DOI: 10.1177/1087057113516861. Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens

Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens

10.1177/1087057113516861

Crossref journal-article

Elsevier BV

SLAS Discovery (78)

Bibliography

Schorpp, K., Rothenaigner, I., Salmina, E., Reinshagen, J., Low, T., Brenke, J. K., Gopalakrishnan, J., Tetko, I. V., Gul, S., & Hadian, K. (2014). Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens. SLAS Discovery, 19(5), 715â726.

Authors 10

Kenji Schorpp (first)
Ina Rothenaigner (additional)
Elena Salmina (additional)
Jeanette Reinshagen (additional)
Terence Low (additional)
Jara K. Brenke (additional)
Jay Gopalakrishnan (additional)
Igor V. Tetko (additional)
Sheraz Gul (additional)
Kamyar Hadian (additional)

References 35 Referenced 78

10.1038/nrd2199 / Nat. Rev. Drug Discov. / How Many Drug Targets Are There? by Overington (2006)
10.1016/j.sbi.2005.06.001 / Curr. Opin. Struct. Biol. / Protein-Protein Interactions in Human Disease by Ryan (2005)
10.1016/j.drudis.2009.11.007 / Drug Discov. Today / Rationalizing the Chemical Space of Protein-Protein Interaction Inhibitors by Sperandio (2010)
10.1038/nchembio0306-112 / Nat. Chem. Biol. / Between a Rock and a Hard Place? by Whitty (2006)
10.1016/S1074-5521(00)00106-X / Chem. Biol. / Antagonists of Protein-Protein Interactions by Cochran (2000)
10.4155/fmc.09.12 / Fut. Med. Chem. / Targeting Protein-Protein Interactions for therapeutic Intervention: A Challenge for the Future by Zinzalla (2009)
10.1038/nature06526 / Nature / Reaching for High-Hanging Fruit in Drug Discovery at Protein-Protein Interfaces by Wells (2007)
10.1089/adt.2011.0380 / Assay Drug Dev. Technol. / Molecular interaction Studies Using Microscale Thermophoresis by Jerabek-Willemsen (2011)
10.1007/978-1-59745-483-4_14 / Methods Mol. Biol. / Analysis of Biomolecules Using Surface Plasmons by Willander (2009)
10.1002/jmr.1167 / J. Mol. Recogn. / Applications of Isothermal Titration Calorimetry in Pure and Applied Research—Survey of the Literature from 2010 by Ghai (2012)
10.1038/nrd3368 / Nat. Rev. Drug Discov. / Impact of High-Throughput Screening in Biomedical Research by Macarron (2011)
10.1021/ja802977h / J. Am. Chem. Soc. / Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors by Coan (2008)
10.1021/jm901137j / J. Med. Chem. / New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays by Baell (2010)
10.1016/S0169-409X(00)00129-0 / Adv. Drug Deliv. Rev. / Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings by Lipinski (2001)
10.1021/ci400213d / J. Chem. Inf. Model. / Development of Dimethyl Sulfoxide Solubility Models Using 163 000 Molecules: Using a Domain Applicability Metric to Select More Reliable Predictions by Tetko (2013)
10.1021/ci000392t / J. Chem. Inf. Comput. Sci. / Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices by Tetko (2001)
