DOI: 10.1177/002215549904700503. Distribution of Signaling Molecules Involved in Vasopressin-induced Ca<sup>2+</sup>Mobilization in Rat Hepatocyte Multiplets

Distribution of Signaling Molecules Involved in Vasopressin-induced Ca2+Mobilization in Rat Hepatocyte Multiplets

10.1177/002215549904700503

Crossref journal-article

SAGE Publications

Journal of Histochemistry & Cytochemistry (179)

Abstract

In freshly isolated rat hepatocyte multiplets, Ca2+signals in response to vasopressin are highly organized. In this study we used specific probes to visualize, by fluorescence and confocal microscopy, the main signaling molecules involved in vasopressin-mediated Ca2+responses. V1a receptors were detected with a novel fluorescent antagonist, Rhm8-PVA. The Gαq/Gα11, PLCβ3, PIP2, and InsP3receptors were detected with specific antibodies. V1a vasopressin receptors and PIP2were associated with the basolateral membrane and were not detected in the bile canalicular domain. Gαq/Gα11, PLCβ3, and InsP3receptors were associated with the basolateral membrane and also with other intracellular structures. We used double labeling, Western blotting, and drugs (cytochalasin D, colchicine) known to disorganize the cytoskeleton to demonstrate the partial co-localization of Gαq/Gα11 with F-actin.

Bibliography

Tran, D., Stelly, N., Tordjmann, T., Durroux, T., Dufour, M. N., Forchioni, A., Seyer, R., Claret, M., & Guillon, G. (1999). Distribution of Signaling Molecules Involved in Vasopressin-induced Ca2+Mobilization in Rat Hepatocyte Multiplets. Journal of Histochemistry & Cytochemistry, 47(5), 601â616.

Authors 9

Dien Tran (first)
Nicole Stelly (additional)
Thierry Tordjmann (additional)
Thierry Durroux (additional)
Marie Noelle Dufour (additional)
Arlette Forchioni (additional)
René Seyer (additional)
Michel Claret (additional)
Gilles Guillon (additional)

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Dates

Type	When
Created	14 years, 5 months ago (April 1, 2011, 3:11 a.m.)
Deposited	6 months ago (March 4, 2025, 2:40 p.m.)
Indexed	6 months ago (March 5, 2025, 12:45 a.m.)
Issued	26 years, 4 months ago (May 1, 1999)
Published	26 years, 4 months ago (May 1, 1999)
Published Online	26 years, 4 months ago (May 1, 1999)
Published Print	26 years, 4 months ago (May 1, 1999)

Funders 0

None

BibTeX

@article{Tran_1999, title={Distribution of Signaling Molecules Involved in Vasopressin-induced Ca2+Mobilization in Rat Hepatocyte Multiplets}, volume={47}, ISSN={1551-5044}, url={http://dx.doi.org/10.1177/002215549904700503}, DOI={10.1177/002215549904700503}, number={5}, journal={Journal of Histochemistry & Cytochemistry}, publisher={SAGE Publications}, author={Tran, Dien and Stelly, Nicole and Tordjmann, Thierry and Durroux, Thierry and Dufour, Marie Noelle and Forchioni, Arlette and Seyer, René and Claret, Michel and Guillon, Gilles}, year={1999}, month=may, pages={601–616} }

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  "abstract": "<jats:p>In freshly isolated rat hepatocyte multiplets, Ca<jats:sup>2+</jats:sup>signals in response to vasopressin are highly organized. In this study we used specific probes to visualize, by fluorescence and confocal microscopy, the main signaling molecules involved in vasopressin-mediated Ca<jats:sup>2+</jats:sup>responses. V1a receptors were detected with a novel fluorescent antagonist, Rhm<jats:sup>8</jats:sup>-PVA. The G\u03b1q/G\u03b111, PLC\u03b2<jats:sub>3</jats:sub>, PIP<jats:sub>2</jats:sub>, and InsP<jats:sub>3</jats:sub>receptors were detected with specific antibodies. V1a vasopressin receptors and PIP<jats:sub>2</jats:sub>were associated with the basolateral membrane and were not detected in the bile canalicular domain. G\u03b1q/G\u03b111, PLC\u03b2<jats:sub>3</jats:sub>, and InsP<jats:sub>3</jats:sub>receptors were associated with the basolateral membrane and also with other intracellular structures. We used double labeling, Western blotting, and drugs (cytochalasin D, colchicine) known to disorganize the cytoskeleton to demonstrate the partial co-localization of G\u03b1q/G\u03b111 with F-actin.</jats:p>",
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