DOI: 10.1161/atvbaha.111.241471. Intracellular Trafficking and Secretion of VLDL

Intracellular Trafficking and Secretion of VLDL

10.1161/atvbaha.111.241471

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Arteriosclerosis, Thrombosis, and Vascular Biology (276)

Abstract

Steady increase in the incidence of atherosclerosis is becoming a major concern not only in the United States but also in other countries. One of the major risk factors for the development of atherosclerosis is high concentrations of plasma low-density lipoprotein, which are metabolic products of very low-density lipoprotein (VLDL). VLDLs are synthesized and secreted by the liver. In this review, we discuss various stages through which VLDL particles go from their biogenesis to secretion in the circulatory system. Once VLDLs are synthesized in the lumen of the endoplasmic reticulum, they are transported to the Golgi. The transport of nascent VLDLs from the endoplasmic reticulum to Golgi is a complex multistep process, which is mediated by a specialized transport vesicle, the VLDL transport vesicle. The VLDL transport vesicle delivers VLDLs to the cis -Golgi lumen where nascent VLDLs undergo a number of essential modifications. The mature VLDL particles are then transported to the plasma membrane and secreted in the circulatory system. Understanding of molecular mechanisms and identification of factors regulating the complex intracellular VLDL trafficking will provide insight into the pathophysiology of various metabolic disorders associated with abnormal VLDL secretion and identify potential new therapeutic targets.

Bibliography

Tiwari, S., & Siddiqi, S. A. (2012). Intracellular Trafficking and Secretion of VLDL. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(5), 1079â1086.

Authors 2

Samata Tiwari (first)
Shadab A. Siddiqi (additional)

References 98 Referenced 202

10.1161/01.cir.0000035280.64322.31
10.1097/00041433-199410000-00006
10.1194/jlr.M800248-JLR200
10.1074/jbc.R100068200
10.1016/0005-2760(94)90249-6
10.1016/S1050-1738(01)00071-8
10.1074/jbc.M008885200
10.1074/jbc.M107460200
10.1083/jcb.69.2.241
10.1111/j.1365-2796.2005.01556.x
10.1194/jlr.R800090-JLR200
10.1186/1743-7075-7-35
10.1016/j.tem.2011.04.007
10.1016/j.amjmed.2006.01.009
10.1073/pnas.82.14.4597
10.1016/S0021-9258(19)39221-X
10.1126/science.3659919
10.1073/pnas.77.5.2465
10.1152/ajpgi.00123.2007
10.1146/annurev-physiol-021909-135801
10.1073/pnas.86.2.500
10.1016/S0022-2275(20)30267-4
10.1021/bi011757l
10.1038/346382a0
10.1016/0092-8674(92)90202-N
10.1016/S0022-2275(20)39874-6
10.1093/jn/129.2.463S
Shelness GS, Ingram MF, Huang XF, DeLozier JA. Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly. J Nutr. 1999;129:456S–462S. / J Nutr / Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly. by Shelness GS (1999)
10.1194/jlr.R200014-JLR200
10.1074/jbc.273.40.25612
10.1074/jbc.M100294200
10.1002/hep
10.1016/S0021-9258(19)49411-8
10.1016/S0022-2275(20)37125-X
10.1074/jbc.273.42.27225
10.1074/jbc.M100633200
10.1074/jbc.273.38.24649
10.1074/jbc.M705216200
10.1172/JCI6576
10.1016/j.cmet.2008.12.013
10.1016/S0167-4889(98)00047-0
10.1016/S0092-8674(00)81577-9
10.1016/0092-8674(94)90138-4
10.1016/j.febslet.2009.10.038
10.1016/j.cub.2005.11.076
10.1083/jcb.125.1.51
10.1038/365347a0
10.1016/S0021-9258(18)54015-1
10.1074/jbc.C000449200
10.1038/nature01040
10.1083/jcb.200106039
10.1038/34438
10.1083/jcb.152.1.213
10.1006/meth.2000.0954
10.1038/nature04339
10.1073/pnas.191359398
10.1074/jbc.M306898200
10.1042/BJ20071469
10.1242/jcs.00215
10.1097/00041433-200404000-00012
10.1016/j.ymgme.2007.08.120
10.1186/1750-1172-6-1
10.1016/j.jprot.2010.01.010
10.1007/s00125-003-1111-y
10.1161/atvbaha.111.233908
10.1038/372055a0
10.1126/science.1161748
10.1247/csf.21.407
10.1016/S0955-0674(97)80026-9
10.1038/nrm2002
10.1038/362318a0
10.1091/mbc.e07-03-0193
10.1073/pnas.95.26.15781
10.1016/S0092-8674(00)81404-X
10.1016/S0092-8674(00)80191-9
10.1091/mbc.10.2.435
10.1074/jbc.M102786200
10.1091/mbc.e02-09-0556
10.1242/jcs.02803
10.1074/jbc.M601401200
10.1042/BJ20100336
10.1074/jbc.M200249200
10.1016/S0021-9258(19)79016-4
10.1016/j.jprot
10.1073/pnas.87.7.2390
10.1016/S0021-9258(18)37867-0
10.1083/jcb.47.3.745
10.1016/S0022-5320(81)80119-0
10.1016/S0021-9258(18)53730-3
10.1074/jbc.M306920200
10.1016/S0021-9258(18)49269-1
10.1074/jbc.M202015200
10.1016/0014-5793(88)80780-4
10.1074/jbc.M700475200
10.1016/0014-4800(77)90055-7
10.1074/jbc.M610765200
10.1194/jlr.M005611
10.1194/jlr.M002758