10.1002/cem.1296 / J. Chemometrics / Applicability Domain for In Silico Models to Achieve Accuracy of Experimental Measurements by Sushko (2010)
10.1021/ci300245q / J. Chem. Inf. Model. / ToxAlerts: A Web Server of Structural Alerts for Toxic Chemicals and Compounds with Potential Adverse Reactions by Sushko (2012)
SMARTS—A Language for Describing Molecular Patterns. http://www.daylight.com/dayhtml/doc/theory/theory.smarts.html
10.1021/ci050504m / J. Chem. Inf. Model. / An Empirical Process for the Design of High-Throughput Screening Deck Filters by Pearce (2006)
10.1007/s10822-011-9440-2 / J. Comput. Aided. Mol. Des. / Online Chemical Modeling Environment (OCHEM): Web Platform for Data Storage, Model Development and Publishing of Chemical Information by Sushko (2011)
10.1038/nchembio.187 / Nat. Chem. Biol. / Interactive Exploration of Chemical Space with Scaffold Hunter by Wetzel (2009)
10.2174/157340908785747465 / Cur. Comp. Aid. Drug Des. / ISIDA—Platform for Virtual Screening Based on Fragment and Pharmacophoric Descriptors by Varnek (2008)
Strip-it. http://silicos-it.com/software/strip-it/1.0.2/strip-it.html. Accessed July 8, 2013.
10.1093/nar/gkr1132 / Nucleic Acids Res. / PubChem’s BioAssay Database by Wang (2012)
10.1517/17460441.2010.495748 / Exp. Opin. Drug Discov. / Exemplification of the Challenges Associated with Utilising Fluorescence Intensity Based Assays in Discovery by Gul (2010)
10.1016/0076-6879(90)84259-J / Methods Enzymol. / Avidin and Streptavidin by Green (1990)
Slepukhin, P. A., Salmina, E. S., Potemkin, V. A., et al. Crystal and Electronic Structure of Heteromolecular Complexes of 3,6-bis-(3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazine with Azoles. J. Struct. Chem. 2013, in press. (10.1134/S0022476613060139)
10.1134/S0022476611060187 / J. Struct. Chem. / Intermolecular Interactions in Heteromolecular Crystals of Tetrazine Derivatives with Azoles by Salmina (2011)
10.1016/S0010-8545(02)00044-9 / Coord. Chem. Rev. / The Coordination Chemistry of 1,2,4,5-Tetrazines by Kaim (2002)
10.1016/j.ccr.2007.06.003 / Coord. Chem. Rev. / 8-Hydroxyquinolines in Metallosupramolecular Chemistry by Albrecht (2008)
10.1039/c0ob00983k / Org. Biomol. Chem. / An 2-(2′-Aminophenyl)Benzoxazole-Based OFF-ON Fluorescent Chemosensor for Zn2+ in Aqueous Solution by Chen (2011)
10.1039/c0dt01807d / Dalton Trans. / 1-(2-Picolyl)-Substituted 1,2,3-Triazole as Novel Chelating Ligand for the Preparation of Ruthenium Complexes with Potential Anticancer Activity by Bratsos (2011)
10.1039/a708334c / N J Chem. / Functionalised 3,3[Prime or Minute]-Bipyridines—A New Class of Dinucleating Ligands by Constable (1998)
10.1002/cmdc.200900516 / ChemMedChem / Chelator Fragment Libraries for Targeting Metalloproteinases by Agrawal (2010)

