DOI: 10.1177/014107689108401207. Breast Liver Metastases

Breast Liver Metastases – Incidence, Diagnosis and Outcome

10.1177/014107689108401207

Crossref journal-article

SAGE Publications

Journal of the Royal Society of Medicine (179)

Abstract

Breast liver metastases are uncommon and have not been well reported. We studied the clinical outcome of 47 patients who developed liver metastases out of 912 breast cancer patients treated between 1982 and 1987, an incidence of 5.2%. The median disease free interval prior to clinical liver metastases was 20.2 months (range 4–192 months). The most frequent clinical presentations were hepatomegaly (70%) and abdominal pain (34%). The diagnosis was confirmed on ultrasound scan in 72.7% patients. Thirty-one patients (70.5%) received specific treatment with both hormone and chemotherapy but only six showed any evidence of objective response, the majority of whom had metastases only in the liver. The median survival of treated patients was 4 months and absence of jaundice, response to treatment and liver metastases only were associated with significantly better survival. In conclusion breast liver metastases usually present as a manifestation of disseminated disease and have an appalling prognosis. When they occur as an initial site the prognosis is better but very few patients overall respond to conventional treatment.

Bibliography

Hoe, A. L., Royle, G. T., & Taylor, I. (1991). Breast Liver Metastases â Incidence, Diagnosis and Outcome. Journal of the Royal Society of Medicine, 84(12), 714â716.

Authors 3

A L Hoe (first)
G T Royle (additional)
I Taylor (additional)

References 23 Referenced 114

{'key': 'bibr1-014107689108401207', 'first-page': '460', 'volume-title': 'Diseases of the liver and biliary system', 'author': 'Sherlock S.', 'year': '1981', 'edition': '6'} / Diseases of the liver and biliary system by Sherlock S. (1981)
{'key': 'bibr2-014107689108401207', 'first-page': '175', 'volume-title': 'The spread of tumours in the human body.', 'author': 'Willis R.A.', 'year': '1973'} / The spread of tumours in the human body. by Willis R.A. (1973)
10.1080/01621459.1958.10501452
10.1038/bjc.1977.1
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10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6
{'key': 'bibr7-014107689108401207', 'first-page': '510', 'volume': '167', 'author': 'Clark C.P.', 'year': '1988', 'journal-title': 'Surg Gynecol Obstet'} / Surg Gynecol Obstet by Clark C.P. (1988)
{'key': 'bibr8-014107689108401207', 'first-page': '225', 'volume': '6', 'author': 'De Rivas L.', 'year': '1980', 'journal-title': 'Clin Oncol'} / Clin Oncol by De Rivas L. (1980)
10.1016/0305-7372(90)90075-Q
10.1097/00007611-198809000-00011
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10.1002/1097-0142(19870415)59:8<1524::AID-CNCR2820590823>3.0.CO;2-9
10.1002/1097-0142(196603)19:3<421::AID-CNCR2820190316>3.0.CO;2-V
10.1038/bjc.1973.40
{'key': 'bibr15-014107689108401207', 'first-page': '149', 'volume': '3', 'author': 'Ozarda A.', 'year': '1962', 'journal-title': 'J Nucl Med'} / J Nucl Med by Ozarda A. (1962)
10.1097/00000658-198204000-00017
10.1016/0002-9343(61)90112-7
10.1136/gut.13.11.926
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{'key': 'bibr20-014107689108401207', 'first-page': '677', 'volume': '17', 'author': 'Drum D.E.', 'year': '1987', 'journal-title': 'J Nucl Med'} / J Nucl Med by Drum D.E. (1987)
10.1148/radiology.149.1.6611929
{'key': 'bibr22-014107689108401207', 'first-page': '1', 'volume': '127', 'author': 'Jaffe B.M.', 'year': '1968', 'journal-title': 'Surg Gynecol Obstet'} / Surg Gynecol Obstet by Jaffe B.M. (1968)
10.1002/1097-0142(196911)24:5<861::AID-CNCR2820240502>3.0.CO;2-3

Dates

Type	When
Created	7 years, 6 months ago (Feb. 28, 2018, 2:27 a.m.)
Deposited	5 months, 3 weeks ago (March 4, 2025, 7:23 a.m.)
Indexed	1 week, 4 days ago (Aug. 20, 2025, 9:21 a.m.)
Issued	33 years, 8 months ago (Dec. 1, 1991)
Published	33 years, 8 months ago (Dec. 1, 1991)
Published Online	33 years, 8 months ago (Dec. 1, 1991)
Published Print	33 years, 8 months ago (Dec. 1, 1991)

Funders 0

None

BibTeX

@article{Hoe_1991, title={Breast Liver Metastases – Incidence, Diagnosis and Outcome}, volume={84}, ISSN={1758-1095}, url={http://dx.doi.org/10.1177/014107689108401207}, DOI={10.1177/014107689108401207}, number={12}, journal={Journal of the Royal Society of Medicine}, publisher={SAGE Publications}, author={Hoe, A L and Royle, G T and Taylor, I}, year={1991}, month=dec, pages={714–716} }

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  "abstract": "<jats:p> Breast liver metastases are uncommon and have not been well reported. We studied the clinical outcome of 47 patients who developed liver metastases out of 912 breast cancer patients treated between 1982 and 1987, an incidence of 5.2%. </jats:p><jats:p> The median disease free interval prior to clinical liver metastases was 20.2 months (range 4\u2013192 months). The most frequent clinical presentations were hepatomegaly (70%) and abdominal pain (34%). The diagnosis was confirmed on ultrasound scan in 72.7% patients. </jats:p><jats:p> Thirty-one patients (70.5%) received specific treatment with both hormone and chemotherapy but only six showed any evidence of objective response, the majority of whom had metastases only in the liver. </jats:p><jats:p> The median survival of treated patients was 4 months and absence of jaundice, response to treatment and liver metastases only were associated with significantly better survival. </jats:p><jats:p> In conclusion breast liver metastases usually present as a manifestation of disseminated disease and have an appalling prognosis. When they occur as an initial site the prognosis is better but very few patients overall respond to conventional treatment. </jats:p>",
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