key": "bibr41-135965350701200S03.1",
      "first-page": "13",
      "volume": "21",
      "author": "Freymuth",
      "year": "2000",
      "journal-title": "Rev Mal Respir"
    },
    {
      "key": "bibr42-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JCM.41.9.4160-4165.2003"
    },
    {
      "key": "bibr43-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/S10096-006-0112-4"
    },
    {
      "key": "bibr44-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jcm.28.12.2744-2749.1990"
    },
    {
      "key": "bibr45-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jcm.26.5.808-811.1988"
    },
    {
      "key": "bibr46-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1586/14787210.3.6.945"
    },
    {
      "key": "bibr47-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/01.inf.0000053892.99856.ef"
    },
    {
      "key": "bibr48-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJM198306163082403"
    },
    {
      "key": "bibr49-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/archpedi.153.5.469"
    },
    {
      "key": "bibr50-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1378/chest.93.6.1239"
    },
    {
      "key": "bibr51-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0022-5223(94)70168-7"
    },
    {
      "key": "bibr52-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0022-3476(05)80554-2"
    },
    {
      "key": "bibr53-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.antiviral.2005.06.009"
    },
    {
      "key": "bibr54-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.antiviral.2003.07.002"
    },
    {
      "key": "bibr55-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0166-3542(98)00002-3"
    },
    {
      "key": "bibr56-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/AAC.48.7.2448-2454.2004"
    },
    {
      "key": "bibr57-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/AAC.48.2.413-422.2004"
    },
    {
      "key": "bibr58-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/AAC.46.3.841-847.2002"
    },
    {
      "key": "bibr59-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.antiviral.2003.07.004"
    },
    {
      "key": "bibr60-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1099/0022-1317-65-4-761"
    },
    {
      "key": "bibr61-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/viro.1994.1245"
    },
    {
      "key": "bibr62-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.25.13961"
    },
    {
      "key": "bibr63-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JVI.73.8.6610-6617.1999"
    },
    {
      "key": "bibr64-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/AAC.35.12.2515"
    },
    {
      "key": "bibr65-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/jac/dkh355"
    },
    {
      "key": "bibr66-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0166-3542(96)01019-4"
    },
    {
      "key": "bibr67-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0166-3542(03)00009-3"
    },
    {
      "key": "bibr68-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JVI.79.20.13105-13115.2005"
    },
    {
      "key": "bibr69-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.antiviral.2004.12.002"
    },
    {
      "key": "bibr70-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.coph.2005.05.003"
    },
    {
      "key": "bibr71-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/rmv.423"
    },
    {
      "key": "bibr72-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.antiviral.2003.10.005"
    },
    {
      "key": "bibr73-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1069132"
    },
    {
      "key": "bibr74-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nm1164"
    },
    {
      "key": "bibr75-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nm1174"
    },
    {
      "key": "bibr76-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0166-3542(93)90065-Q"
    },
    {
      "key": "bibr77-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.antiviral.2005.09.003"
    },
    {
      "key": "bibr78-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJM199311183292102"
    },
    {
      "key": "bibr79-135965350701200S03.1",
      "first-page": "463",
      "volume": "95",
      "author": "Groothuis J.R.",
      "year": "1995",
      "journal-title": "Pediatrics"
    },
    {
      "key": "bibr80-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1542/peds.102.3.531"
    },
    {
      "key": "bibr81-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/322043"
    },
    {
      "key": "bibr82-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.bmt.1702228"
    },
    {
      "key": "bibr83-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/380907"
    },
    {
      "key": "bibr84-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jmv.20090"
    },
    {
      "key": "bibr85-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/421524"
    },
    {
      "key": "bibr86-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/oxfordjournals.aje.a120956"
    },
    {
      "key": "bibr87-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/oxfordjournals.aje.a120955"
    },
    {
      "key": "bibr88-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/oxfordjournals.aje.a120957"
    },
    {
      "key": "bibr89-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0264-410X(96)00030-8"
    },
    {
      "key": "bibr90-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0264-410X(97)00002-9"
    },
    {
      "key": "bibr91-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0264-410X(03)00352-9"
    },
    {
      "key": "bibr92-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/324426"
    },
    {
      "key": "bibr93-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/514138"
    },
    {
      "key": "bibr94-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0264-410X(98)00381-8"
    },
    {
      "key": "bibr95-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JVI.73.2.871-877.1999"
    },
    {
      "key": "bibr96-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/315859"
    },
    {
      "key": "bibr97-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0264-410X(99)00527-7"
    },
    {
      "key": "bibr98-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/viro.2002.1431"
    },
    {
      "key": "bibr99-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JVI.76.11.5654-5666.2002"
    },
    {
      "key": "bibr100-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0264-410X(93)90284-5"
    },
    {
      "key": "bibr101-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/CMR.18.3.541-555.2005"
    },
    {
      "key": "bibr102-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0264-410X(91)90151-U"
    },
    {
      "key": "bibr103-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1203/00006450-199308000-00013"
    },
    {
      "key": "bibr104-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1513/pats.200503-022AW"
    },
    {
      "key": "bibr105-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI115362"
    },
    {
      "key": "bibr106-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1513/pats.200501-002AW"
    },
    {
      "key": "bibr107-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2249.1992.tb06482.x"
    },
    {
      "key": "bibr108-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI119391"
    },
    {
      "key": "bibr109-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1099/0022-1317-77-10-2447"
    },
    {
      "key": "bibr110-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/eji.1830271233"
    },
    {
      "key": "bibr111-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.3181/00379727-157-40112"
    },
    {
      "key": "bibr112-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.3181/00379727-160-40433"
    },
    {
      "key": "bibr113-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JVI.73.12.10086-10094.1999"
    },
    {
      "key": "bibr114-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/JVI.72.5.4080-4087.1998"
    },
    {
      "key": "bibr115-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0264-410X(90)90253-I"
    },
    {
      "key": "bibr116-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/intimm/4.4.493"
    },
    {
      "key": "bibr117-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/01.inf.0000078165.62923.15"
    },
    {
      "key": "bibr118-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1211/jpp.57.11.0001"
    },
    {
      "key": "bibr119-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/AAC.49.11.4700-4707.2005"
    },
    {
      "key": "bibr120-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/infdis/141.1.98"
    },
    {
      "key": "bibr121-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0022-3476(81)80969-9"
    },
    {
      "key": "bibr122-135965350701200S03.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0140-6736(92)93088-5"
    }
  ],
  "container-title": "Antiviral Therapy",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.sagepub.com/doi/pdf/10.1177/135965350701200S03.1",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://journals.sagepub.com/doi/pdf/10.1177/135965350701200S03.1",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2025,
        3,
        1
      ]
    ],
    "date-time": "2025-03-01T22:09:10Z",
    "timestamp": 1740866950000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.sagepub.com/doi/10.1177/135965350701200S03.1"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        1
      ]
    ]
  },
  "references-count": 122,
  "journal-issue": {
    "issue": "4_part_2",
    "published-print": {
      "date-parts": [
        [
          2007,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1177/135965350701200S03.1"
  ],
  "URL": "http://dx.doi.org/10.1177/135965350701200S03.1",
  "relation": {},
  "ISSN": [
    "1359-6535",
    "2040-2058"
  ],
  "subject": [],
  "container-title-short": "Antiviral Therapy",
  "published": {
    "date-parts": [
      [
        2007,
        1
      ]
    ]
  }
}