Dates

Type	When
Created	11 years, 8 months ago (Dec. 26, 2013, 9:41 p.m.)
Deposited	2 years, 9 months ago (Nov. 19, 2022, 12:16 p.m.)
Indexed	1 month, 2 weeks ago (July 19, 2025, 11:35 p.m.)
Issued	11 years, 3 months ago (June 1, 2014)
Published	11 years, 3 months ago (June 1, 2014)
Published Print	11 years, 3 months ago (June 1, 2014)

Funders 0

None

BibTeX

@article{Schorpp_2014, title={Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens}, volume={19}, ISSN={2472-5552}, url={http://dx.doi.org/10.1177/1087057113516861}, DOI={10.1177/1087057113516861}, number={5}, journal={SLAS Discovery}, publisher={Elsevier BV}, author={Schorpp, Kenji and Rothenaigner, Ina and Salmina, Elena and Reinshagen, Jeanette and Low, Terence and Brenke, Jara K. and Gopalakrishnan, Jay and Tetko, Igor V. and Gul, Sheraz and Hadian, Kamyar}, year={2014}, month=jun, pages={715–726} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        20
      ]
    ],
    "date-time": "2025-07-20T03:35:03Z",
    "timestamp": 1752982503867
  },
  "reference-count": 35,
  "publisher": "Elsevier BV",
  "issue": "5",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2014,
            6,
            1
          ]
        ],
        "date-time": "2014-06-01T00:00:00Z",
        "timestamp": 1401580800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2022,
            4,
            6
          ]
        ],
        "date-time": "2022-04-06T00:00:00Z",
        "timestamp": 1649203200000
      },
      "content-version": "vor",
      "delay-in-days": 2866,
      "URL": "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    }
  ],
  "content-domain": {
    "domain": [
      "slas-discovery.org",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2014,
        6
      ]
    ]
  },
  "DOI": "10.1177/1087057113516861",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2013,
        12,
        27
      ]
    ],
    "date-time": "2013-12-27T02:41:16Z",
    "timestamp": 1388112076000
  },
  "page": "715-726",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 78,
  "title": "Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens",
  "prefix": "10.1016",
  "volume": "19",
  "author": [
    {
      "given": "Kenji",
      "family": "Schorpp",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Ina",
      "family": "Rothenaigner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Elena",
      "family": "Salmina",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jeanette",
      "family": "Reinshagen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Terence",
      "family": "Low",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jara K.",
      "family": "Brenke",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jay",
      "family": "Gopalakrishnan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Igor V.",
      "family": "Tetko",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Sheraz",
      "family": "Gul",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Kamyar",
      "family": "Hadian",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1177/1087057113516861_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "993",
      "DOI": "10.1038/nrd2199",
      "article-title": "How Many Drug Targets Are There?",
      "volume": "5",
      "author": "Overington",
      "year": "2006",
      "journal-title": "Nat. Rev. Drug Discov."
    },
    {
      "key": "10.1177/1087057113516861_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "441",
      "DOI": "10.1016/j.sbi.2005.06.001",
      "article-title": "Protein-Protein Interactions in Human Disease",
      "volume": "15",
      "author": "Ryan",
      "year": "2005",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1177/1087057113516861_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "220",
      "DOI": "10.1016/j.drudis.2009.11.007",
      "article-title": "Rationalizing the Chemical Space of Protein-Protein Interaction Inhibitors",
      "volume": "15",
      "author": "Sperandio",
      "year": "2010",
      "journal-title": "Drug Discov. Today"
    },
    {
      "key": "10.1177/1087057113516861_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "112",
      "DOI": "10.1038/nchembio0306-112",
      "article-title": "Between a Rock and a Hard Place?",
      "volume": "2",
      "author": "Whitty",
      "year": "2006",
      "journal-title": "Nat. Chem. Biol."
    },
    {
      "key": "10.1177/1087057113516861_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "R85",
      "DOI": "10.1016/S1074-5521(00)00106-X",
      "article-title": "Antagonists of Protein-Protein Interactions",
      "volume": "7",
      "author": "Cochran",
      "year": "2000",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "10.1177/1087057113516861_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.4155/fmc.09.12",
      "article-title": "Targeting Protein-Protein Interactions for therapeutic Intervention: A Challenge for the Future",
      "volume": "1",
      "author": "Zinzalla",
      "year": "2009",
      "journal-title": "Fut. Med. Chem."
    },
    {
      "key": "10.1177/1087057113516861_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "1001",
      "DOI": "10.1038/nature06526",
      "article-title": "Reaching for High-Hanging Fruit in Drug Discovery at Protein-Protein Interfaces",
      "volume": "450",
      "author": "Wells",
      "year": "2007",
      "journal-title": "Nature"
    },
    {
      "key": "10.1177/1087057113516861_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "342",
      "DOI": "10.1089/adt.2011.0380",
      "article-title": "Molecular interaction Studies Using Microscale Thermophoresis",