Dates

Type	When
Created	13 years, 4 months ago (April 18, 2012, 4:46 p.m.)
Deposited	1 year, 3 months ago (May 12, 2024, 6:54 p.m.)
Indexed	1 day, 12 hours ago (Aug. 31, 2025, 6:36 a.m.)
Issued	13 years, 4 months ago (May 1, 2012)
Published	13 years, 4 months ago (May 1, 2012)
Published Print	13 years, 4 months ago (May 1, 2012)

Funders 0

None

BibTeX

@article{Tiwari_2012, title={Intracellular Trafficking and Secretion of VLDL}, volume={32}, ISSN={1524-4636}, url={http://dx.doi.org/10.1161/atvbaha.111.241471}, DOI={10.1161/atvbaha.111.241471}, number={5}, journal={Arteriosclerosis, Thrombosis, and Vascular Biology}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Tiwari, Samata and Siddiqi, Shadab A.}, year={2012}, month=may, pages={1079–1086} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        31
      ]
    ],
    "date-time": "2025-08-31T10:36:36Z",
    "timestamp": 1756636596470
  },
  "reference-count": 98,
  "publisher": "Ovid Technologies (Wolters Kluwer Health)",
  "issue": "5",
  "content-domain": {
    "domain": [
      "www.ahajournals.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2012,
        5
      ]
    ]
  },
  "abstract": "<jats:p>\n            Steady increase in the incidence of atherosclerosis is becoming a major concern not only in the United States but also in other countries. One of the major risk factors for the development of atherosclerosis is high concentrations of plasma low-density lipoprotein, which are metabolic products of very low-density lipoprotein (VLDL). VLDLs are synthesized and secreted by the liver. In this review, we discuss various stages through which VLDL particles go from their biogenesis to secretion in the circulatory system. Once VLDLs are synthesized in the lumen of the endoplasmic reticulum, they are transported to the Golgi. The transport of nascent VLDLs from the endoplasmic reticulum to Golgi is a complex multistep process, which is mediated by a specialized transport vesicle, the VLDL transport vesicle. The VLDL transport vesicle delivers VLDLs to the\n            <jats:italic>cis</jats:italic>\n            -Golgi lumen where nascent VLDLs undergo a number of essential modifications. The mature VLDL particles are then transported to the plasma membrane and secreted in the circulatory system. Understanding of molecular mechanisms and identification of factors regulating the complex intracellular VLDL trafficking will provide insight into the pathophysiology of various metabolic disorders associated with abnormal VLDL secretion and identify potential new therapeutic targets.\n          </jats:p>",
  "DOI": "10.1161/atvbaha.111.241471",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2012,
        4,
        18
      ]
    ],
    "date-time": "2012-04-18T20:46:16Z",
    "timestamp": 1334781976000
  },
  "page": "1079-1086",
  "update-policy": "http://dx.doi.org/10.1161/crossmarkpolicy",
  "source": "Crossref",
  "is-referenced-by-count": 202,
  "title": "Intracellular Trafficking and Secretion of VLDL",
  "prefix": "10.1161",
  "volume": "32",
  "author": [
    {
      "given": "Samata",
      "family": "Tiwari",
      "sequence": "first",
      "affiliation": [
        {
          "name": "From the Burnett School of Biomedical Sciences (S.T., S.A.S.), College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, FL."
        }
      ]
    },
    {
      "given": "Shadab A.",
      "family": "Siddiqi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "From the Burnett School of Biomedical Sciences (S.T., S.A.S.), College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, FL."
        }
      ]
    }
  ],
  "member": "276",
  "reference": [
    {
      "key": "e_1_3_3_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.cir.0000035280.64322.31"
    },
    {
      "key": "e_1_3_3_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00041433-199410000-00006"
    },
    {
      "key": "e_1_3_3_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1194/jlr.M800248-JLR200"
    },
    {
      "key": "e_1_3_3_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.R100068200"
    },
    {
      "key": "e_1_3_3_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0005-2760(94)90249-6"
    },
    {
      "key": "e_1_3_3_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1050-1738(01)00071-8"
    },
    {
      "key": "e_1_3_3_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M008885200"
    },
    {
      "key": "e_1_3_3_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M107460200"
    },
    {
      "key": "e_1_3_3_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.69.2.241"
    },
    {
      "key": "e_1_3_3_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2796.2005.01556.x"
    },
    {
      "key": "e_1_3_3_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1194/jlr.R800090-JLR200"
    },
    {
      "key": "e_1_3_3_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1186/1743-7075-7-35"
    },
    {
      "key": "e_1_3_3_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.tem.2011.04.007"
    },
    {
      "key": "e_1_3_3_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.amjmed.2006.01.009"
