DOI: 10.1161/01.res.30.6.703. Focal Transient Cerebral Ischemia in the Squirrel Monkey

Focal Transient Cerebral Ischemia in the Squirrel Monkey

10.1161/01.res.30.6.703

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Circulation Research (276)

Abstract

Cerebral adenosine triphosphate and lactate concentrations were measured in the squirrel monkey ( Saimiri sciureus ) before, during, and at selected times after various periods of middle cerebral artery occlusion. The gradual decrease in ATP to 55, 35, and 20%, of normal and the increase in lactate to 7, 8, and 10 times normal after 2, 3, and 4 hours of occlusion, respectively, were reversible with restoration of flow. Electrocorticograms recorded in acute preparations indicated potential for recovery. The correlation of lactate levels with previous determinations of blood flow in this preparation supports the theory that loss of autoregulation and "luxury perfusion" in cerebral ischemia results from localized metabolic acidosis due to accumulation of lactic acid. In a separate group of monkeys, the ischemic lesions were found to be largely reversible after 2 or 3 hours and irreversible after 4 hours of middle cerebral artery occlusion; the cause of death in the monkeys subjected to 4 hours of occlusion was edema, which progressed even after restoration of flow.

Bibliography

SUNDT, T. M., & MICHENFELDER, J. D. (1972). Focal Transient Cerebral Ischemia in the Squirrel Monkey. Circulation Research, 30(6), 703â712.

Authors 2

THORALF M. SUNDT (first)
JOHN D. MICHENFELDER (additional)

References 0 Referenced 52

None

Dates

Type	When
Created	13 years, 2 months ago (June 11, 2012, 8:16 p.m.)
Deposited	1 year, 3 months ago (May 12, 2024, 3:16 p.m.)
Indexed	11 months, 2 weeks ago (Sept. 10, 2024, 7:50 p.m.)
Issued	53 years, 2 months ago (June 1, 1972)
Published	53 years, 2 months ago (June 1, 1972)
Published Print	53 years, 2 months ago (June 1, 1972)

Funders 0

None

BibTeX

@article{SUNDT_1972, title={Focal Transient Cerebral Ischemia in the Squirrel Monkey: EFFECT ON BRAIN ADENOSINE TRIPHOSPHATE AND LACTATE LEVELS WITH ELECTROCORTICOGRAPHIC AND PATHOLOGIC CORRELATION}, volume={30}, ISSN={1524-4571}, url={http://dx.doi.org/10.1161/01.res.30.6.703}, DOI={10.1161/01.res.30.6.703}, number={6}, journal={Circulation Research}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={SUNDT, THORALF M. and MICHENFELDER, JOHN D.}, year={1972}, month=jun, pages={703–712} }

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