      "volume": "9",
      "author": "Jerabek-Willemsen",
      "year": "2011",
      "journal-title": "Assay Drug Dev. Technol."
    },
    {
      "key": "10.1177/1087057113516861_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.1007/978-1-59745-483-4_14",
      "article-title": "Analysis of Biomolecules Using Surface Plasmons",
      "volume": "544",
      "author": "Willander",
      "year": "2009",
      "journal-title": "Methods Mol. Biol."
    },
    {
      "key": "10.1177/1087057113516861_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "32",
      "DOI": "10.1002/jmr.1167",
      "article-title": "Applications of Isothermal Titration Calorimetry in Pure and Applied Research\u2014Survey of the Literature from 2010",
      "volume": "25",
      "author": "Ghai",
      "year": "2012",
      "journal-title": "J. Mol. Recogn."
    },
    {
      "key": "10.1177/1087057113516861_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1038/nrd3368",
      "article-title": "Impact of High-Throughput Screening in Biomedical Research",
      "volume": "10",
      "author": "Macarron",
      "year": "2011",
      "journal-title": "Nat. Rev. Drug Discov."
    },
    {
      "key": "10.1177/1087057113516861_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "9606",
      "DOI": "10.1021/ja802977h",
      "article-title": "Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors",
      "volume": "130",
      "author": "Coan",
      "year": "2008",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1177/1087057113516861_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "2719",
      "DOI": "10.1021/jm901137j",
      "article-title": "New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays",
      "volume": "53",
      "author": "Baell",
      "year": "2010",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "10.1177/1087057113516861_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "3",
      "DOI": "10.1016/S0169-409X(00)00129-0",
      "article-title": "Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings",
      "volume": "46",
      "author": "Lipinski",
      "year": "2001",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1177/1087057113516861_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "1990",
      "DOI": "10.1021/ci400213d",
      "article-title": "Development of Dimethyl Sulfoxide Solubility Models Using 163 000 Molecules: Using a Domain Applicability Metric to Select More Reliable Predictions",
      "volume": "53",
      "author": "Tetko",
      "year": "2013",
      "journal-title": "J. Chem. Inf. Model."
    },
    {
      "key": "10.1177/1087057113516861_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "1488",
      "DOI": "10.1021/ci000392t",
      "article-title": "Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices",
      "volume": "41",
      "author": "Tetko",
      "year": "2001",
      "journal-title": "J. Chem. Inf. Comput. Sci."
    },
    {
      "key": "10.1177/1087057113516861_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "202",
      "DOI": "10.1002/cem.1296",
      "article-title": "Applicability Domain for In Silico Models to Achieve Accuracy of Experimental Measurements",
      "volume": "24",
      "author": "Sushko",
      "year": "2010",
      "journal-title": "J. Chemometrics"
    },
    {
      "key": "10.1177/1087057113516861_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "2310",
      "DOI": "10.1021/ci300245q",
      "article-title": "ToxAlerts: A Web Server of Structural Alerts for Toxic Chemicals and Compounds with Potential Adverse Reactions",
      "volume": "52",
      "author": "Sushko",
      "year": "2012",
      "journal-title": "J. Chem. Inf. Model."
    },
    {
      "key": "10.1177/1087057113516861_bib19",
      "unstructured": "SMARTS\u2014A Language for Describing Molecular Patterns. http://www.daylight.com/dayhtml/doc/theory/theory.smarts.html"
    },
    {
      "key": "10.1177/1087057113516861_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "1060",
      "DOI": "10.1021/ci050504m",
      "article-title": "An Empirical Process for the Design of High-Throughput Screening Deck Filters",
      "volume": "46",
      "author": "Pearce",
      "year": "2006",
      "journal-title": "J. Chem. Inf. Model."
    },
    {
      "key": "10.1177/1087057113516861_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "533",
      "DOI": "10.1007/s10822-011-9440-2",
      "article-title": "Online Chemical Modeling Environment (OCHEM): Web Platform for Data Storage, Model Development and Publishing of Chemical Information",
      "volume": "25",
      "author": "Sushko",
      "year": "2011",
      "journal-title": "J. Comput. Aided. Mol. Des."
    },
    {
      "key": "10.1177/1087057113516861_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "581",
      "DOI": "10.1038/nchembio.187",
      "article-title": "Interactive Exploration of Chemical Space with Scaffold Hunter",
      "volume": "5",
      "author": "Wetzel",
      "year": "2009",
      "journal-title": "Nat. Chem. Biol."
    },
    {
      "key": "10.1177/1087057113516861_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "191",
      "DOI": "10.2174/157340908785747465",
      "article-title": "ISIDA\u2014Platform for Virtual Screening Based on Fragment and Pharmacophoric Descriptors",
      "volume": "4",
      "author": "Varnek",
      "year": "2008",
      "journal-title": "Cur. Comp. Aid. Drug Des."
    },
    {
      "key": "10.1177/1087057113516861_bib24",
