DOI: 10.1161/01.str.0000144648.89172.0f. Magnitude and Role of Wall Shear Stress on Cerebral Aneurysm

Magnitude and Role of Wall Shear Stress on Cerebral Aneurysm

10.1161/01.str.0000144648.89172.0f

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Stroke (276)

Abstract

Background and Purpose— Wall shear stress (WSS) is one of the main pathogenic factors in the development of saccular cerebral aneurysms. The magnitude and distribution of the WSS in and around human middle cerebral artery (MCA) aneurysms were analyzed using the method of computed fluid dynamics (CFD). Methods— Twenty mathematical models of MCA vessels with aneurysms were created by 3-dimensional computed tomographic angiography. CFD calculations were performed by using our original finite-element solver with the assumption of Newtonian fluid property for blood and the rigid wall property for the vessel and the aneurysm. Results— The maximum WSS in the calculated region tended to occur near the neck of the aneurysm, not in its tip or bleb. The magnitude of the maximum WSS was 14.39±6.21 N/m 2 , which was 4-times higher than the average WSS in the vessel region (3.64±1.25 N/m 2 ). The average WSS of the aneurysm region (1.64±1.16 N/m 2 ) was significantly lower than that of the vessel region ( P <0.05). The WSSs at the tip of ruptured aneurysms were markedly low. Conclusions— These results suggest that in contrast to the pathogenic effect of a high WSS in the initiating phase, a low WSS may facilitate the growing phase and may trigger the rupture of a cerebral aneurysm by causing degenerative changes in the aneurysm wall. The WSS of the aneurysm region may be of some help for the prediction of rupture.

Bibliography

Shojima, M., Oshima, M., Takagi, K., Torii, R., Hayakawa, M., Katada, K., Morita, A., & Kirino, T. (2004). Magnitude and Role of Wall Shear Stress on Cerebral Aneurysm. Stroke, 35(11), 2500â2505.

Authors 8

Masaaki Shojima (first)
Marie Oshima (additional)
Kiyoshi Takagi (additional)
Ryo Torii (additional)
Motoharu Hayakawa (additional)
Kazuhiro Katada (additional)
Akio Morita (additional)
Takaaki Kirino (additional)

References 26 Referenced 652

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10.3171/jns.2003.99.3.0447
10.1056/NEJM199812103392401
Steiger HJ. Pathophysiology of development and rupture of cerebral aneurysms. Acta Neurochir Suppl (Wien). 1990; 48: 1–57. / Acta Neurochir Suppl (Wien) (1990)
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Jou LD, Quick CM, Young WL, Lawton MT, Higashida R, Martin A, Saloner D. Computational approach to quantifying hemodynamic forces in giant cerebral aneurysms. AJNR Am J Neuroradiol. 2003; 24: 1804–1810. / AJNR Am J Neuroradiol (2003)
Katada K Fujii N Banno T Nakane M. Usefulness of isotropic volumetric data in neuroradiological diagnosis. In: Reiser MF Takahashi M Modic M Becker CR eds. Multislice CT 2nd revised ed. Berlin Heidelberg New York: Springer-Verlag; 2004: 45–52. (10.1007/978-3-662-05379-9_5)
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Dates

Type	When
Created	20 years, 9 months ago (Oct. 28, 2004, 4:57 p.m.)
Deposited	1 year, 3 months ago (May 12, 2024, 5:34 p.m.)
Indexed	2 weeks, 4 days ago (Aug. 2, 2025, 11:59 p.m.)
Issued	20 years, 9 months ago (Nov. 1, 2004)
Published	20 years, 9 months ago (Nov. 1, 2004)
Published Print	20 years, 9 months ago (Nov. 1, 2004)

Funders 0

None

BibTeX

@article{Shojima_2004, title={Magnitude and Role of Wall Shear Stress on Cerebral Aneurysm: Computational Fluid Dynamic Study of 20 Middle Cerebral Artery Aneurysms}, volume={35}, ISSN={1524-4628}, url={http://dx.doi.org/10.1161/01.str.0000144648.89172.0f}, DOI={10.1161/01.str.0000144648.89172.0f}, number={11}, journal={Stroke}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Shojima, Masaaki and Oshima, Marie and Takagi, Kiyoshi and Torii, Ryo and Hayakawa, Motoharu and Katada, Kazuhiro and Morita, Akio and Kirino, Takaaki}, year={2004}, month=nov, pages={2500–2505} }

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  "abstract": "<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014</jats:italic>\n            </jats:bold>\n            Wall shear stress (WSS) is one of the main pathogenic factors in the development of saccular cerebral aneurysms. The magnitude and distribution of the WSS in and around human middle cerebral artery (MCA) aneurysms were analyzed using the method of computed fluid dynamics (CFD).\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014</jats:italic>\n            </jats:bold>\n            Twenty mathematical models of MCA vessels with aneurysms were created by 3-dimensional computed tomographic angiography. CFD calculations were performed by using our original finite-element solver with the assumption of Newtonian fluid property for blood and the rigid wall property for the vessel and the aneurysm.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014</jats:italic>\n            </jats:bold>\n            The maximum WSS in the calculated region tended to occur near the neck of the aneurysm, not in its tip or bleb. The magnitude of the maximum WSS was 14.39\u00b16.21 N/m\n            <jats:sup>2</jats:sup>\n            , which was 4-times higher than the average WSS in the vessel region (3.64\u00b11.25 N/m\n            <jats:sup>2</jats:sup>\n            ). The average WSS of the aneurysm region (1.64\u00b11.16 N/m\n            <jats:sup>2</jats:sup>\n            ) was significantly lower than that of the vessel region (\n            <jats:italic>P</jats:italic>\n            &lt;0.05). The WSSs at the tip of ruptured aneurysms were markedly low.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014</jats:italic>\n            </jats:bold>\n            These results suggest that in contrast to the pathogenic effect of a high WSS in the initiating phase, a low WSS may facilitate the growing phase and may trigger the rupture of a cerebral aneurysm by causing degenerative changes in the aneurysm wall. The WSS of the aneurysm region may be of some help for the prediction of rupture.\n          </jats:p>",
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