DOI: 10.1161/01.res.0000130529.18016.35. Optical Imaging of the Heart

10.1161/01.res.0000130529.18016.35

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Circulation Research (276)

Abstract

Optical techniques have revolutionized the investigation of cardiac cellular physiology and advanced our understanding of basic mechanisms of electrical activity, calcium homeostasis, and metabolism. Although optical methods are widely accepted and have been at the forefront of scientific discoveries, they have been primarily applied at cellular and subcellular levels and considerably less to whole heart organ physiology. Numerous technical difficulties had to be overcome to dynamically map physiological processes in intact hearts by optical methods. Problems of contraction artifacts, cellular heterogeneities, spatial and temporal resolution, limitations of surface images, depth-of-field, and need for large fields of view (ranging from 2×2 mm 2 to 3×3 cm 2 ) have all led to the development of new devices and optical probes to monitor physiological parameters in intact hearts. This review aims to provide a critical overview of current approaches, their contributions to the field of cardiac electrophysiology, and future directions of various optical imaging modalities as applied to cardiac physiology at organ and tissue levels.

Bibliography

Efimov, I. R., Nikolski, V. P., & Salama, G. (2004). Optical Imaging of the Heart. Circulation Research, 95(1), 21â33.

Authors 3

Igor R. Efimov (first)
Vladimir P. Nikolski (additional)
Guy Salama (additional)

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Dates

Type	When
Created	21 years, 1 month ago (July 8, 2004, 4:34 p.m.)
Deposited	1 year, 3 months ago (May 12, 2024, 2:27 p.m.)
Indexed	1 month, 1 week ago (July 26, 2025, 5:24 a.m.)
Issued	21 years, 1 month ago (July 9, 2004)
Published	21 years, 1 month ago (July 9, 2004)
Published Print	21 years, 1 month ago (July 9, 2004)

Funders 0

None

BibTeX

@article{Efimov_2004, title={Optical Imaging of the Heart}, volume={95}, ISSN={1524-4571}, url={http://dx.doi.org/10.1161/01.res.0000130529.18016.35}, DOI={10.1161/01.res.0000130529.18016.35}, number={1}, journal={Circulation Research}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Efimov, Igor R. and Nikolski, Vladimir P. and Salama, Guy}, year={2004}, month=jul, pages={21–33} }

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