DOI: 10.1172/jci44867. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

10.1172/jci44867

Crossref journal-article

American Society for Clinical Investigation

Journal of Clinical Investigation (232)

Bibliography

Igaz, L. M., Kwong, L. K., Lee, E. B., Chen-Plotkin, A., Swanson, E., Unger, T., Malunda, J., Xu, Y., Winton, M. J., Trojanowski, J. Q., & Lee, V. M.-Y. (2011). Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. Journal of Clinical Investigation, 121(2), 726â738.

Authors 11

Lionel M. Igaz (first)
Linda K. Kwong (additional)
Edward B. Lee (additional)
Alice Chen-Plotkin (additional)
Eric Swanson (additional)
Travis Unger (additional)
Joe Malunda (additional)
Yan Xu (additional)
Matthew J. Winton (additional)
John Q. Trojanowski (additional)
Virginia M.-Y. Lee (additional)

References 38 Referenced 368

10.1097/01.jnen.0000174335.27708.0a
10.1126/science.1134108
10.1093/hmg/ddl202
10.1038/nrneurol.2010.18
10.1111/j.1440-1789.2009.01091.x
10.1093/hmg/ddp303 / Hum Mol Genet. by Pesiridis (2009)
10.1074/jbc.M104236200
10.1128/JVI.69.6.3584-3596.1995 / J Virol. by Ou (1995)
10.1016/j.bbrc.2006.10.093
10.2353/ajpath.2007.070182
10.1074/jbc.M800342200 / J Biol Chem. by Winton (2008)
10.1007/s00401-010-0659-0
10.1074/jbc.M109.061846
10.1002/dvg.20584 / Genesis. by Wu (2010)
10.1073/pnas.1002176107 / Proc Natl Acad Sci U S A. by Chiang (2010)
10.1084/jem.20092164
10.1073/pnas.0908767106
10.1073/pnas.0912417107
10.1016/j.nbd.2010.06.017
10.1523/JNEUROSCI.1630-10.2010
10.1016/j.expneurol.2009.10.005
10.1126/science.274.5293.1678
10.1073/pnas.89.12.5547 / Proc Natl Acad Sci U S A. by Gossen (1992)
10.1002/ana.21425
10.1007/s00401-008-0477-9
10.1523/JNEUROSCI.19-08-03248.1999 / J Neurosci. by Carter (1999)
10.1038/nature04723
10.1016/j.brainres.2003.11.067
10.1073/pnas.0800546105
10.1038/emboj.2009.324
10.1016/j.mcn.2007.03.007
10.1074/jbc.M109.012195
10.1073/pnas.0913602107
10.1371/journal.pmed.0020355 / PLoS Med. by Jankowsky (2005)
10.1016/j.neuron.2007.01.010
10.1016/0006-8993(91)90306-G
10.2353/ajpath.2008.080003
10.1002/pmic.200400892

Dates

Type	When
Created	14 years, 7 months ago (Jan. 4, 2011, 10:46 a.m.)
Deposited	1 year, 4 months ago (April 2, 2024, 1:47 p.m.)
Indexed	1 week, 6 days ago (Aug. 19, 2025, 6:46 a.m.)
Issued	14 years, 7 months ago (Feb. 1, 2011)
Published	14 years, 7 months ago (Feb. 1, 2011)
Published Print	14 years, 7 months ago (Feb. 1, 2011)

Funders 0

None

BibTeX

@article{Igaz_2011, title={Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice}, volume={121}, ISSN={0021-9738}, url={http://dx.doi.org/10.1172/jci44867}, DOI={10.1172/jci44867}, number={2}, journal={Journal of Clinical Investigation}, publisher={American Society for Clinical Investigation}, author={Igaz, Lionel M. and Kwong, Linda K. and Lee, Edward B. and Chen-Plotkin, Alice and Swanson, Eric and Unger, Travis and Malunda, Joe and Xu, Yan and Winton, Matthew J. and Trojanowski, John Q. and Lee, Virginia M.-Y.}, year={2011}, month=feb, pages={726–738} }

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