    },
    {
      "key": "e_1_3_3_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.82.14.4597"
    },
    {
      "key": "e_1_3_3_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)39221-X"
    },
    {
      "key": "e_1_3_3_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.3659919"
    },
    {
      "key": "e_1_3_3_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.77.5.2465"
    },
    {
      "key": "e_1_3_3_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpgi.00123.2007"
    },
    {
      "key": "e_1_3_3_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev-physiol-021909-135801"
    },
    {
      "key": "e_1_3_3_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.86.2.500"
    },
    {
      "key": "e_1_3_3_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0022-2275(20)30267-4"
    },
    {
      "key": "e_1_3_3_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi011757l"
    },
    {
      "key": "e_1_3_3_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/346382a0"
    },
    {
      "key": "e_1_3_3_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90202-N"
    },
    {
      "key": "e_1_3_3_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0022-2275(20)39874-6"
    },
    {
      "key": "e_1_3_3_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/jn/129.2.463S"
    },
    {
      "key": "e_1_3_3_29_2",
      "first-page": "456S",
      "article-title": "Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly.",
      "volume": "129",
      "author": "Shelness GS",
      "year": "1999",
      "unstructured": "Shelness GS, Ingram MF, Huang XF, DeLozier JA. Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly. J Nutr. 1999;129:456S\u2013462S.",
      "journal-title": "J Nutr"
    },
    {
      "key": "e_1_3_3_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1194/jlr.R200014-JLR200"
    },
    {
      "key": "e_1_3_3_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.40.25612"
    },
    {
      "key": "e_1_3_3_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M100294200"
    },
    {
      "key": "e_1_3_3_33_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/hep"
    },
    {
      "key": "e_1_3_3_34_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)49411-8"
    },
    {
      "key": "e_1_3_3_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0022-2275(20)37125-X"
    },
    {
      "key": "e_1_3_3_36_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.42.27225"
    },
    {
      "key": "e_1_3_3_37_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M100633200"
    },
    {
      "key": "e_1_3_3_38_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.38.24649"
    },
    {
      "key": "e_1_3_3_39_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M705216200"
    },
    {
      "key": "e_1_3_3_40_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI6576"
    },
    {
      "key": "e_1_3_3_41_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.cmet.2008.12.013"
    },
    {
      "key": "e_1_3_3_42_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0167-4889(98)00047-0"
    },
    {
      "key": "e_1_3_3_43_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81577-9"
    },
    {
      "key": "e_1_3_3_44_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(94)90138-4"
    },
    {
      "key": "e_1_3_3_45_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.febslet.2009.10.038"
    },
    {
      "key": "e_1_3_3_46_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.cub.2005.11.076"
    },
    {
      "key": "e_1_3_3_47_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.125.1.51"
    },
    {
      "key": "e_1_3_3_48_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/365347a0"
    },
    {
      "key": "e_1_3_3_49_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)54015-1"
    },
    {
      "key": "e_1_3_3_50_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.C000449200"
    },
    {
      "key": "e_1_3_3_51_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nature01040"
    },
    {
      "key": "e_1_3_3_52_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200106039"
    },
    {
      "key": "e_1_3_3_53_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/34438"
    },
    {
      "key": "e_1_3_3_54_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.152.1.213"
    },
    {
      "key": "e_1_3_3_55_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/meth.2000.0954"
    },
    {
      "key": "e_1_3_3_56_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nature04339"
    },
    {
      "key": "e_1_3_3_57_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.191359398"
    },
    {
      "key": "e_1_3_3_58_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M306898200"
    },
    {
      "key": "e_1_3_3_59_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/BJ20071469"
    },
    {
      "key": "e_1_3_3_60_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1242/jcs.00215"
    },
    {
      "key": "e_1_3_3_61_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00041433-200404000-00012"
    },
    {
      "key": "e_1_3_3_62_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.ymgme.2007.08.120"