      "unstructured": "Strip-it. http://silicos-it.com/software/strip-it/1.0.2/strip-it.html. Accessed July 8, 2013."
    },
    {
      "key": "10.1177/1087057113516861_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "D400",
      "DOI": "10.1093/nar/gkr1132",
      "article-title": "PubChem\u2019s BioAssay Database",
      "volume": "40",
      "author": "Wang",
      "year": "2012",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1177/1087057113516861_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "681",
      "DOI": "10.1517/17460441.2010.495748",
      "article-title": "Exemplification of the Challenges Associated with Utilising Fluorescence Intensity Based Assays in Discovery",
      "volume": "5",
      "author": "Gul",
      "year": "2010",
      "journal-title": "Exp. Opin. Drug Discov."
    },
    {
      "key": "10.1177/1087057113516861_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "51",
      "DOI": "10.1016/0076-6879(90)84259-J",
      "article-title": "Avidin and Streptavidin",
      "volume": "184",
      "author": "Green",
      "year": "1990",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1177/1087057113516861_bib28",
      "doi-asserted-by": "crossref",
      "unstructured": "Slepukhin, P. A., Salmina, E. S., Potemkin, V. A., et al. Crystal and Electronic Structure of Heteromolecular Complexes of 3,6-bis-(3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazine with Azoles. J. Struct. Chem. 2013, in press.",
      "DOI": "10.1134/S0022476613060139"
    },
    {
      "key": "10.1177/1087057113516861_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "1134",
      "DOI": "10.1134/S0022476611060187",
      "article-title": "Intermolecular Interactions in Heteromolecular Crystals of Tetrazine Derivatives with Azoles",
      "volume": "52",
      "author": "Salmina",
      "year": "2011",
      "journal-title": "J. Struct. Chem."
    },
    {
      "key": "10.1177/1087057113516861_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/S0010-8545(02)00044-9",
      "article-title": "The Coordination Chemistry of 1,2,4,5-Tetrazines",
      "volume": "230",
      "author": "Kaim",
      "year": "2002",
      "journal-title": "Coord. Chem. Rev."
    },
    {
      "key": "10.1177/1087057113516861_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "812",
      "DOI": "10.1016/j.ccr.2007.06.003",
      "article-title": "8-Hydroxyquinolines in Metallosupramolecular Chemistry",
      "volume": "252",
      "author": "Albrecht",
      "year": "2008",
      "journal-title": "Coord. Chem. Rev."
    },
    {
      "key": "10.1177/1087057113516861_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "2345",
      "DOI": "10.1039/c0ob00983k",
      "article-title": "An 2-(2\u2032-Aminophenyl)Benzoxazole-Based OFF-ON Fluorescent Chemosensor for Zn2+ in Aqueous Solution",
      "volume": "9",
      "author": "Chen",
      "year": "2011",
      "journal-title": "Org. Biomol. Chem."
    },
    {
      "key": "10.1177/1087057113516861_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "5188",
      "DOI": "10.1039/c0dt01807d",
      "article-title": "1-(2-Picolyl)-Substituted 1,2,3-Triazole as Novel Chelating Ligand for the Preparation of Ruthenium Complexes with Potential Anticancer Activity",
      "volume": "40",
      "author": "Bratsos",
      "year": "2011",
      "journal-title": "Dalton Trans."
    },
    {
      "key": "10.1177/1087057113516861_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1039/a708334c",
      "article-title": "Functionalised 3,3[Prime or Minute]-Bipyridines\u2014A New Class of Dinucleating Ligands",
      "volume": "22",
      "author": "Constable",
      "year": "1998",
      "journal-title": "N J Chem."
    },
    {
      "key": "10.1177/1087057113516861_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1002/cmdc.200900516",
      "article-title": "Chelator Fragment Libraries for Targeting Metalloproteinases",
      "volume": "5",
      "author": "Agrawal",
      "year": "2010",
      "journal-title": "ChemMedChem"
    }
  ],
  "container-title": "SLAS Discovery",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://journals.sagepub.com/doi/pdf/10.1177/1087057113516861",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://journals.sagepub.com/doi/full-xml/10.1177/1087057113516861",
      "content-type": "application/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S2472555222073646?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S2472555222073646?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://journals.sagepub.com/doi/pdf/10.1177/1087057113516861",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        11,
        19
      ]
    ],
    "date-time": "2022-11-19T17:16:02Z",
    "timestamp": 1668878162000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S2472555222073646"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2014,
        6
      ]
    ]
  },
  "references-count": 35,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          2014,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S2472555222073646"
  ],
  "URL": "http://dx.doi.org/10.1177/1087057113516861",
  "relation": {},
  "ISSN": [
    "2472-5552"
  ],
  "subject": [],
  "container-title-short": "SLAS Discovery",
  "published": {
    "date-parts": [
      [
        2014,
        6
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "SLAS Discovery",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1177/1087057113516861",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2014 Society for Laboratory Automation and Screening. Published by Elsevier Inc.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}