DOI: 10.1161/circulationaha.104.522292. Intracoronary Injection of CD133-Positive Enriched Bone Marrow Progenitor Cells Promotes Cardiac Recovery After Recent Myocardial Infarction

Intracoronary Injection of CD133-Positive Enriched Bone Marrow Progenitor Cells Promotes Cardiac Recovery After Recent Myocardial Infarction

10.1161/circulationaha.104.522292

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Circulation (276)

Abstract

Background— Bone marrow CD133-postive (CD133 + ) cells possess high hematopoietic and angiogenic capacity. We tested the feasibility, safety, and functional effects of the use of enriched CD133 + progenitor cells after intracoronary administration in patients with recent myocardial infarction. Methods and Results— Among 35 patients with acute myocardial infarction treated with stenting, 19 underwent intracoronary administration of CD133 + progenitor cells (12.6±2.2×10 6 cells) 11.6±1.4 days later (group 1) and 16 did not (group 2). At 4 months, left ventricular ejection fraction increased significantly in group 1 (from 45.0±2.6% to 52.1±3.5%, P <0.05), but only tended to increase in case-matched group 2 patients (from 44.3±3.1% to 48.6±3.6%, P =NS). Likewise, left ventricular regional chordae shortening increased in group 1 (from 11.5±1.0% to 16.1±1.3%, P <0.05) but remained unchanged in group 2 patients (from 11.1±1.1% to 12.7±1.3%, P =NS). This was paralleled by reduction in the perfusion defect in group 1 (from 28.0±4.1% to 22.5±4.1%, P <0.05) and no change in group 2 (from 25.0±3.0% to 22.6±4.1%, P =NS). In group 1, two patients developed in-stent reocclusion, 7 developed in-stent restenosis, and 2 developed significant de novo lesion of the infarct-related artery. In group 2, four patients showed in-stent restenosis. In group 1 patients without reocclusion, glucose uptake shown by positron emission tomography with 18 fluorodeoxyglucose in the infarct-related territory increased from 51.2±2.6% to 57.5±3.5% ( P <0.05). No stem cell-related arrhythmias were noted, either clinically or during programmed stimulation studies at 4 months. Conclusion— In patients with recent myocardial infarction, intracoronary administration of enriched CD133 + cells is feasible but was associated with increased incidence of coronary events. Nevertheless, it seems to be associated with improved left ventricular performance paralleled with increased myocardial perfusion and viability.

Bibliography

Bartunek, J., Vanderheyden, M., Vandekerckhove, B., Mansour, S., De Bruyne, B., De Bondt, P., Van Haute, I., Lootens, N., Heyndrickx, G., & Wijns, W. (2005). Intracoronary Injection of CD133-Positive Enriched Bone Marrow Progenitor Cells Promotes Cardiac Recovery After Recent Myocardial Infarction. Circulation, 112(9_supplement).

Authors 10

Jozef Bartunek (first)
Marc Vanderheyden (additional)
Bart Vandekerckhove (additional)
Samer Mansour (additional)
Bernard De Bruyne (additional)
Pieter De Bondt (additional)
Inge Van Haute (additional)
Nele Lootens (additional)
Guy Heyndrickx (additional)
William Wijns (additional)

References 21 Referenced 236

10.1016/j.jacc.2004.06.001
10.1161/01.cir.0000034046.87607.1c
10.1161/01.cir.0000043246.74879.cd
10.1161/01.res.0000144798.54040.ed
10.1016/S0140-6736(04)16626-9
10.1038/86498
10.1038/35070587
10.1038/nature02446
10.1038/nature02460
10.1038/nm1040
10.1038/sj.leu.2402255
10.1182/blood-2002-03-0711
Quirici N, Soligo D, Caneva L, Servida F, Bossolasco P, Deliliers GL. Differentiation and expansion of endothelial cells from human bone marrow CD133+ cells. Br J Hematol. 2001; 115: 180–194. / Br J Hematol (2001)
10.1172/JCI0214327
10.1016/S0140-6736(03)12110-1
Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, Fichtner S, Korte T, Hornig B, Messinger D, Arseniev L, Hertenstein B, Ganser A, Drexler H. Monitoring of bone marrow cell homing to the infarcted human myocardium. Circulation. 2004; 110 (suppl III): III–436.Abstract. / Circulation (2004)
10.1016/j.jacc.2004.03.083
10.1038/sj.bmt.1702136
10.1016/j.jacc.2003.12.022
10.1161/01.cir.0000106161.43954.df
10.1161/01.CIR.0000132468.82942.F5