    },
    {
      "key": "e_1_3_3_63_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1186/1750-1172-6-1"
    },
    {
      "key": "e_1_3_3_64_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.jprot.2010.01.010"
    },
    {
      "key": "e_1_3_3_65_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s00125-003-1111-y"
    },
    {
      "key": "e_1_3_3_66_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/atvbaha.111.233908"
    },
    {
      "key": "e_1_3_3_67_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/372055a0"
    },
    {
      "key": "e_1_3_3_68_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1161748"
    },
    {
      "key": "e_1_3_3_69_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1247/csf.21.407"
    },
    {
      "key": "e_1_3_3_70_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0955-0674(97)80026-9"
    },
    {
      "key": "e_1_3_3_71_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nrm2002"
    },
    {
      "key": "e_1_3_3_72_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/362318a0"
    },
    {
      "key": "e_1_3_3_73_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.e07-03-0193"
    },
    {
      "key": "e_1_3_3_74_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.95.26.15781"
    },
    {
      "key": "e_1_3_3_75_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81404-X"
    },
    {
      "key": "e_1_3_3_76_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80191-9"
    },
    {
      "key": "e_1_3_3_77_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.10.2.435"
    },
    {
      "key": "e_1_3_3_78_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M102786200"
    },
    {
      "key": "e_1_3_3_79_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.e02-09-0556"
    },
    {
      "key": "e_1_3_3_80_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1242/jcs.02803"
    },
    {
      "key": "e_1_3_3_81_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M601401200"
    },
    {
      "key": "e_1_3_3_82_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/BJ20100336"
    },
    {
      "key": "e_1_3_3_83_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M200249200"
    },
    {
      "key": "e_1_3_3_84_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)79016-4"
    },
    {
      "key": "e_1_3_3_85_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.jprot"
    },
    {
      "key": "e_1_3_3_86_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.7.2390"
    },
    {
      "key": "e_1_3_3_87_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)37867-0"
    },
    {
      "key": "e_1_3_3_88_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.47.3.745"
    },
    {
      "key": "e_1_3_3_89_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0022-5320(81)80119-0"
    },
    {
      "key": "e_1_3_3_90_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)53730-3"
    },
    {
      "key": "e_1_3_3_91_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M306920200"
    },
    {
      "key": "e_1_3_3_92_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)49269-1"
    },
    {
      "key": "e_1_3_3_93_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M202015200"
    },
    {
      "key": "e_1_3_3_94_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(88)80780-4"
    },
    {
      "key": "e_1_3_3_95_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M700475200"
    },
    {
      "key": "e_1_3_3_96_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-4800(77)90055-7"
    },
    {
      "key": "e_1_3_3_97_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M610765200"
    },
    {
      "key": "e_1_3_3_98_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1194/jlr.M005611"
    },
    {
      "key": "e_1_3_3_99_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1194/jlr.M002758"
    }
  ],
  "container-title": "Arteriosclerosis, Thrombosis, and Vascular Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.111.241471",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        5,
        12
      ]
    ],
    "date-time": "2024-05-12T22:54:07Z",
    "timestamp": 1715554447000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.ahajournals.org/doi/10.1161/ATVBAHA.111.241471"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2012,
        5
      ]
    ]
  },
  "references-count": 98,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          2012,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1161/ATVBAHA.111.241471"
  ],
  "URL": "http://dx.doi.org/10.1161/ATVBAHA.111.241471",
  "relation": {},
  "ISSN": [
    "1079-5642",
    "1524-4636"
  ],
  "subject": [],
  "container-title-short": "ATVB",
  "published": {
    "date-parts": [
      [
        2012,
        5
      ]
    ]
  },
  "assertion": [
    {
      "value": "2011-12-06",
      "order": 0,
      "name": "received",
      "label": "Received",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2012-02-10",
      "order": 1,
      "name": "accepted",
      "label": "Accepted",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2012-05-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}