DOI: 10.1161/01.str.27.11.2086. Hemodynamic Study of the Anterior Communicating Artery

Hemodynamic Study of the Anterior Communicating Artery

10.1161/01.str.27.11.2086

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Stroke (276)

Abstract

Background and PurposeThe anterior communicating artery (ACoA) is a site of predilection for intracranial saccular aneurysms causing subarachnoid hemorrhage. ACoA aneurysms are frequently associated with an asymmetrical circle of Willis. In such cases, the ACoA is probably exposed to high hemodynamic stress caused by a considerable shunt flow across the ACoA to the distal segment of the contralateral anterior cerebral artery (ACA). In the present study, the flow pattern and flow-induced shear stress in the ACoA complex that may initiate aneurysmal lesions were studied under steady and pulsatile flow conditions.MethodsFlow visualization was studied with dye injection and birefringent flow visualization in symmetrical and asymmetrical models of various sizes of ACoA. The distribution of wall shear stress was measured using an electrochemical method based on a diffusion-controlled reaction of ferricyanide ion to ferrocyanide ion at a platinum electrode embedded in the wall of the ACoA model.ResultsWith equal flow rate (Reynolds number 150 to 600), vortical flow was formed in the mouth of the ACoA, and no cross flow through the ACoA was observed. The wall shear stress on the mid-wall of the ACoA was almost zero. However, as soon as the flow rate became unequal, a cross flow through the ACoA was observed. The stagnation point also appeared at the medial junction of the ACoA and ACA. The wall shear stress increased to a very high level at the wall of the ACoA and around the stagnation point.ConclusionsGeometric changes from the symmetrical to the asymmetrical ACoA develop higher shear stress on the ACoA than critical values and the stagnation point at the ACoA junction. A combination of these hemodynamic factors is considered to play an important role in initiation of aneurysm.

Bibliography

Ujiie, H., Liepsch, D. W., Goetz, M., Yamaguchi, R., Yonetani, H., & Takakura, K. (1996). Hemodynamic Study of the Anterior Communicating Artery. Stroke, 27(11), 2086â2094.

Authors 6

H. Ujiie (first)
Dieter W. Liepsch (additional)
Max Goetz (additional)
R. Yamaguchi (additional)
H. Yonetani (additional)
K. Takakura (additional)

References 35 Referenced 85

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Stehbens WE. Aneurysms and anatomical variation of cerebral arteries. Arch Pathol. 1963;75:45-64. / Arch Pathol (1963)
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10.1161/str.15.5.6474536
Hashimoto N, Handa H, Nagata I, Hazama F. Experimentally induced cerebral aneurysms in rats, V: relation of hemodynamics in the circle of Willis to formation of aneurysms. Surg Neurol. 1980;13:41-45. / Surg Neurol (1980)
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10.1113/expphysiol.1975.sp002310
Liepsch DW. Untersuchungen der Strömungsverhältnisse in Verzweigungen von Rohren kleiner Durchmesser bei Stromtrennung. Technical University Munich und VDI Berichte 232: 423-441 1975. Thesis.
Liepsch DW. Strömungsuntersuchungen an Modellen menschlicher Blutgefäß-Systeme. VDI-Fortschrittberichte Reihe 7: Strömungstechnik Nr. 113 1987.
Liepsch DW. Biofluid Mechanics: Blood Flow in Large Arteries. New York NY: Springer Verlag; 1990. (10.1007/978-3-642-52338-0)
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Rhoton AL Jr. Anatomy of saccular aneurysms. Surg Neurol. 1980;14:59-67. Special article. / Surg Neurol (1980)
Lazorthes G, Gouaze A, Santini JJ. Lazorthes Y, Laffonet J. Le modelage du polygone de Willis. Neurochirurgie. 1971;17:361-378. / Neurochirurgie (1971)
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Dates

Type	When
Created	14 years, 2 months ago (June 17, 2011, 4:08 p.m.)
Deposited	5 months, 2 weeks ago (March 6, 2025, 3:30 a.m.)
Indexed	2 months, 1 week ago (June 13, 2025, 12:23 p.m.)
Issued	28 years, 9 months ago (Nov. 1, 1996)
Published	28 years, 9 months ago (Nov. 1, 1996)
Published Print	28 years, 9 months ago (Nov. 1, 1996)

Funders 0

None

BibTeX

@article{Ujiie_1996, title={Hemodynamic Study of the Anterior Communicating Artery}, volume={27}, ISSN={1524-4628}, url={http://dx.doi.org/10.1161/01.str.27.11.2086}, DOI={10.1161/01.str.27.11.2086}, number={11}, journal={Stroke}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Ujiie, H. and Liepsch, Dieter W. and Goetz, Max and Yamaguchi, R. and Yonetani, H. and Takakura, K.}, year={1996}, month=nov, pages={2086–2094} }

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