Dates

Type	When
Created	4 years, 2 months ago (July 2, 2021, 11:23 p.m.)
Deposited	1 year, 3 months ago (May 13, 2024, 1:08 a.m.)
Indexed	3 months, 2 weeks ago (May 16, 2025, 6:28 a.m.)
Issued	20 years ago (Aug. 30, 2005)
Published	20 years ago (Aug. 30, 2005)
Published Print	20 years ago (Aug. 30, 2005)

Funders 0

None

BibTeX

@article{Bartunek_2005, title={Intracoronary Injection of CD133-Positive Enriched Bone Marrow Progenitor Cells Promotes Cardiac Recovery After Recent Myocardial Infarction: Feasibility and Safety}, volume={112}, ISSN={1524-4539}, url={http://dx.doi.org/10.1161/circulationaha.104.522292}, DOI={10.1161/circulationaha.104.522292}, number={9_supplement}, journal={Circulation}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Bartunek, Jozef and Vanderheyden, Marc and Vandekerckhove, Bart and Mansour, Samer and De Bruyne, Bernard and De Bondt, Pieter and Van Haute, Inge and Lootens, Nele and Heyndrickx, Guy and Wijns, William}, year={2005}, month=aug }

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  "abstract": "<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014</jats:italic>\n            </jats:bold>\n            Bone marrow CD133-postive (CD133\n            <jats:sup>+</jats:sup>\n            ) cells possess high hematopoietic and angiogenic capacity. We tested the feasibility, safety, and functional effects of the use of enriched CD133\n            <jats:sup>+</jats:sup>\n            progenitor cells after intracoronary administration in patients with recent myocardial infarction.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014</jats:italic>\n            </jats:bold>\n            Among 35 patients with acute myocardial infarction treated with stenting, 19 underwent intracoronary administration of CD133\n            <jats:sup>+</jats:sup>\n            progenitor cells (12.6\u00b12.2\u00d710\n            <jats:sup>6</jats:sup>\n            cells) 11.6\u00b11.4 days later (group 1) and 16 did not (group 2). At 4 months, left ventricular ejection fraction increased significantly in group 1 (from 45.0\u00b12.6% to 52.1\u00b13.5%,\n            <jats:italic>P</jats:italic>\n            &lt;0.05), but only tended to increase in case-matched group 2 patients (from 44.3\u00b13.1% to 48.6\u00b13.6%,\n            <jats:italic>P</jats:italic>\n            =NS). Likewise, left ventricular regional chordae shortening increased in group 1 (from 11.5\u00b11.0% to 16.1\u00b11.3%,\n            <jats:italic>P</jats:italic>\n            &lt;0.05) but remained unchanged in group 2 patients (from 11.1\u00b11.1% to 12.7\u00b11.3%,\n            <jats:italic>P</jats:italic>\n            =NS). This was paralleled by reduction in the perfusion defect in group 1 (from 28.0\u00b14.1% to 22.5\u00b14.1%,\n            <jats:italic>P</jats:italic>\n            &lt;0.05) and no change in group 2 (from 25.0\u00b13.0% to 22.6\u00b14.1%,\n            <jats:italic>P</jats:italic>\n            =NS). In group 1, two patients developed in-stent reocclusion, 7 developed in-stent restenosis, and 2 developed significant de novo lesion of the infarct-related artery. In group 2, four patients showed in-stent restenosis. In group 1 patients without reocclusion, glucose uptake shown by positron emission tomography with\n            <jats:sup>18</jats:sup>\n            fluorodeoxyglucose in the infarct-related territory increased from 51.2\u00b12.6% to 57.5\u00b13.5% (\n            <jats:italic>P</jats:italic>\n            &lt;0.05). No stem cell-related arrhythmias were noted, either clinically or during programmed stimulation studies at 4 months.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014</jats:italic>\n            </jats:bold>\n            In patients with recent myocardial infarction, intracoronary administration of enriched CD133\n            <jats:sup>+</jats:sup>\n            cells is feasible but was associated with increased incidence of coronary events. Nevertheless, it seems to be associated with improved left ventricular performance paralleled with increased myocardial perfusion and viability.\n          </jats:p>",
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