DOI: 10.1162/089892999563652. “What”—Then—“Where” in Visual Working Memory: An Event-Related fMRI Study [Penn]

“What”—Then—“Where” in Visual Working Memory: An Event-Related fMRI Study

10.1162/089892999563652

Crossref journal-article

MIT Press - Journals

Journal of Cognitive Neuroscience (281)

Abstract

Abstract Behavioral studies indicate that spatial and object working memory are computed by dissociable subsystems. We investigated the neural bases of this dissociation with a whole-brain fMRI design and analysis technique that permitted direct assessment of delay-period activity, uncontaminated by other components of the trial. The task employed a “what”-then-“where” design, with an object and a spatial delay period incorporated in each trial; within-trial order of delay conditions was balanced across each scan. Our experiment failed to find evidence, at the single-subject level and at the group level, for anatomical segregation of spatial and object working memory function in the frontal cortex. Delay-period activity in the caudate nucleus revealed a sensitivity to position in the trial in the spatial, but not the object, condition. In posterior regions, spatial delay-period activity was associated with preferential recruitment of extrastriate areas falling within Brodmann's area 19 and, less reliably, the superior parietal lobule. Object-specific delay-period activity was found predominantly in ventral regions of the posterior cortex and demonstrated more topographic variability across subjects than did spatial working memory activity.

Bibliography

Postle, B. R., & DâEsposito, M. (1999). âWhatââThenââWhereâ in Visual Working Memory: An Event-Related fMRI Study. Journal of Cognitive Neuroscience, 11(6), 585â597.

Authors 2

Bradley R. Postle (first)
Mark D'Esposito (additional)

References 54 Referenced 178

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:55 a.m.)
Deposited	4 years, 1 month ago (July 27, 2021, 12:40 p.m.)
Indexed	2 months ago (July 1, 2025, 12:45 a.m.)
Issued	25 years, 10 months ago (Nov. 1, 1999)
Published	25 years, 10 months ago (Nov. 1, 1999)
Published Online	25 years, 10 months ago (Nov. 1, 1999)
Published Print	25 years, 10 months ago (Nov. 1, 1999)

Funders 0

None

BibTeX

@article{Postle_1999, title={“What”—Then—“Where” in Visual Working Memory: An Event-Related fMRI Study}, volume={11}, ISSN={1530-8898}, url={http://dx.doi.org/10.1162/089892999563652}, DOI={10.1162/089892999563652}, number={6}, journal={Journal of Cognitive Neuroscience}, publisher={MIT Press - Journals}, author={Postle, Bradley R. and D’Esposito, Mark}, year={1999}, month=nov, pages={585–597} }

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